complete program

Adaptive and Auto-Immunity 1
Room: Room A (Concord Ballroom) – 5F  (main tower）
Chairs: Yoshihide Asano, Jaehyuk Choi and Kilian Eyerich

13.15 -13.25           ORAL 011  [POSTER 120]
Identification of post-translationally modified trichohyalin epitopes responsible for triggering autoimmunity in alopecia areata
S. D. Jadeja, D. Tobin
Charles Institute of Dermatology, University College Dublin, Dublin, Ireland

13.25-13.35           ORAL 012   [POSTER 074]
Newly identification of a CXCR6⁺ pathogenic skin-resident CD4⁺ T cell subset in a mouse model of allergic dermatitis that requires CXCL16 for its maintenance
R. Asahina, F. Minami, G. Egawa, S. Nakamizo, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

13.35-13.45           ORAL 013    [POSTER 028]
Psychological stress exacerbates IgE-dependent chronic allergic inflammation by suppressing efferocytosis of M2 macrophages
H. Urakami¹, Y. Fujita², K. Nagao², K. Miyake⁴, H. Karasuyama⁴, S. Miyake³, A. Kamiya², S. Yoshikawa³, S. Morizane^1
1Department of Dermatology, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Okayama, Japan, ²Department of Cellular Physiology, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Okayama, Japan, ³Department of Immunology, Juntendo Daigaku Igakubu Daigakuin Igaku Kenkyuka, Bunkyo-ku, Tokyo, Japan, ⁴Inflammation, infection and Immunity Laboratory, Advanced Research Institute, Tokyo Ika Shika Daigaku, Bunkyo-ku, Tokyo, Japan

13.45-13.55           ORAL 014    [POSTER 227]
Immune response and allergenic components of COVID-19 vaccines induced delayed cutaneous reactions
C. Tsai, W. Chung, C. Chen
Drug Hypersensitivity Clinical and Research Center, Department of Dermatology,, Chang Gung Memorial Hospital, Linkou, Taipei, Tucheng and Keelung, Taiwan, Taoyuan, Taiwan

13.55-14.05           ORAL 015    [POSTER 126]
Topical corticosteroids inhibit allergic skin inflammation but are ineffective in impeding the formation and expansion of resident memory T cells
E. Ono¹, V. Lenief¹, M. Lefevre¹, R. Cuzin¹, A. Guironnet-Paquet¹, A. Mosnier¹, A. Nosbaum^{1, 2}, J. Nicolas^{1, 2}, M. Vocanson^1
1Centre International de Recherche en Infectiologie, Lyon, Rhône-Alpes, France, ²Hospices Civils de Lyon, Lyon, Auvergne-Rhône-Alpes , France

14.05-14.15           ORAL 016    [POSTER 001]
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis
H. Terui¹, K. Yamasaki¹, M. Wada-Irimada¹, M. Onodera-Amagai¹, N. Hatchome¹, M. Mizuashi¹, R. Yamashita², T. Kawabe³, N. Ishii³, T. Abe^{4, 5, 6}, Y. Asano¹, S. Aiba^1
1Department of Dermatology, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan, ²Division of Translational Informatics, Kokuritsu Gan Kenkyu Center Sentan Iryo Kaihatsu Center Kashiwa Campus, Kashiwa, Chiba, Japan, ³Department of Microbiology and Immunology, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan, ⁴Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan, ⁵Division of Medical Science, Tohoku Daigaku Daigakuin Ikogaku Kenkyuka, Sendai, Miyagi, Japan, ⁶Department of Clinical Biology and Hormonal Regulation, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan

14.15-14.25          ORAL 017   [POSTER 140]
Comparative scRNA-Seq profiling of four autoimmune skin diseases points to CXCL13 as a potential player in skin autoimmunity
Y. Wang, K. Afshari, M. Frisoli, N. Haddadi, S. Sherman, J. E. Harris, M. Rashighi, M. Garber
University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States

14.25-14.35           ORAL 018    [POSTER 133]
UVB-induced type-I interferon in keratinocytes is associated with expansion of CXCL13+ skin-resident memory T cells in dermatomyositis skin
K. Afshari¹, Y. Wang¹, N. Haddadi¹, S. Sherman¹, J. Richmond¹, R. Vleugels², M. Garber¹, M. Rashighi^1
1University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, ²Harvard Medical School, Boston, Massachusetts, United States

14.35-14.45           ORAL 019   [POSTER 054]
LPCAT1 aggravates hyperproliferation and inflammatory signals in psoriasis
Y. Huang¹, Y. Wang², Y. Wang³, Y. Zhen¹, Q. Sun^1
1Department of Dermatology, Qilu Hospital of Shandong University, Jinan, Shandong, China, ²Department of Dermatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China, ³School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

14.45-14.55           ORAL 020   [POSTER 147]
Sebaceous glands actively contribute to distinct immune response patterns in atopic dermatitis and psoriasis
P. Seiringer^{7, 4, 1}, C. Hillig², T. Biedermann⁷, C. C. Zouboulis⁶, M. Menden², K. Eyerich^{3, 1}, D. Töröcsik^5
1Division of Dermatology and Venerology, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, ²Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, ³Albert-Ludwigs-Universitat Freiburg, Freiburg, Germany, ⁴Zentrum Allergie und Umwelt, Munich, Germany, ⁵Department of Dermatology, Faculty of Medicine, Debreceni Egyetem, Debrecen, Hungary, ⁶Medizinische Hochschule Brandenburg Theodor Fontane, Neuruppin, Germany, ⁷Klinikum rechts der Isar, Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany

14.55-15.05           ORAL 021    [POSTER 076]
TRPM2-dependent autophagy inhibition promotes CXCL16 secretion by keratinocytes under oxidative stress
P. Kang, Y. Wang, J. Chen, S. Li, X. Yi, C. Li
Department of Dermatology, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, China

15.05-15.15           ORAL 022    [POSTER 172]
Spatiotemporal architecting of skin dendritic cell directed immunity and tolerance
Q. Huang¹, A. S. Doane², Y. Liu², J. Valencia⁵, C. Nirschl⁶, J. Hsu², A. Savitz¹, K. Pradhan¹, A. Jaiswal², G. Song-Zhao⁶, M. Bale², R. R. Ricardo-Gonzalez⁴, R. Locksley⁴, T. Lawrence⁷, H. Young⁵, M. Suarez-Farinas³, O. Elemento², N. Anandasabapathy^1
1Department of Dermatology, Weill Cornell Medicine, New York, New York, United States, ²Weill Cornell Medicine, New York, New York, United States, ³Icahn School of Medicine at Mount Sinai, New York, New York, United States, ⁴University of California San Francisco, San Francisco, California, United States, ⁵National Cancer Institute, Bethesda, Maryland, United States, ⁶Harvard Medical School, Boston, Massachusetts, United States, ⁷King’s College London, London, United Kingdom

15.15-15.25           ORAL 023    [POSTER 008]
Characterization and pharmacological inhibition of an adult antibody-transfer mouse model of pemphigus vulgaris
S. Emtenani¹, M. Hofrichter¹, L. Komorowski², C. Probst², S. Patzelt¹, E. Schmidt^{1, 3
1}Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany, ²Institute of Experimental Immunology, EUROIMMUN AG, Lübeck, Germany, ³Department of Dermatology, University of Lübeck, Lübeck, Germany

