ePoster discussions will take place in the Poster Hall space (NS Building) on our five ePoster stages.

ePoster Discussion Session 1 - Thursday 11 May - 18.10-19.40

037 The intra-niche activation of clonal CXCL13+CD4+ T cells in tertiary lymphoid structures associated with non-healing blisters of pemphigus
A. Lee

064 CD301b+ dermal dendritic cells drive activation of cytotoxic T lymphocytes in a murine contact dermatitis
F. Minami

003 Memory B cells of atopic individuals preferentially express IL-31RA: a putative role of IL-31 in B cell biology
Z. Unger

070 Impact of autoantibodies on atopic dermatitis
T. Hisamoto

121 Pharmacological inhibition of the neonatal Fc receptor reduces disease activity in an antibody transfer-induced model of bullous pemphigoid
M. Pigors

168 TLR7-VGLL3 synergism potentiates lupus-like autoimmunity in mice
O. Plazyo

056 IKZF1 and IKAROS overexpression contributes to the pathogenesis of alopecia areata
Y. Arakawa

039 Inhibitory effect on skin fibrosis by regulating Th17 and regulatory T cell imbalance in a systemic sclerosis mouse model and the involvement of alteration in the intestinal microbiota
A. Sekiguchi

014 Sex as a variable in the composition of skin residing T cells
H. Koguchi-Yoshioka

073 Arteriosclerosis derived from cutaneous inflammation is ameliorated by the deletion of IL-17A or IL-17F
T. Nakanishi

166 Granzyme K stimulates a novel pathway of complement activation
E. Theisen

079 Generation and characterization of the Psmb8 G201V mutation knock-in mice as a model for Nakajo-Nishimura syndrome
T. Hara

016 Immune competent skin organoids reveal monkeypox dynamics
A. J. Pavlovitch-Bedzyk

053 Conformational epitope mapping of autoantibodies against BP180 in dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid
S. Mai

075 Cellular subsets and signaling pathways of IgA vasculitis revealed by single-cell RNA sequencing
D. Tie

160 Local precursors are capable of replenishing tissue-resident memory T cells in healthy and diseased skin
E. Hoffer

002 Gene flow from archaic hominins causes psoriasis, ankylosing spondylitis, and Behçet’s disease
A. Arakawa

563 Increased incidence of cutaneous melanoma and merkel cell carcinoma in subgroups of patients with primary cutaneous B-cell lymphoma: A SEER database analysis
L. Banner

411 Associations between immune-related diseases and skin cancer: An analysis of the diverse All of US research program
E. M. Lin

475 Skin of color and mucocutaneous ulcers are associated with increased disease severity in anti-NXP2 dermatomyositis patients
C. Bax

485 Sleep disturbance impacts physical and psychosocial health of children with atopic dermatitis
C. Mann

461 Total serum IgE levels as a predictor for clinical response to omalizumab in patients with chronic spontaneous urticaria: A systematic review and meta-analysis
H. C. Chang

408 Disaggregated analysis of Asian ethnicities reveals disparities in melanoma treatment timeliness
L. S. Fane

561 Can systemic levels of BNP predict itch severity?
L. A. Nattkemper

442 The influence of psoriasis on clinical outcomes following burn Injury
D. Thomas

419 Comparison of topical fluorouracil and cryotherapy in Medicare patients with actinic keratoses: A retrospective cohort study
M. K. Nowakowska

565 Assessing postoperative complication risk in patients with pre-existing diabetes mellitus who undergo mohs micrographic surgery
D. Garate

473 Clinical characteristics and risk of second malignancies of extramammary paget’s disease patients in Canada and Japan
F. Al Ghazawi

463 Comorbid conditions associated with alopecia areata: A systematic review and update
S. Ly.

513 Zinc dyshomeostasis in patients with bullous pemphigoid and BP180-deficient mice
C. Chu

426 Association of stratum corneum and breast milk factors with the development of atopic dermatitis in infancy: A prospective birth cohort study
R. Fukuda

