Plenary talks are 10 minutes plus 2 minutes discussion
08.10-08.22 ORAL 101 [POSTER 025 ]
Interstitial lung disease based on autoimmunity against melanoma differentiation-associated gene 5
Y. Ichimura1, 3, R. Konishi1, 3, T. Nomura3, M. Fujimoto2, N. Okiyama1
1Department of Dermatology, Tokyo Ika Shika Daigaku Daigakin Ishigaku Sogo Kenkyuka, Bunkyo-ku, Tokyo, Japan, 2Department of Dermatology, Osaka Daigaku, Suita, Osaka, Japan, 3Department of Dermatology, Tsukuba Daigaku Igaku Iryokei, Tsukuba, Ibaraki, Japan
08.22-08.34 ORAL 102 [POSTER 1164 ]
Naive HIF-1a/ AhR keratinocyte-conditional double knockout mice resemble UVB-irradiated wildtype mice
S. Fassbender1, 2, J. Schindler1, 2, H. Ramachandran1, T. Nguyen1, M. Majora1, T. Haarmann-Stemmann1, C. Esser1, A. Rossi1, H. Weighardt2, 1, J. Krutmann1
1IUF – Leibniz-Institut fur umweltmedizinische Forschung GmbH, Dusseldorf, Nordrhein-Westfalen, Germany, 2LIMES Life and Medical Sciences Institute, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Nordrhein-Westfalen, Germany
08.34-08.46 ORAL 103 [POSTER 539 ]
Multi-organ toxicities are associated with improved survival among immune checkpoint inhibitor recipients: A population-level analysis
W. Chen1, 2, G. Wan1, 2, K. Roster1, N. Nguyen1, A. Rajeh1, H. Rashdan1, M. Collier1, J. Seo1, N. LeBoeuf4, 2, S. Kwatra3, Y. Semenov1, 2
1Massachusetts General Hospital, Boston, Massachusetts, United States, 2Harvard Medical School, Boston, Massachusetts, United States, 3Johns Hopkins University, Baltimore, Maryland, United States, 4Dana-Farber Cancer Institute, Boston, Massachusetts, United States
08.46-08.58 ORAL 104 [POSTER 225 ]
Enhanced TLR7 immunity drives innate protection against SARS-CoV-2 with chilblains as collateral damage.
A. Yatim1, 2, 3, F. Saidoune1, J. Di Domizio1, R. Jenelten1, A. Joncic1, M. Morren1, C. Conrad1, J. Casanova2, 3, M. Gilliet1
1Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud, Switzerland, 2Institut Imagine Institut des Maladies Genetiques, Paris, Île-de-France, France, 3The Rockefeller University, New York, New York, United States
08.58-09.10 ORAL 105 [POSTER 732 ]
Dysregulated cytosolic Ca2+ concentration in channel-related keratoses
T. Murata1, 2, N. Kanazawa1, K. Kabashima2
1Department of Dermatology, Hyogo Medical University, Nishinomiya, Japan, 2Department of Dermatology, Kyoto University, Kyoto, Japan
Plenary talks are 10 minutes plus 2 minutes discussion
10.20-10.32 ORAL 106 [POSTER 916 ]
Activation of the pentose phosphate pathway in macrophages is essential for granuloma formation in sarcoidosis
S. Nakamizo1, G. Egawa1, Y. Ishida1, Y. Sugiura1, K. Kabashima1, 2
1Kyoto Daigaku, Kyoto, Japan, 2Agency for Science, Technology and Research, Singapore, Singapore
10.32-10.44 ORAL 107 [POSTER 1124 ]
Strong preclinical evidence for treatment efficacy of a novel immune checkpoint inhibitor (ICI) in melanoma that targets a rare heparan sulfate
J. Chung1, 2, S. Ung1, 2, J. Gill1, P. Cruz1, 2, K. Ariizumi1, 2
1Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2North Texas VA Medical Center, Dallas, Texas, United States
10.44-10.56 ORAL 108 [POSTER 1431 ]
Skin aging and hair follicle stem cell dysfunction caused by T cells with defective mitochondrial metabolism
E. Carrasco1, 2, 3, E. Gabandé-Rodríguez2, 4, G. Soto-Heredero2, 4, M. M. Gómez de las Heras2, 4, M. Mittelbrunn2