15.25-15.35           ORAL 024    [POSTER 012]
CD4+ T cells control immune evasive tumors by reprogramming myeloid cells in an IFN-dependent manner
A. Buzzai¹, B. Kruse¹, N. Shridhar¹, A. Braun¹, S. Gellert¹, K. Knauth¹, J. Peters¹, M. Mengoni¹, T. van der Sluis¹, A. Krone¹, D. Yu², S. Höhn¹, Y. Fu¹, M. Essand², R. Geffers³, D. Mougiakakos¹, S. Kahlfuß¹, H. Kashkar⁴, E. Gaffal¹, W. Kastenmüller⁵, A. Müller¹, T. Tüting^1
1Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultat, Magdeburg, Germany, ²Uppsala Universitet, Uppsala, Sweden, ³Helmholtz-Zentrum fur Infektionsforschung GmbH, Braunschweig, Niedersachsen, Germany, ⁴Institute of Molecular Immunology, Köln, Germany, ⁵Institute for Systems Immunology, Würzburg, Germany

15.35-15.45           ORAL 025    [POSTER 154]
Nociceptor sensory neurons promote CD8 T cell response to VACV infection
J. Zhang¹, T. Pan¹, A. Kley¹, J. B. Williams¹, L. Deng², I. Chiu², T. S. Kupper^1
1Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, United States, ²Immunology, Harvard Medical School, Boston, Massachusetts, United States

Artificial Intelligence (AI) and Translational Studies
Room: Room B (Eminence Hall) – 5F (south tower)
Chairs: Takashi Okamoto, Shawn Kwatra, Thomas Tüting

13.15-13.25           ORAL 026    [POSTER 217]
Time-to-event machine learning prediction of metastatic recurrence of localized melanoma
G. Wan^{1, 5}, B. Leung¹, M. DeSimone², N. Nguyen¹, A. Rajeh¹, M. Collier¹, H. Rashdan¹, K. Roster¹, M. Asgari^{1, 5}, A. Gusev³, A. Stagner¹, C. Lian², M. Hurlbert⁴, K. Yu⁵, H. Tsao^{1, 5}, F. Liu⁶, P. Sorger⁵, Y. Semenov^{1, 5
1}Massachusetts General Hospital, Boston, Massachusetts, United States, ²Brigham and Women’s Hospital, Boston, Massachusetts, United States, ³Dana-Farber Cancer Institute, Boston, Massachusetts, United States, ⁴Melanoma Research Alliance, Washington, District of Columbia, United States, ⁵Harvard Medical School, Boston, Massachusetts, United States, ⁶Stevens Institute of Technology, Hoboken, New Jersey, United States

13.25-13.35           ORAL 027    [POSTER 202]
 Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma
S. X. Tan¹, T. Nwe Aung², M. Claeson³, C. Zhou¹, S. Brown¹, B. Acs², D. Lambie⁶, P. Baade⁴, N. Pandeya⁵, H. Soyer¹, B. Smithers⁶, D. Whiteman⁵, D. Rimm², K. Khosrotehrani^1
1The University of Queensland, Saint Lucia, Queensland, Australia, ²Yale University, New Haven, Connecticut, United States, ³Sahlgrenska Academy, Gothenburg, Sweden, ⁴Cancer Council Queensland, Spring Hill, Queensland, Australia, ⁵QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, ⁶Princess Alexandra Hospital, Woolloongabba, Queensland, Australia

13.35-13.45           ORAL 028    [POSTER 203]
Automated skin surface phenotype for melanoma risk assessment
B. D. Betz-Stablein¹, C. Rutjes¹, S. Kahler¹, A. Mothershaw¹, D. Jayasinghe², M. Stark¹, M. Janda², H. Soyer^1
1Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia, ²Centre for Health Services Research, The University of Queensland, Brisbane, Queensland, Australia

13.45-13.55           ORAL 029    [POSTER 212]
Teledermatology photographs deblurring by deep learning models restores the accuracy of blurry images classification
Z. Jiang³, H. Yeh¹, B. Hsu², S. Chou², T. Hsu³, V. S. Tseng², C. Lee^{3, 4
1}Chen Chia-Wei Dermatology, Kaohsiung, Taiwan, ²Computer Science, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ³Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung, Taiwan, ⁴Chang Gung University College of Medicine, Taoyuan, Taiwan

13.55-14.05           ORAL 030    [POSTER 207]
Comparison of neural network classification models to determine patch test reactivity
A. Ravishankar, P. L. Bigliardi
Dermatology, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States

14.05-14.15           ORAL 031    [POSTER 210]
A novel system with an end-to-end framework for mouse scratching detection based on deep learning techniques
J. P. Peng¹, B. Hsu², Y. Lin², V. S. Tseng², C. Lee^3
1Chang Gung Memorial Hospital Kaohsiung Branch Department of Internal Medicine, Kaohsiung, Taiwan, ²National Yang Ming Chiao Tung University Department of Computer Science, Hsinchu, Taiwan, ³Department of Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung, Taiwan

14.15-14.25           ORAL 032    [POSTER 214]
Transforming wound assessment and management with artificial intelligence
P. Bishnoi¹, Y. Ng¹, O. E. Ping², R. Srivastava², T. K. Kyar², D. Y. Tan³, Z. Jingxian³, H. Susainathan³, R. Q. So^2
1Skin Research Institute of Singapore, A*STAR, Singapore, Singapore, ²Institute for Infocomm Research, Singapore, Singapore, ³Diagnostics Development Hub, Singapore, Singapore

14.25-14.35           ORAL 033    [POSTER 1572]
HLA I shields tumor lymphocytes from NK-cell-mediated elimination in the skin
Y. Chang¹, S. Kimeswenger², M. Bobrowicz⁴, S. Pascolo³, W. Hoetzenecker², E. Guenova^1
1Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud, Switzerland, ²Dermatology, Johannes Kepler Universitat Linz, Linz, Austria, ³Dermatology, UniversitatsSpital Zurich, Zurich, Switzerland, ⁴Immunology, Warszawski Uniwersytet Medyczny, Warszawa, Mazowieckie, Poland

14.35-14.45           ORAL 034    [POSTER 1625]
Novel mechanism of cell proliferation in cutaneous T cell lymphoma
X. Zhang, H. Li, C. Chen, J. Hsiang, S. Nam, W. Hu, X. Wu, D. Horne, J. Shively, S. Rosen
City of Hope, Duarte, California, United States

14.45 PM-14.55           ORAL 035    [POSTER 1545]
Circulating tumor DNA reflects tumor burden and detects early recurrence in patients with Merkel cell carcinoma
T. Akaike¹, D. S. Hippe², N. So³, N. Maloney³, L. Gunnell¹, E. Hall¹, A. Rodriguez⁴, A. Aleshin⁴, P. Nghiem¹, L. Zaba^3
1University of Washington, Seattle, Washington, United States, ²Fred Hutchinson Cancer Research Center, Seattle, Washington, United States, ³Stanford University School of Medicine, Stanford, California, United States, ⁴Natera, Inc, Austin, Texas, United States

14.55-15.05           ORAL 036    [POSTER 1556]
CSL324, a G-CSF receptor antagonist, blocks neutrophil migration markers that are upregulated in hidradenitis suppurativa
C. Gamell¹, K. Scalzo-Inguanti¹, B. Sedgmen¹, M. Alhamdoosh¹, C. Millar¹, L. Johnson¹, A. Dyson¹, J. Nicolopoulos², G. Varigos², M. Ng¹, N. Wilson¹, J. Field¹, J. S. Kern², L. M. Lindqvist^1
1CSL Limited, Parkville, Victoria, Australia, ²The Royal Melbourne Hospital, Parkville, Victoria, Australia