468 Use of calcitonin gene-related peptide monoclonal antibodies in patients with rosacea: An exploratory, comparative case series
T. Sia

392 Hair loss after drug reaction with eosinophilia and systemic symptoms: A multicentric retrospective study
J. Lee

452 Validation of LRINEC score and establishment of novel score in Japanese patients with necrotizing fasciitis
Y. Norimatsu

1458 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis
A. Ahmed

1446 RNase L acts as a regeneration suppressor
C. Kirby

1516 Genetic mouse models and a new pro-lymphangiogenic treatment approach reveal beneficial effects of lymphatic vessel activation in cutaneous wound healing
M. Detmar

1473 Hippo pathway drives excessive fibrosis in hidradenitis suppurativa
K. R. van Straalen

1479 The cutaneous ischemia-reperfusion injury-induced pressure ulcer was attenuated in amyotrophic lateral sclerosis mice model via decreased nerve neurons and neuro peptides resulting in suppressing oxidative stress.
A. Uchiyama

1539 A paradigm shift: Inflammatory response in chronic wounds halts progression of healing
M. Tomic-Canic

1468 Lymphatic dysfunction affects both collagen degradation and collagen synthesis, leading to a paradoxical reduction in dermal fibrosis
M. Sugaya

1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling
S. Sim

1482 Physical stress reveals stem cell resources in nail
H. Kosumi

1440 DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control keratinocyte differentiation and hair growth
G. Chen

1349 Inducing fate changes at the hair follicle stem cell nice
C. Clavel

1391 Cell death functions in hair follicle regeneration
G. Mantellato

1428 DKK2 and SOSTDC1 cooperate to initiate the first catagen phase of the hair follicle growth cycle
A. Ho

1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function.
S. Iriyama

1378 A multi-omics approach to identifying factors involved in hair follicle growth and development
N. Pantelireis

1346 Functional roles of Krox20 (Egr2) in Epithelial Stem Cells
E. Ghotbi

1413 From force to fate: LINCing cell junctions to nuclear morphology
A. Banerjee

291 Dysregulation of N6-methyladenine DNA methylation as a new epigenetic mechanism in skin tumorigenesis
Y. He

271 The invasive niche confers resistance to therapy in basal cell carcinoma
F. Kuonen

308 Immuno cancer-associated fibroblasts are a major source of cytokines in malignant skin cancer
B. Aschenbrenner

256 Non-canonical control of hedgehog signaling in skin basal cell carcinoma
R. Iglesias-Bartolome

232 Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy
H. Wong

236 Visualizing somatic alterations in spatial transcriptomics data of skin cancer
H. Shain

235 Distinct biological pathways associated with individual stages of tumor progression in KIT-altered melanoma
E. Everdell

293 Acidosis promotes immune escape through the IFN-γ-induced induction of PD-L1 transcription in cancer cells
D. Stowbur

274 Homologous recombination deficiency scores in AK and cSCC are associated with tumor-immune phenotype
J. Thomson

1178 Mechanisms of type I interferon-mediated UVB sensitivity in human keratinocytes
N. Haddadi

1170 Investigating the molecular mechanisms of solar urticaria
M. Peake

1175 Impact of low dose UVA radiation on UVB radiation-induced DNA damage and skin carcinogenesis
K. M. Rolfes,

1142 The IL-1α stimulated expression of the wrinkle-inducing elastase neprilysin in adult human dermal fibroblasts is mediated via an intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1
U. C. Pinnawala

1165 PDT-resistant skin tumor cells secrete CCL2 to induce TAMs recruitment and suppressive tumor microenvironment.
Y. Fu

1310 Characterization of differences in epidermal lipid composition between psoriatic skin of color and white psoriatic skin
R. Haughton

1317 S6K2 is a vulnerability in MAPK-driven acral melanoma
R. Brathwaite

1292 Molecular phenotyping of keloid skin samples suggests polar immune dysregulation
J. Bar

1314 The JAK/STAT signaling pathway: Considerations in the management of hidradenitis suppurativa in skin of color
C. A. Okeke