1Department of Biology, Faculty of Sciences, Universidad Autonoma de Madrid, Madrid, Spain, 2Tissue and Organ Homeostasis Program, Universidad Autonoma de Madrid Centro de Biologia Molecular Severo Ochoa, Madrid, Spain, 3Experimental Dermatology, Instituto Ramon y Cajal de Investigacion Sanitaria, Madrid, Spain, 4Department of Molecular Biology, Faculty of Sciences, Universidad Autonoma de Madrid, Madrid, Spain
10.56-11.08 ORAL 109 [POSTER 017 ]
A novel therapeutic strategy using stabilized antigen-specific iTreg for pemphigus
M. Mukai1, H. Takahashi1, N. Mikami2, S. Sakaguchi2, M. Amagai1
1Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Experimental Immunology, Osaka University IFReC, Osaka, Japan
11.08-11.20 ORAL 110 [POSTER 1567 ]
Single-cell rna sequencing reveals unique fibroblast subclusters in prurigo nodularis
J. R. Patel1, M. Joel1, K. Lee1, A. Kambala1, H. Cornman1, O. O. Oladipo1, M. Taylor1, J. Deng1, V. Parthasarathy1, M. Marani1, S. Reddy1, T. Pritchard1, V. Rebecca1, W. Ho1, M. Kwatra2, X. Dong1, S. Kang1, S. Kwatra1
1Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2Duke University School of Medicine, Durham, North Carolina, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
15.30-15.40 ORAL 111 [POSTER 157 ]
The tumor microenvironment limits the development and persistence of tissue-resident memory T cells
J. B. Williams, T. S. Kupper
Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, United States
15.40-15.50 ORAL 112 [POSTER 007 ]
Commensal papillomaviruses role in sun-damaged skin homeostasis
H. G. Son1, D. T. Ha1, R. Guennoun1, J. Strickley1, T. H. Erlich1, D. E. Fisher1, J. Joh2, S. Demehri1
1CBRC, Massachusetts General Hospital, Boston, Massachusetts, United States, 2University of Louisville, Louisville, Kentucky, United States
15.50-16.00 ORAL 113 [POSTER 143 ]
Genetic and transcriptional signatures of merkel cell carcinoma-specific B cells suggest a functional role in modulating cancer immunity
A. J. Remington1, 2, H. J. Rodriguez1, 2, T. Pulliam1, M. D. Gray2, J. J. Taylor2, P. Nghiem1
1Division of Dermatology, University of Washington, Seattle, Washington, United States, 2Vaccine and Infectious Disease Divison, Fred Hutchinson Cancer Center, Seattle, Washington, United States
16.00-16.10 ORAL 114 [POSTER 084 ]
Neoantigen-specific T cell responses constrain cutaneous squamous cell carcinoma
A. C. Adams1, A. M. Macy1, E. S. Borden1, L. M. Herrmann1, K. H. Buetow2, M. A. Wilson2, D. J. Roe3, K. T. Hastings1
1College of Medicine – Phoenix, University of Arizona, Phoenix, Arizona, United States, 2School of Life Sciences, Arizona State University, Tempe, Arizona, United States, 3Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States
16.10-16.20 ORAL 115 [POSTER 150 ]
Single-cell RNA sequencing defines disease-specific differences between prurigo nodularis and atopic dermatitis
N. Alkon1, F. P. Assen1, T. Arnoldner1, W. M. Bauer1, M. Medjimorec1, L. Shaw1, K. Rindler1, G. Holzer2, P. Weber1, W. Weninger1, T. Kinaciyan1, M. Farlik1, C. Jonak1, J. Griss1, C. Bangert1, P. Brunner3
1Medizinische Universitat Wien, Wien, Austria, 2Klinik Donaustadt, Vienna, Austria, 3Icahn School of Medicine at Mount Sinai, New York, New York, United States
16.20-16.30 ORAL 116 [POSTER 042 ]
T cell-derived lymphotoxin β receptor signaling forms HEV-like vessels in the skin of atopic dermatitis-like inflammation in mice
S. Kanameishi1, S. Ono1, Y. K. Honda1, 3, R. Asahina1, T. Honda2, K. Kabashima1