15.05-15.15           ORAL 037    [POSTER 1621]
Spatial mass cytometry-based single cell imaging reveals a disrupted epithelial-immune axis in prurigo nodularis
A. Kambala, J. R. Patel, H. Cornman, K. K. Lee, S. V. Reddy, O. O. Oladipo, W. Ho, S. Kwatra
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

15.15-15.25           ORAL 038    [POSTER 1607]
Multiomic analysis of immune-related adverse events (irAEs) in melanoma patients treated with anti-PD1-based immune checkpoint inhibitors (ICIs)
F. Dimitriou¹, P. Cheng¹, A. Saltari¹, R. Staeger¹, A. Tastanova¹, M. Levesque¹, G. Long³, B. Becher², R. Dummer^1
1Dermatology Department, UniversitatsSpital Zurich, Zurich, Switzerland, ²Immunology Department, Universitat Zurich, Zurich, Switzerland, ³Melanoma Institute Australia, North Sydney, New South Wales, Australia

15.25-15.35           ORAL 039    [POSTER 1598 ]
Comparative proteomic analyses of microdissected nevi and melanoma subtypes reveal functional differences
S. Naimy^{2, 3}, D. Kuczek⁴, J. B. Solberg¹, M. Bzorek², T. Litman⁵, A. Mund³, M. B. Lovendorf^{1, 5}, R. Clark⁶, L. R. Gjerdrum^{2, 7}, M. Mann^{3, 4}, B. Dyring-Andersen^{1, 3, 5
1}Department of Dermatology and Allergy, Herlev-Gentofte University Hospital, Hellerup, Denmark, ²Department of Pathology, Copenhagen University Hospital, Zealand University Hospital, Roskilde, Denmark, ³Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark, ⁴Max-Planck-Institute of Biochemistry, Munich, Martinsried, Germany, ⁵Leo Foundation Skin immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, ⁶Department of Dermatology, Brigham’s and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States, ⁷Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

15.35-15.45           ORAL 040    [POSTER 1566 ]
Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor co-stimulatory domains
C. Berry¹, C. Lee¹, A. R. Kelly², S. Oh¹, R. O’Connor², C. Ellebrecht^1
1Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, ²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Carcinogenesis and Cancer Genetics
Room: Room C (Nishiki) – 4F (south tower)
Chairs: Kiarash Khosrotehrani, Kavita Sarin and Remco van Doorn

13.15-13.25          ORAL 041    [POSTER 264 ]
Genetic ablation of host p38δ promotes antitumor immunity and reduces tumor growth
A. Kiss¹, J. Chen¹, F. Cheng¹, C. Wei¹, N. Adusumilli¹, S. Sandhu¹, S. Simmens¹, E. Sotomayor³, T. Efimova^{2, 1
1}The George Washington University, Washington, District of Columbia, United States, ²Northwestern University, Evanston, Illinois, United States, ³Tampa General Hospital, Tampa, Florida, United States

13.25-13.35           ORAL 042    [POSTER 277]
HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses
C. Olivero¹, H. Morgan¹, L. Martuscelli², A. Gibbs¹, B. Shorning¹, C. Borgogna², M. De Andrea², M. Hufbauer³, S. Smola⁴, H. Pfister³, B. Akgul³, M. Gariglio², G. Patel^1
1European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, United Kingdom, ²Translational Medicine, University of Piemonte Orientale, Novara, Italy, ³Virology, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, ⁴Virology, Saarland University Medical Center, Homburg, Germany

13.35-13.45           ORAL 043    [POSTER 297]
Expanded genomic landscape of merkel cell carcinoma identifies new drivers
Y. Zhang¹, Z. Reinstein¹, K. Qiu¹, J. Jackson¹, M. Nichols², H. Liu¹, K. Tsai², J. Choi^1
1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, ²Department of Pathology, Moffitt Cancer Center, Tampa, Florida, United States

13.45-13.55           ORAL 044    [POSTER 267]
Establishment of a new immunocompetent mouse model of merkel cell carcinoma
K. M. Prieto-Sarmiento¹, A. de Mingo Pulido¹, B. R. Sell¹, O. Chavez Chiang¹, P. W. Harms², M. E. Verhaegen², A. Dlugosz², T. Patel³, C. Coarfa³, K. Tsai^1
1Clinical Science, Moffitt Cancer Center, Tampa, Florida, United States, ²Dermatology, University of Michigan, Ann Arbor, Michigan, United States, ³Baylor College of Medicine, Houston, Texas, United States

13.55-14.05           ORAL 045    [POSTER 311]
Single-cell transcriptomics reveals distinct molecular programs in folliculotropic mycosis fungoides
T. Qin¹, A. Billi², J. Runge², R. Wasikowski², Q. Li², Y. Wang³, M. Sartor², P. W. Harms², J. Gudjonsson², A. Hristov², L. C. Tsoi², T. Tejasvi1^2
1Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States, ²University of Michigan, Ann Arbor, Michigan, United States, ³Peking University, Beijing, China

14.05-14.15           ORAL 046    [POSTER 303 ]
Single-cell RNA sequencing of erythrodermic CTCL compared to atopic dermatitis and unspecific chronic erythroderma defines disease-specific markers
K. Rindler¹, S. Chennareddy², M. Medjimorec¹, L. Shaw¹, U. Mann¹, W. Weninger¹, M. Farlik¹, C. Jonak¹, P. Brunner^2
1Department of Dermatology, Medizinische Universitat Wien, Wien, Wien, Austria, ²Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States

14.15-14.25           ORAL 047    [POSTER 253 ]
PRMT1 inhibition as a novel therapeutic approach in squamous cell carcinoma
R. Boudra¹, B. Patenall¹, S. King¹, S. Xu², D. Wang², M. Padilla¹, C. Schmults¹, S. Barthel¹, C. Lian², M. R. Ramsey^1
1Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, United States, ²Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States

14.25-14.35           ORAL 048    [POSTER 244 ]
The sphingosine-1-phosphate-cathelicidin axis has a pivotal role in the development of cutaneous squamous cell carcinoma
K. Park^{1, 2, 3}, Y. Kim^{2, 3}, K. Shin^{1, 4}, Y. Bae¹, Y. Choi¹, A. Nielsen-Scott^{2, 3}, C. Mainzer^{2, 3}, A. Celli^{2, 3}, W. Holleran^{2, 3}, S. Arron^{2, 3}, T. Mauro^{2, 3}, P. Elias^{2, 3}, Y. Uchida^{1, 2, 3
1}Food Science and Nutrition, Hallym University, Chuncheon, Gangwon-do, Korea (the Republic of), ²Dermatology, University of California San Francisco, San Francisco, California, United States, ³Northern California Institute for Research and Education, San Francisco, California, United States, ⁴LaSS Inc., Chunche, Korea (the Republic of)

14.35-14.45           ORAL 049    [POSTER 258 ]
Ire1α nmsc mutations enhance keratinocyte uv response and survival through rac1 activation
S. Mogre, J. Son, A. Glick
The Pennsylvania State University, University Park, Pennsylvania, United States

14.45-14.55           ORAL 050    [POSTER 250 ]
A specific neurotrophin network characterizes cSCC subpopulations and correlates with their behavior by patient-derived spheroids and zebrafish avatar
M. Quadri¹, L. Reggiani Bonetti², R. Panini², N. Tiso³, R. Lotti¹, C. Pincelli¹, A. Marconi¹, E. Palazzo^1
1CHIMOMO, Unimore, Modena, Italy, ²Dept of Pathology, Unimore, Modena, Italy, ³Dept of Biology, UniPD, Padua, Italy