818 Multi-condition TWAS for inflammatory skin disorders highlights roles of genetic signals in cytokine-stimulated keratinocytes
H. Zhang

862 Hedgehog signaling and ENPP1 role in epidermal proliferation and melanin synthesis
M. Pavlovsky

903 Utilizing an organoid-based approach for the derivation of genetically corrected keratinocytes and fibroblasts in an induced pluripotent stem cell therapy for skin diseases
M. Pavlova

878 CRISPR/Cas9 targeting an intronic region retrieving protein expression in a compound heterozygous model mice via inducing revertant mosaicism pathways
H. Nguyen

803 Editing a missense to a nonsense keratin 9 gene mutation restores intermediate filament integrity
T. Trafoier

899 Phenotypic and genomic characterization of eight patients with patterned cutaneous hypopigmentation associated with extracutaneous findings
Z. Cai

825 Basement membrane proteins in NF1-associated neurofibroma extracellular matrix characterize tumor development and treatment response to MEK inhibitor
L. Q. Le

ePoster Discussion Session 2 - Friday 12 May - 18.10-19.40

205 Annotation-free deep learning identifies cellular neighborhoods associated with responses to immunotherapy in patients with melanoma
D. Jimenez-Sanchez

1597 Topical calcipotriol plus 5-fluorouracil immunotherapy eliminates premalignant skin lesions through a T helper 2 cell/interleukin-24 axis
V. Oliver-García

218 Predicting mortality in systemic sclerosis patients using machine learning approaches
A. Jang

1568 Identification of fibroinflammatory and fibrotic transcriptomic subsets of human sclerotic cutaneous chronic graft-versus-host disease
R. Rosenstein.

1620 The cutaneous somatic landscape of prurigo nodularis
A. Rajeh.

208 Deep learning–based automatic assessment and cluster analysis of atopic dermatitis: A model for predicting therapeutic efficacy
K. Nakamoto

1542 Allergen sensitization status stratifies IL-31 production by memory T cells in atopic dermatitis
L. Sans-De San Nicolàs

1544 Disruption of a pathologic, skin-resident T17 cell identity in clinically effective IL23 blockade of psoriasis
D. Wu

1244 Epigenetic & metabolic vulnerabilities of adaptive drug resistance to targeted therapies in melanoma
J. Torrano

1217 Itaconate inhibits dendritic cell and CD8+T cell-mediated autoimmune response and halts vitiligo depigmentation
Y. Wang,

1280 Melanin synthesis drives global reprogramming of cellular and tissue metabolism
J. Zippin

1209 The fate of melanocytes and the disorganization of basement membrane in a guinea pig model of rhododendrol-induced chemical vitiligo
Y. Kuroda

1234 Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma
G. Micevic

1250 Induction of tertiary lymphoid structures in a mouse melanoma model under a combination of CXCL13 and anti-PD-1 antibody
M. Yoshimitsu

1252 Interferon mediated resistance of melanoma cells to oncolytic viruses is regulated by the melanocyte lineage transcription factor MITF
S. Gellert

1199 PYK2 regulates PD-L1 expression via JAK/STAT signaling in melanoma
Y. Mizuno

1201 Single-cell, spatial profiling of heterogeneous melanocytic neoplasms
N. Love

954 Differential regulation of comedogenesis and folliculitis by free fatty acids metabolized by cutibacterium acnes: Comprehensive analysis of human acne subjects and animal model
T. Sugihira

1001 Gut bacterial sphingolipid production regulates the skin microbiome, skin lipid production and skin barrier homeostasis
T. A. Harris-Tryon

1037 Triggering receptor expressed on myeloid cells (TREM)-1 modulates cutaneous immune responses and prevents skin cancer
N. Yusuf

942 Inefficient senescent fibroblast clearance in aging skin: The contribution of impaired natural killer cells
A. Koroma

949 Lipopeptides derived from skin bacteria modulate the allergic response in human and mouse skin.
H. Williams

1020 Comprehensive search for therapeutic targets and understanding of fibrosis in hidradenitis suppurativa
T. Omine

965 The importance of CD206+ macrophages in squaric acid dibutylester-induced hair cycle activation.
K. Tomii

978 Modulation of IL-36-triggered signaling in skin keratinocytes by AMPK
N. Wu

955 Skin care improves newborn skin dysbiosis associated with atopic dermatitis
T. Ito

999 Gastrointestinal colonization as a source of staphylococcus aureus in atopic dermatitis
T. Karagounis.

1054 Circulating inflammatory monocytes associated with atopic dermatitis microbial-defined endotypes
J. Chen

908 T-cell receptor signaling and cellular metabolism regulate IL-13-producing capacity of murine epidermal γδ T cells
A. Ibusuki

911 Mature interleukin-36γ induces epidermal stratum corneum exfoliation in generalized pustular psoriasis via downregulation of corneodesmosine
E. Sato

1040 Calprotectin plays a role in regulating inflammatory cytokine production in human macrophages post-Cutibacterium acnes infection.
T. Hsu

969 Epidermis-specific deletion of miR-149 exacerbates psoriasis-like skin inflammation
E. Sonkoly

1004 Dermal extracellular matrix inhibits mast cell activation to skin commensal bacteria
A. Di Nardo

1015 Immunomodulatory roles of danger-associated molecular patterns in skin inflammation
S. Kumari

342 Single-cell RNA-seq reveals keratinocytes and fibroblasts are potential key cellular targets of IL-31 in prurigo nodularis
K. Katsuo

330 The aryl hydrocarbon receptor contributes to histamine-evoked itch with the involvement of TRPV1 in dorsal root ganglia
H. Yue

332 Extensive interactions between keratinocytes and immune cells in psoriatic epidermis revealed by single-cell transcriptomics
L. Luo

366 CD4+ T cells eradicate IFN-unresponsive melanomas that resist CD8+ T cell therapy
B. Kruse

362 Multiplexed spatial mapping of panniculitis: Deciphering the signatures of subcutaneous adipose tissue inflammation
R. Ziadlou

343 Exosomes containing miRNAs from keratinocytes under oxidative stress contribute to the destruction of melanocytes and CD8+ T cell activation in vitiligo
J. Ma

346 Leveraging skin immunity to counteract senescence
C. Mainzer

367 Inducible loss of claudin-1 in keratinocytes leads to the induction of itch transmitted by multiple types of sensory nerves
S. Toshima

331 UBE2L3 reduces interleukin-1β secretion in epidermal keratinocytes and deficiency of UBE2L3 results in spontaneous psoriasis-like dermatitis
X. Chen

748 Cutibacterium acnes supports the epidermal barrier by promoting epidermal lipid synthesis
R. L. Gallo

699 TEX264 drives autophagic degradation of the endoplasmic reticulum in keratinocytes during epidermal differentiation and upon ER stress
C. L. Simpson

788 Ferroptosis enhances epidermal cornification through transcriptional and metabolic reprogramming
N. Kuprasertkul

767 Znf750 regulates skin barrier functions independently of epidermal differentiation
I. Cohen

782 Fucosyltransferase 1 plays a protective role in the development of atopic dermatitis-like disease in mice
Y. Lee

727 Contact hypersensitivity in the absence of loricrin: A checkpoint of percutaneous adaptive immunity
Y. Ishitsuka

724 Loss of pinin induces differentiation of human epidermal keratinocytes
T. Makino

794 Region-specific differences in human epidermal differentiation at a single-cell level
J. Wiedemann

714 Stratum corneum homeostasis requires three-stepwise pH zones mediated by the functional cell death of keratinocytes, corneoptosis
K. Fukuda

1096 The PARP14 inhibitor RBN-3143 suppresses skin inflammation in preclinical models
M. Niepel

1093 A zinc deficiency enhances mu-opioid receptor-mediated pruritus
H. Sano

1063 Small molecule antagonists of interleukin 17 offer an orthogonal approach to inhibit key inflammatory processes
E. R. Goedken