14.5-15.05           ORAL 051    [POSTER 275 ]
Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival
C. Zhou¹, S. X. Tan¹, Y. Kao¹, M. Claeson⁵, S. Brown¹, D. Lambie³, D. Whiteman², H. Soyer¹, M. Stark¹, Q. Nguyen⁴, K. Khosrotehrani^1
1The University of Queensland Frazer Institute, Brisbane, Queensland, Australia, ²QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, ³Pathology Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia, ⁴The University of Queensland Institute for Molecular Bioscience, Saint Lucia, Queensland, Australia, ⁵Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

15.05-15.15           ORAL 052    [POSTER 289 ]
Crosstalk between MET-dependent receptor tyrosine kinase signaling and oncogenic Gαq mutations in melanoma
B. Andreas¹, M. Mengoni¹, S. Seedarala¹, S. Bonifatius¹, E. Kostenis², T. Tüting¹, E. Gaffal^1
1Dermatology, University Hospital Magdeburg, Magdeburg, Germany, ²University of Bonn, Bonn, Germany

15.15-15.25           ORAL 053    [POSTER 233 ]
Epigenetic age dysregulation is associated with clinical features of cutaneous melanoma and melanocytic nevi
R. Jeremian^{1, 2}, J. R. Georgakopoulos^{3, 4}, J. Yeung^{4, 3}, I. Litvinov^{2, 1
1}McGill University Faculty of Medicine and Health Sciences, Montreal, Quebec, Canada, ²McGill University Health Centre, Montreal, Quebec, Canada, ³University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada, ⁴Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

15.25-15.35           ORAL 054    [POSTER 305 ]
Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin
G. J. Fisher¹, W. Xia¹, T. He¹, G. Bou-Gharios², J. J. Voorhees¹, A. Dlugosz¹, T. Quan^1
1Dermatology, University of Michigan, Ann Arbor, Michigan, United States, ²Matrix Biology, University of Liverpool Faculty of Health and Life Sciences, Liverpool, United Kingdom

15.35-15.45           ORAL 055    [POSTER 316 ]
EPHB2 germline mutation in patients with high frequency basal cell carcinomas and prostate carcinoma
A. Chiang¹, G. Swaminathan¹, M. Harris¹, V. Hua¹, W. Chan¹, J. Ramos¹, K. Yekrang¹, H. Do¹, I. Bailey¹, K. E. Rieger^{1, 2}, C. Curtis^{3, 4}, J. Y. Tang¹, A. Oro¹, K. Sarin^1
1Dermatology, Stanford University School of Medicine, Stanford, California, United States, ²Dermatopathology, Stanford University School of Medicine, Stanford, California, United States, ³Medicine (Oncology), Stanford University School of Medicine, Stanford, California, United States, ⁴Genetics, Stanford University School of Medicine, Stanford, California, United States

Clinical Research:  Epidemiology and Observational Research
Room: Room D (Ohgi) 4F (south tower)
Chairs: Chong Hyun Won, Julie Ryan Wolf, Sara Brown

13.15-13.25           ORAL 056    [POSTER 448 ]
A framework to study the epidemiological and molecular basis of psoriasis severity, with application in UK Biobank and BSTOP
J. Saklatvala¹, R. Ramessur¹, M. Simpson¹, S. M. Langan³, S. Brown⁴, L. Paternoster², N. Dand¹, C. Smith^1
1King’s College London, London, United Kingdom, ²University of Bristol, Bristol, United Kingdom, ³London School of Hygiene & Tropical Medicine, London, United Kingdom, ⁴University of Edinburgh, Edinburgh, United Kingdom

13.25-13.35           ORAL 057    [POSTER 446 ]
The risk of lymphoproliferative disorders and skin cancers in patients with psoriasis and inflammatory bowel disease administered biologics
J. Jung, E. Choi, G. Kim, S. Chang, M. Lee, C. Won, W. Lee
Dermatology, Asan Medical Center, Songpa-gu, Seoul, Korea (the Republic of)

13.35-13.45           ORAL 058    [POSTER 407 ]
A population-based cohort study of sodium consumption and psoriasis
A. Chattopadhyay, B. Chiang, Y. Halezeroglu, K. Abuabara
University of California San Francisco, San Francisco, California, United States

13.45-13.55           ORAL 059    [POSTER 394 ]
Differential associations of psoriasis subtypes with autoimmune disorders in United States children and adults: A cross-sectional study
Z. Ren¹, J. Silverberg^2
1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, ²Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States

13.55-14.05           ORAL 060    [POSTER 552 ]
Transitions in blood immune profile in atopic dermatitis from infancy to adulthood
E. Del Duca¹, Y. Renert-Yuval², A. Pavel¹, D. Mikhaylov¹, R. Lefferdink¹, M. Fang¹, A. Sheth³, P. Facheris¹, J. Wu¹, Y. Estrada¹, S. Rangel³, J. Krueger², A. Paller³, E. Guttman-Yassky^1
1Icahn School of Medicine at Mount Sinai, New York, New York, United States, ²Dermatology, The Rockefeller University, New York, New York, United States, ³Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States

14.05-14.15           ORAL 061    [POSTER 383  ]
Non-invasively collected RNA in sebum reflects the characteristics and severity of atopic dermatitis.
A. Tanaka¹, T. Nakahara², K. Masuda³, N. Takada⁴, T. Kuwano⁴, T. Inoue⁴, S. Hoashi⁵, Y. Kawasaki⁵, H. Saeki^6
1Department of Dermatology, Hiroshima Daigaku, Hiroshima, Hiroshima, Japan, ²Department of Dermatology, Kyushu Daigaku, Fukuoka, Fukuoka, Japan, ³Department of Dermatology, Kyoto Furitsu Ika Daigaku, Kyoto, Kyoto, Japan, ⁴Biological Science Laboratory, Kao Kabushiki Kaisha, Chuo, Tokyo, Japan, ⁵Diagnostics Department, Maruho Kabushiki Kaisha, Osaka, Osaka, Japan, ⁶Department of Dermatology, Nihon Ika Daigaku, Bunkyo, Tokyo, Japan

14.15-14.25           ORAL 062    [POSTER 540  ]
A longitudinal cohort study of atopic dermatitis and epigenetic age acceleration across childhood
M. Ye¹, P. Collender², S. M. Langan³, A. Cardenas⁴, K. Abuabara^{1, 2
1}UCSF, San Francisco, California, United States, ²UC Berkeley, Berkeley, California, United States, ³LSHTM, London, United Kingdom, ⁴Stanford University, Stanford, California, United States

14.25-14.35           ORAL 063    [POSTER 558 ]
Higher hemoglobin A1C is associated with greater disease severity in hidradenitis suppurativa
N. Foolad¹, W. Liu^{1, 2}, J. T. Kwock¹, T. Jaleel^1
1Dermatology, Duke University School of Medicine, Durham, North Carolina, United States, ²Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, United States

14.35-14.45           ORAL 064    [POSTER 489 ]
Long-term oral antibiotics for acne and antibiotic treatment failure
K. Bhate¹, R. Mathur², S. M. Langan^1
1London School of Hygiene & Tropical Medicine, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom

14.45-14.55           ORAL 065    [POSTER 470 ]
Regulatory T cells act either by expansion at the acute phase or by steep contraction at the resolution phase in severe drug eruptions
Y. Mizukawa, R. Takahashi, T. Shiohara
Kyorin Daigaku, Mitaka, Tokyo, Japan

14.55-15.05           ORAL 066    [POSTER 562 ]
Merkel polyomavirus antibody testing for detecting recurrent Merkel cell carcinoma: A prospective, real-world outcomes study
L. Gunnell¹, T. Akaike¹, K. Lachance¹, D. S. Hippe², K. Cahill¹, C. Doolittle-Amieva^{2, 1}, L. Zawacki¹, S. Park^{1, 2}, P. Nghiem^{1, 2
1}University of Washington Department of Medicine, Seattle, Washington, United States, ²Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

15.05-15.15           ORAL 067    [POSTER 385 ]
Skin cancers in patients with actinic keratoses
C. Mohr¹, Y. Li¹, L. Navsaria¹, C. Hinkston¹, D. Margolis², M. Wehner^1
1Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States, ²University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States

15.15-15.25           ORAL 068    [POSTER 450 ]
The impact of mental health comorbidities on patient satisfaction: A population study among U.S. adults with skin cancer
C. Read^{2, 1, 3}, J. F. Apperley², S. P. Hettiaratchy², A. Armstrong^1
1Dermatology, University of Southern California, Los Angeles, California, United States, ²Medicine, Imperial College London, London, United Kingdom, ³Dermatology, University of Washington, Seattle, Washington, United States

15.25-15.35           ORAL 069    [POSTER 541 ]
Gene set enrichment analysis identifies biological networks associated with skin aging in a large Japanese population: Data from the Nagahama cohort
J. Latreille³, G. Thorn^{1, 2}, R. Jdid³, G. Gendronneau³, Y. Tabara⁴, Y. Harada⁵, S. Forestier³, C. Chelala^{1, 2}, F. Matsuda^4
1Bioinformatics Unit, Barts Cancer Institute, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom, ³IRD, Chanel SAS, PANTIN, Île-de-France, France, ⁴Center for Genomic Medicine, Kyoto Daigaku Igaku Kenkyuka Fuzoku Genome Igaku Center, Kyoto, Japan, ⁵Research and Technology Development Laboratory, Chanel Kabushiki Kaisha Funabashi Corporate Operations Center, Funabashi, Chiba, Japan

15.35-15.45           ORAL 070    [POSTER 421 ]
Genotype-phenotype correlation analysis in Japanese patients with pachydermoperiostosis
R. Tanaka¹, H. Niizeki¹, T. Nomura², A. Seki³, S. Narumi⁴, K. Nakabayashi⁵, K. Yoshida^1
1Dermatology, National Center for Child Health and Development, Tokyo, Japan, ²Dermatology, Kyoto University, Kyoto, Japan, ³Orthopaedic Surgery, National Center for Child Health and Development, Tokyo, Japan, ⁴Molecular Endocrinology, National Center for Child Health and Development, Tokyo, Setagaya-ku, Japan, ⁵Maternal-Fetal Biology, National Center for Child Health and Development, Tokyo, Japan

Genetic Diseases
Room: Room E (Moonlight) – 43F (main tower)
Chairs: Akiharu Kubo, Cristina de Guzman Strong, Edel O’Toole

13.15-13.25           ORAL 071    [POSTER 806 ]
Results from VIITAL: A phase 3, randomized, intrapatient-controlled trial of an investigational collagen type VII gene–corrected autologous cell therapy, EB-101, for the treatment of recessive dystrophic epidermolysis bullosa (RDEB)
J. Y. Tang², M. P. Marinkovich^{2, 3}, K. Wiss⁴, D. McCarthy⁵, A. Truesdale¹, A. S. Chiou², J. K. McIntyre⁴, A. Moore¹, I. Grachev^1
1Abeona Therapeutics Inc, Cleveland, Ohio, United States, ²Stanford University School of Medicine, Stanford, California, United States, ³VA Palo Alto Health Care System, Palo Alto, California, United States, ⁴University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, ⁵Abeona Therapeutics Inc, Cleveland, Ohio, United States

13.25-13.35           ORAL 072    [POSTER 853 ]
HMCN1 variants aggravate epidermolysis bullosa phenotype
S. Bergson^{1, 2}, O. Sarig¹, A. Nitzan², S. Hainzl³, T. Kocher³, M. Giladi^{1, 2}, J. Illmer³, J. Mohamad^{1, 2}, E. Geller^{1, 2}, K. Malovitski^{1, 2}, Y. Feller^{1, 2}, N. Eretz Kdosha¹, R. Zauner³, J. Pinon Hofbauer³, R. Shalom-Feuerstein⁴, V. Wally³, U. Koller³, R. Zaidel-Bar², L. Samuelov^{1, 2}, E. Sprecher^{1, 2
1}Tel Aviv Medical Center, Tel Aviv, Israel, ²Tel Aviv University, Tel Aviv, Israel, ³Paracelsus Medical University, EB House Austria, Salzburg, Austria, ⁴Technion Israel Institute of Technology, Haifa, Israel

13.35 PM-13.45          ORAL 073    [POSTER 849 ]
Twin prime editing for restoring type VII collagen expression in primary recessive dystrophic epidermolysis patient cells
M. Osborn, B. Steinbeck, A. N. McElroy, J. Tolar
Pediatrics, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States

13.45-13.55           ORAL 074    [POSTER 884 ]
Reproducible correction of COL7A1 nonsense variants with ABE8e adenine base editor
J. K. Jackow¹, A. Sheriff¹, I. Guri¹, I. Brooks¹, M. Dimitrievska¹, G. Newby², D. Liu², L. Laczmanski³, J. A. McGrath^1
1St John’s Institute of Dermatology, King’s College London, London, United Kingdom, ²Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States, ³Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

13.55-14.05           ORAL 075    [POSTER 875 ]
ELX-02 suppress premature stop mutations and restores type VII collagen and laminin 332 function in RDEB and JEB
Y. Hou¹, X. Tang¹, L. Bainvoll¹, S. Aghamohammadzadeh², M. Chen^1
1Dermatology, University of Southern California, Los Angeles, California, United States, ²Eloxx Pharmaceuticals, Watertown, Massachusetts, United States

14.05-14.15           ORAL 076    [POSTER 861 ]
CTSZ pathogenic variants affect EGFR expression and cause autosomal dominant palmoplantar keratoderma
K. Malovitski^{1, 2}, O. Sarig¹, Y. Feller^{1, 2}, S. Bergson^{1, 2}, S. Assaf^{1, 2}, J. Mohamad^{1, 2}, M. Pavlovsky¹, M. Giladi^{2, 3}, E. Sprecher^{1, 2
1}Division of Dermatology, Tel Aviv Medical Center, Tel Aviv, Israel, ²Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel, ³Department of Internal Medicine D, Tel Aviv Medical Center, Tel Aviv, Israel

14.15-14.25           ORAL 077    [POSTER 807 ]
Alternative mRNA splicing regulates epidermal differentiation
S. Takashima^{1, 3}, W. Sun², A. Otten¹, P. Cai², J. Bui¹, M. Mai¹, O. Amarbayar¹, B. Cheng¹, E. Tong¹, Z. Li², K. Qu², B. Sun^1
1Department of Dermatology, University of California San Diego, La Jolla, California, United States, ²Division of Molecular Medicine, University of Science and Technology of China, Hefei, Anhui, China, ³Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

14.25-14.35           ORAL 078    [POSTER 812  ]
Regulation of keratinocyte proliferation and differentiation by nucleoporins through nucleocytoplasmic trafficking and direct chromatin binding
X. Bao, A. Neely, Y. Zhang, H. Zhang
Northwestern University, Evanston, Illinois, United States

14.35 PM-14.45           ORAL 079    [POSTER 864  ]
Homologous recombination is prevalent in normal keratinocytes in vivo in mice
G. Egawa, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

14.45-14.55           ORAL 080    [POSTER 840 ]
Excess klhl24 impairs skin wound healing by degradation of vimentin
Y. Liu¹, J. Cui², J. Zhang², Z. Chen¹, Z. Song¹, D. Bao¹, R. Xiang¹, D. Li¹, Y. Yang^1
1Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China, ²Peking University First Hospital, Beijing, China

14.55-15.05           ORAL 081    [POSTER 860 ]
Fragile WWOX gene maintains genome integrity in fibroblasts
H. Cheng², Y. Chou³, C. Hsu², L. Hsu^1
1Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University College of Medicine, Tainan, Taiwan, ²Department of Dermatology, National Cheng Kung University College of Medicine, Tainan, Taiwan, ³Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan

15.05-15.15           ORAL 082    [POSTER 882 ]
Enhancer RNA (eRNA) profiling to understand transcription regulation in keratinocytes
M. T. Patrick, M. Sarkar, Z. Zhang, H. Zhang, J. T. Elder, J. Gudjonsson, L. C. Tsoi
University of Michigan, Ann Arbor, Michigan, United States

15.15-15.25           ORAL 083    [POSTER 877 ]
Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes
M. Lee^{1, 2}, M. Ben Hammouda¹, W. Miao¹, Y. J. Jin¹, Y. Huang¹, H. Sun¹, V. Markovtsov³, J. Y. Zhang^1
1Dermatology, Duke University School of Medicine, Durham, North Carolina, United States, ²Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States, ³Rigel Pharmaceuticals Inc, South San Francisco, California, United States

15.25-15.35           ORAL 084    [POSTER 808 ]
Seizures in Sturge-Weber syndrome are associated with disrupted calcium metabolism
D. Zecchin^{1, 2}, N. Knoepfel^{1, 2, 3}, A. K. Gluck⁴, M. Stevenson⁴, H. Richardson³, S. Polubothu^{2, 3}, A. Inoue⁵, K. Lines⁴, A. Chesover³, T. Jacques^{3, 2}, F. Hannan⁴, U. Loebel³, R. Semple⁶, R. V. Thakker⁴, V. A. Kinsler^{1, 2, 3
1}The Francis Crick Institute, London, London, United Kingdom, ²University College London, London, London, United Kingdom, ³Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom, ⁴University of Oxford, Oxford, Oxfordshire, United Kingdom, ⁵Tohoku Daigaku, Sendai, Miyagi, Japan, ⁶University of Edinburgh, Edinburgh, United Kingdom

15.35-15.45           ORAL 085    [POSTER 841 ]
A vitiligo-associated SNP (rs706779) controls IL15RA isoforms and T cell activation in epidermal keratinocytes
K. Okamura^{1, 2}, S. Shan³, Q. Tang^{1, 4}, P. Vangala³, X. Fan¹, C. Salomão Lopes³, Y. Cao³, W. Ko³, T. Suzuki², A. Khvorova⁴, M. Garber³, J. E. Harris^1
1Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, ²Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan, ³Department of Bioinformatics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, ⁴RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States

Tissue Regeneration and Wound Healing
Room: Room F (Harmony) – 44F (main tower)
Chairs: Sung-Jan Lin, Xiaomin Bao, Kaisa Tasanen

13.15-13.25           ORAL 086    [POSTER 1512 ]
Combined transcriptome and epigenome profiling reveal regulators of dermal fibroblast state switch
T. Kirk, A. Ahmed, J. Connelly, E. Rognoni
Queen Mary University of London, London, United Kingdom

13.25-13.35           ORAL 087    [POSTER 1448 ]
Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration
A. S. Oak, Y. Zheng, A. Nace, R. Yang, A. Ray, G. Cotsarelis
Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States

13.35-13.45           ORAL 088    [POSTER 1478 ]
TEM1/endosialin/CD248 promotes pathologic scarring by augmenting TGF-β activity through its receptor stability in dermal fibroblasts
Y. Hong^{1, 2, 4}, Y. Lin^{1, 2}, Y. Chang¹, Y. Huang¹, J. A. McGrath^{1, 6}, H. Wu^{2, 3, 4}, C. Hsu^{1, 2, 5
1}Department of Dermatology, National Cheng Kung University, Tainan, Taiwan, ²International Center for Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan, ³Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan, ⁴The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, ⁵Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, ⁶St John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, London, United Kingdom

13.45-13.55           ORAL 089    [POSTER 1475 ]
Single cell RNA-seq reveals cell-type specific circadian regulations in the mouse dermis
J. Duan¹, M. Ngo¹, S. Karri², J. Lowengrub¹, B. Shahbaba¹, B. Andersen^2
1Center for Complex Biological Systems, University of California Irvine, Irvine, California, United States, ²Department of Biological Chemistry, University of California Irvine, Irvine, California, United States

13.55-14.05           ORAL 090   [POSTER 1480  ]
CXCR4 expression by regulatory T cells promotes cutaneous tissue regeneration
J. Cohen, M. Rosenblum
Dermatology, University of California San Francisco, San Francisco, California, United States

14.05-14.15          ORAL 091   [POSTER 1518 ]
Identification of gene products from staphylococcus aureus that inhibit keratinocyte migration and wound repair
M. D. Bagood¹, A. Horswill², R. L. Gallo^1
1Dermatology, University of California San Diego, La Jolla, California, United States, ²Immunology & Microbiology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States

14.15-14.25          ORAL 092   [POSTER 1493 ]
Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway
D. C. Wan, M. Griffin, C. E. Berry, M. T. Longaker
Surgery, Stanford University School of Medicine, Stanford, California, United States

14.25-14.35          ORAL 093   [POSTER 1520 ]
Tissue mechanics driven symmetry breaking and cellular reprogramming during regenerative wound healing
H. Harn¹, C. Huang^{1, 2, 3}, C. Chen^{1, 4}, A. Sarkar⁵, B. Van Handel⁵, T. E. Woolley⁶, D. Evseenko⁵, C. Chuong^1
1Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States, ²Ostraw School of Dentistry, University of Southern California, Los Angeles, California, United States, ³Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ⁴The IEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, ⁵Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States, ⁶Cardiff University School of Mathematics, Cardiff, United Kingdom

14.35-14.45          ORAL 094   [POSTER 1541 ]
Co-transcription factors YAP and TAZ regulate dermal extracellular matrix homeostasis and scar formation in mouse skin
A. Ermilov, Z. Qin, A. Kim, T. Quan, J. J. Voorhees, G. J. Fisher
Dermatology, University of Michigan, Ann Arbor, Michigan, United States

14.45-14.55          ORAL 095   [POSTER 1453 ]
LncRNA SNHG26 facilitates inflammatory to proliferative state transition of keratinocyte progenitors during wound healing
D. Li^{1, 2}, Z. Liu², L. Zhang², X. Bian², J. Wu³, L. Li¹, L. Pan¹, Y. Xiao¹, J. Wang¹, X. Zhang¹, W. Wang⁴, M. Toma², M. Piipponen², L. Luo², P. Sommar², N. Xu Landén^2
1Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China, ²Karolinska Institutet, Stockholm, Stockholm, Sweden, ³Wenzhou Medical University, Wenzhou, Zhejiang, China, ⁴East China Normal University, Shanghai, Shanghai, China