1073 Fasudil ameliorates fibrosis and immune abnormalities in animal models of systemic sclerosis
T. Toyama

1106 Inhibition of cellular senescence by apocynin in human keratinocytes irradiated with ultraviolet b
T. Ansary

1129 Chemical engineering of therapeutic siRNAs for the modulation of gene expression following intradermal administration in the skin
K. Gross

1077 Efficacy and safety of ENERGI-F701 solution versus 2% minoxidil solution for female pattern hair loss: a phase II, multi-center, randomized, double-blind, head-to-head, parallel trial
S. Ma

1095 A2a regulates the polarization of M1 macrophages to initiate innate immunity in psoriasis
Y. Lu

676 Urgent care referrals demonstrate need for “real-time” dermatology e-consultation
S. Rahman

688 Using implementation science approaches to select and prioritize potential antibiotic stewardship interventions in acne
L. Chu

675 FDA advisory panel members recommend process improvements
U. Nadir

589 Patients with advanced melanoma who benefit from the addition of anti-CTLA-4 to anti-PD-1 have a distinct tumor microenvironment (TME)
N. M. D’Amiano

588 Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis
J. Clabbers

634 Assessing the effects of systemic therapy for vascular malformations using RNAseq
J. M. Teng

666 Patient-reported impact of dermatological diseases (PRIDD) measure: Pemphigus and pemphigoid delphi data
N. Trialonis-Suthakharan

671 Time-to-treatment and recurrence for head and neck Merkel cell carcinoma treated with Mohs micrographic surgery and sentinel lymph node biopsy
S. K. Lin.

680 Identification of environmental, demographic and lifestyle risk factors for cutaneous T cell lymphoma: A single institution case-control study
X. Zhou

LB1714 Increased epidermal penetration in aged skin modulates systemic inflammation
T. Mauro

LB1787 Tuning biomaterial stiffness augments innate and adaptive immune responses in the skin
J. S. Weinstein

LB1726 Pathogenic contribution of ADAR1 mutations to severe plaque psoriasis
F. Assan

LB1730 Concordance in the secretome of recessive dystrophic epidermolysis bullosa and cellular senescence reveals COL7A1 dependent perturbations
S. A. Koutsoukos

LB1758 Regulation of the Independent Skin Circadian Clock by Specific Opsin Using Human Skin Organotypic Culture
M. Bigliardi Qi

LB1799 Single-cell type proteomic analysis in FFPE tissue sections of severe cutaneous adverse drug reactions
T. Nordmann

LB1715 Beyond established protection: adaptive epidermal barrier functions regulate systemic energy metabolism and body composition
X. Ding

LB1632 PD-1 signaling plays a critical role for inhibiting development of autoimmune disease-associated dermatitis in childhood
K. Oya

LB1694 Social and environmental context impacts racial disparities in pediatric atopic dermatitis severity in the Unites States
J. Takeshita

LB1698 Phase 2 study of the safety and efficacy of QTORIN rapamycin in the treatment of microcystic lymphatic malformations
J. M. Teng

LB1709 Prevalence of skin cancer screening visits in Medicare data: a retrospective cohort study
M. K. Nowakowska

LB1750 PC111, an anti-FasL neutralizing antibody, blocks pemphigus blister formation in in-vitro, ex-vivo and in-vivo human models
R. Lotti

LB1774 Establishing competent morphogenetic fields for tissue pattern regeneration in skin organoids
M. Lei

LB1794 Mechanisms regulating scar-free wound healing in long-lived naked mole-rats
I. Fatima

LB1800 TWEAK-induced apoptosis depletes desmoglein 1 and 3 via STAT1 in pemphigus
Y. Liu

LB1790 RNAi-based topical formulation to treat chronic diabetic foot ulcers
P. Sampath

Poster Hall space in the NS Building

e-Poster discussion

How to get to the NS Building from the Keio Plaza hotel

NS Building

Posters 10-11 May 2023

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Posters 12-13 May 2023

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