14.55-15.05          ORAL 096   [POSTER 1506 ]
Multimodal transcriptomics highlight fibroblast heterogeneity and pathological signaling networks in keloid
Y. Liu^{1, 2}, C. F. Guerrero-Juarez², Q. Nie², J. Li¹, M. Plikus^2
1Xiangya Hospital Central South University, Changsha, Hunan, China, ²University of California Irvine School of Biological Sciences, Irvine, California, United States

15.05-15.15          ORAL 097   [POSTER 1519 ]
Topical type VII collagen increased elastic fiber formation, accelerated wound closure and reduced scarring of diabetic pigskin wounds.
D. Woodley, Y. Hou, X. Tang, C. Tan, K. Zhang, L. Bainvoll, W. Li, M. Chen
Dermatology, University of Southern California, Los Angeles, California, United States

15.15-15.25          ORAL 098   [POSTER 1500 ]
FoxO3a-regulating mitochondrial dynamics affects wound healing through regulating fibroblast migration
S. Goto¹, M. Moriyama², M. Wakatake³, Y. Miyake¹, H. Moriyama^1
1Kinki Daigaku, Higashiosaka, Osaka, Japan, ²Kinki Daigaku, Higashiosaka, Osaka, Japan, ³Kinki Daigaku, Higashiosaka, Osaka, Japan

15.25-15.35          ORAL 099   [POSTER 1507  ]
MCSP⁺ pericytes on the dermal capillary loop as a potential source for epidermal stem/ progenitor cells and their reduction with age.
M. Sawane, T. Tsutsui, M. Komata, R. Kami, H. Aoki, K. Kajiya
MIRAI Technology Institute, Shiseido Co., Ltd, Yokohama, Japan

15.35-15.45          ORAL 100   [POSTER 1455 ]
Identification and characterization of specific subsets in systemic sclerosis fibroblast cultures
A. S. Rosendahl¹, K. Schönborn¹, N. Kleinenkuhnen², T. Baar², A. Tresch², B. Eckes¹, P. Moinzadeh³, T. Krieg^1
1Translational Matrix Bioogy, Faculty of Medicine, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, ²Institute of Medical Statistics and Computational Biology, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, ³Department of Dermatology, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany

Deciphering pathways in the syndromic keratodermas: insights into oesophageal cancer
David Kelsell

Room: Room A (Concord Ballroom) – 5F  (main tower）
Chair: Sabine Eming

Symposium for Platinium Sponsor

Sanofi Symposium
Title:  Skin Barrier, Neuroimmune Axis, and Type 2 Inflammation in Atopic Dermatitis: Research breakthroughs leading to therapeutic innovations for patients with atopic dermatitis
Room: Room B (Eminence Hall) – 5F (south tower)

PROGRAM: 

Chair: Masayuki Amagai

Role of Type 2 Inflammation in Chronic Inflammatory Diseases
Constance Katelaris

Importance of Skin Barrier Dysfunction in Driving AD Pathophysiology
Lisa A. Beck

Connection Between Type 2 Inflammation and the Neuroimmune Mechanisms and Pruritus in AD
Tilo Biedermann

ePoster Stage 1: Adaptive and Auto-Immunity I & II
Chairs: Hayato Takahashi, Sam Hwang, Manuela Pigors 

ePoster Stage 2: Carcinogenesis and Cancer Genetics/Photobiology & Skin of Color
Chairs: Jong Hee Lee, Snehlata Kumari, Nabiha Yusuf and Beate Lichtenberger

ePoster Stage 3: Clinical Research – Epidemiology and Observational Research I & II 
Chairs: Young Lee, Helmut Schaider, Howa Yeung, and Marie-Charlotte Brüggen

ePoster Stage 4: Genetic Disease, Gene Regulation, and Gene Therapy
Chairs: Rei Watanabe, Rui Yi, Fernando Larcher

ePoster Stage 5: Tissue Regeneration and Wound Healing/Skin, Appendages, and Stem Cell Biology 
Chairs: Doyoung Kim, Bethany Perez White, Hisham Bazzi

ePoster discussions will take place in the Poster Hall space (NS Building) on our five ePoster stages.

ePoster Stage 1: Adaptive and Auto-Immunity I & II
Chairs: Hayato Takahashi, Sam Hwang, Manuela Pigors 

037 The intra-niche activation of clonal CXCL13+CD4+ T cells in tertiary lymphoid structures associated with non-healing blisters of pemphigus
A. Lee

064 CD301b+ dermal dendritic cells drive activation of cytotoxic T lymphocytes in a murine contact dermatitis
F. Minami

003 Memory B cells of atopic individuals preferentially express IL-31RA: a putative role of IL-31 in B cell biology
Z. Unger

070 Impact of autoantibodies on atopic dermatitis
T. Hisamoto

121 Pharmacological inhibition of the neonatal Fc receptor reduces disease activity in an antibody transfer-induced model of bullous pemphigoid
M. Pigors

168 TLR7-VGLL3 synergism potentiates lupus-like autoimmunity in mice
O. Plazyo

056 IKZF1 and IKAROS overexpression contributes to the pathogenesis of alopecia areata
Y. Arakawa

039 Inhibitory effect on skin fibrosis by regulating Th17 and regulatory T cell imbalance in a systemic sclerosis mouse model and the involvement of alteration in the intestinal microbiota
A. Sekiguchi

014 Sex as a variable in the composition of skin residing T cells
H. Koguchi-Yoshioka

073 Arteriosclerosis derived from cutaneous inflammation is ameliorated by the deletion of IL-17A or IL-17F
T. Nakanishi

166 Granzyme K stimulates a novel pathway of complement activation
E. Theisen

079 Generation and characterization of the Psmb8 G201V mutation knock-in mice as a model for Nakajo-Nishimura syndrome
T. Hara

016 Immune competent skin organoids reveal monkeypox dynamics
A. J. Pavlovitch-Bedzyk

053 Conformational epitope mapping of autoantibodies against BP180 in dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid
S. Mai

075 Cellular subsets and signaling pathways of IgA vasculitis revealed by single-cell RNA sequencing
D. Tie

160 Local precursors are capable of replenishing tissue-resident memory T cells in healthy and diseased skin
E. Hoffer

002 Gene flow from archaic hominins causes psoriasis, ankylosing spondylitis, and Behçet’s disease
A. Arakawa

ePoster discussions will take place in the Poster Hall space (NS Building) on our five ePoster stages.

ePoster Stage 2: Clinical Research – Epidemiology and Observational Research I & II 
Chairs: Young Lee, Helmut Schaider, Howa Yeung, and Marie-Charlotte Brüggen

563 Increased incidence of cutaneous melanoma and merkel cell carcinoma in subgroups of patients with primary cutaneous B-cell lymphoma: A SEER database analysis
L. Banner

411 Associations between immune-related diseases and skin cancer: An analysis of the diverse All of US research program
E. M. Lin

475 Skin of color and mucocutaneous ulcers are associated with increased disease severity in anti-NXP2 dermatomyositis patients
C. Bax

485 Sleep disturbance impacts physical and psychosocial health of children with atopic dermatitis
C. Mann

461 Total serum IgE levels as a predictor for clinical response to omalizumab in patients with chronic spontaneous urticaria: A systematic review and meta-analysis
H. C. Chang

408 Disaggregated analysis of Asian ethnicities reveals disparities in melanoma treatment timeliness
L. S. Fane

561 Can systemic levels of BNP predict itch severity?
L. A. Nattkemper

442 The influence of psoriasis on clinical outcomes following burn Injury
D. Thomas

419 Comparison of topical fluorouracil and cryotherapy in Medicare patients with actinic keratoses: A retrospective cohort study
M. K. Nowakowska

565 Assessing postoperative complication risk in patients with pre-existing diabetes mellitus who undergo mohs micrographic surgery
D. Garate

473 Clinical characteristics and risk of second malignancies of extramammary paget’s disease patients in Canada and Japan
F. Al Ghazawi

463 Comorbid conditions associated with alopecia areata: A systematic review and update
S. Ly.

513 Zinc dyshomeostasis in patients with bullous pemphigoid and BP180-deficient mice
C. Chu

426 Association of stratum corneum and breast milk factors with the development of atopic dermatitis in infancy: A prospective birth cohort study
R. Fukuda

468 Use of calcitonin gene-related peptide monoclonal antibodies in patients with rosacea: An exploratory, comparative case series
T. Sia

392 Hair loss after drug reaction with eosinophilia and systemic symptoms: A multicentric retrospective study
J. Lee

452 Validation of LRINEC score and establishment of novel score in Japanese patients with necrotizing fasciitis
Y. Norimatsu

ePoster discussions  will take place in the Poster Hall space (NS Building) on our five ePoster stages.

ePoster Stage 3: Tissue Regeneration and Wound Healing/Skin, Appendages, and Stem Cell Biology 
Chairs: Doyoung Kim, Bethany Perez White, Hisham Bazzi

1458 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis
A. Ahmed

1446 RNase L acts as a regeneration suppressor
C. Kirby

1516 Genetic mouse models and a new pro-lymphangiogenic treatment approach reveal beneficial effects of lymphatic vessel activation in cutaneous wound healing
M. Detmar

1473 Hippo pathway drives excessive fibrosis in hidradenitis suppurativa
K. R. van Straalen

1479 The cutaneous ischemia-reperfusion injury-induced pressure ulcer was attenuated in amyotrophic lateral sclerosis mice model via decreased nerve neurons and neuro peptides resulting in suppressing oxidative stress.
A. Uchiyama

1539 A paradigm shift: Inflammatory response in chronic wounds halts progression of healing
M. Tomic-Canic

1468 Lymphatic dysfunction affects both collagen degradation and collagen synthesis, leading to a paradoxical reduction in dermal fibrosis
M. Sugaya

1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling
S. Sim

1482 Physical stress reveals stem cell resources in nail
H. Kosumi

1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth
G. Chen

1349 Inducing fate changes at the hair follicle stem cell nice
C. Clavel

1391 Cell death functions in hair follicle regeneration
G. Mantellato

1428 DKK2 and SOSTDC1 cooperate to initiate the first catagen phase of the hair follicle growth cycle
A. Ho

1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function.
S. Iriyama

1378 A multi-omics approach to identifying factors involved in hair follicle growth and development
N. Pantelireis

1346 Functional roles of Krox20 (Egr2) in Epithelial Stem Cells
E. Ghotbi

1413 From force to fate: LINCing cell junctions to nuclear morphology
A. Banerjee

ePoster discussions will take place in the Poster Hall space (NS Building) on our five ePoster stages.

ePoster Stage 4: Carcinogenesis and Cancer Genetics/Photobiology & Skin of Color 
Chairs: Jong Hee Lee, Snehlata Kumari, Nabiha Yusuf and Beate Lichtenberger

291 Dysregulation of N6-methyladenine DNA methylation as a new epigenetic mechanism in skin tumorigenesis
Y. He

271 The invasive niche confers resistance to therapy in basal cell carcinoma
F. Kuonen

308 Immuno cancer-associated fibroblasts are a major source of cytokines in malignant skin cancer
B. Aschenbrenner

256 Non-canonical control of hedgehog signaling in skin basal cell carcinoma
R. Iglesias-Bartolome

232 Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy
H. Wong

236 Visualizing somatic alterations in spatial transcriptomics data of skin cancer
H. Shain

235 Distinct biological pathways associated with individual stages of tumor progression in KIT-altered melanoma
E. Everdell

293 Acidosis promotes immune escape through the IFN-γ-induced induction of PD-L1 transcription in cancer cells
D. Stowbur

274 Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype
J. Thomson

1178 Mechanisms of type I interferon-mediated UVB sensitivity in human keratinocytes
N. Haddadi

1170 Investigating the molecular mechanisms of solar urticaria
M. Peake

1175 Impact of low dose UVA radiation on UVB radiation-induced DNA damage and skin carcinogenesis
K. M. Rolfes,

1142 The IL-1α stimulated expression of the wrinkle-inducing elastase neprilysin in adult human dermal fibroblasts is mediated via an intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1
U. C. Pinnawala

1165 PDT-resistant skin tumor cells secrete CCL2 to induce TAMs recruitment and suppressive tumor microenvironment.
Y. Fu

1310 Characterization of differences in epidermal lipid composition between psoriatic skin of color and white psoriatic skin
R. Haughton

1317 S6K2 is a vulnerability in MAPK-driven acral melanoma
R. Brathwaite

1292 Molecular phenotyping of keloid skin samples suggests polar immune dysregulation
J. Bar

1314 The JAK/STAT signaling pathway: Considerations in the management of hidradenitis suppurativa in skin of color
C. A. Okeke

ePoster discussions will take place in the Poster Hall space (NS Building) on our five ePoster stages.

ePoster Stage 5: Genetic Disease, Gene Regulation, and Gene Therapy
Chairs: Rei Watanabe, Rui Yi, Fernando Larcher

818 Multi-condition TWAS for inflammatory skin disorders highlights roles of genetic signals in cytokine-stimulated keratinocytes
H. Zhang

862 Hedgehog signaling and ENPP1 role in epidermal proliferation and melanin synthesis
M. Pavlovsky

903 Utilizing an organoid-based approach for the derivation of genetically corrected keratinocytes and fibroblasts in an induced pluripotent stem cell therapy for skin diseases
M. Pavlova

878 CRISPR/Cas9 targeting an intronic region retrieving protein expression in a compound heterozygous model mice via inducing revertant mosaicism pathways
H. Nguyen

803 Editing a missense to a nonsense keratin 9 gene mutation restores intermediate filament integrity
T. Trafoier

899 Phenotypic and genomic characterization of eight patients with patterned cutaneous hypopigmentation associated with extracutaneous findings
Z. Cai

825 Basement membrane proteins in NF1-associated neurofibroma extracellular matrix characterize tumor development and treatment response to MEK inhibitor
L. Q. Le

To encourage delegates to communicate with each other actively and provide the opportunity for networking while indulging in Japanese culture, Japanese traditional festival style called “En-nichi” will be arranged. Delegates can enjoy rows of stalls of local Japanese food. At the end of the gathering, delegates will be cordially invited to join the circle of “Bon-Odori” (bon dancing).

Date: Thursday 11 May 2023
Venue: Keio Plaza Hotel
Rooms: Room A (Concord Ballroom) and Room B (Eminence Hall)

Entrance fees: $35
BOOK YOUR SEAT HERE

From 10 May – Onsite, please visit the ISID 2023 Meeting Registration
Counter in the Room HANA C/D for ticket availability.