1Dermatology, Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu, Kyoto, Kyoto, Japan, 2Dermatology, Hamamatsu Ika Daigaku, Hamamatsu, Shizuoka, Japan, 3Immunology Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
16.30-16.40 ORAL 117 [POSTER 055 ]
IL-15 contributes to atopic dermatitis pathogenesis: Lessons from a novel humanized mouse disease model
I. Piccini1, O. Egriboz1, K. I. Pappelbaum1, M. Fehrholz1, A. Keren2, R. Paus1, 3, 5, A. Gilhar2, A. Vicari4, M. Bertolini1
1Monasterium Laboratory GmbH, Münster, Germany, 2Technion Israel Institute of Technology, Haifa, Israel, 3Dermatology, University of Miami, Miami, Florida, United States, 4Calypso Biotech BV, Amsterdam, Netherlands, 5CUTANEON, Hamburg, Germany
16.40-16.50 ORAL 118 [POSTER 167 ]
IL-36 axis is female-biased in pustular psoriasis in type I IFN-dependent manner
M. Sarkar1, F. Ma2, 1, A. Kidder1, A. Coon1, B. E. Perez White3, R. Uppala1, N. L. Ward4, C. Dobry1, L. Tsoi1, J. M. Kahlenberg2, J. Gudjonsson1
1Dermatology, University of Michigan, Ann Arbor, Michigan, United States, 2Rheumatology, Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States, 3Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 4Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, United States
16.50-17.00 ORAL 119 [POSTER 057 ]
Single-cell RNA sequencing reveals cellular drivers of UV-mediated skin injury in cutaneous lupus
M. P. Maz, F. Ma, M. Gharaee-Kermani, A. Victory, A. Hurst, J. Gudjonsson, J. M. Kahlenberg
University of Michigan, Ann Arbor, Michigan, United States
17.00-17.:10 ORAL 120 [POSTER 094 ]
Periostin – an inducer of pro-fibrotic phenotype in monocytes and monocyte-derived macrophages in systemic sclerosis
M. Suzuki, Y. Ototake, A. Akita, M. Asami, N. Ikeda, Y. Yamaguchi
Yokohama Shiritsu Daigaku Igakubu Daigakuin Igaku Kenkyuka, Yokohama, Kanagawa, Japan
17.10-17.20 ORAL 121 [POSTER 128 ]
A stable, but reversible replicative arrest in alopecia areata
K. Meier1, 2, J. Brück2, T. Mehra3, M. Gassenmaier2, E. Müller-Hermelink1, 2, A. Hossini4, C. C. Zouboulis4, K. Ghoreschi1, 2, M. Röcken2
1Department of Dermatology, Venereology and Allergology, Charite Universitatsmedizin Berlin, Berlin, Germany, 2Department of Dermatology, Eberhard-Karls-Universitat Tubingen Medizinische Fakultat, Tubingen, Baden-Württemberg, Germany, 3Kantonsspital Baselland, Liestal, Basel-Landschaft, Switzerland, 4Department of Dermatology, Venereology, Allergology and Immunology, Stadtisches Klinikum Dessau, Dessau, Sachsen-Anhalt, Germany
17.20-17.30 ORAL 122 [POSTER 169 ]
Vitiligo lesions are driven by the collaboration of expanded CD8+ T cell clones
E. Katz1, A. Manukyan1, K. Gellatly1, M. Wadsworth2, A. Winkler2, W. Ruff3, M. Garber1, J. E. Harris1
1University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 2Pfizer Inc, New York, New York, United States, 3Repertoire, Cambridge, Massachusetts, United States
17.30-17.40 ORAL 123 [POSTER 181 ]
The role of nuclear IL-37 in regulating FOXP3 expression and Treg cell stability
D. Osborne1, J. Domenico1, P. K. Vaddi1, Z. Zhai1, C. Dinarello2, 3, M. Fujita1, 3, 4
1Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 2Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 3Immunology & Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 4Veterans Affairs Medical Center, VA Eastern Colorado Health Care System, Aurora, Colorado, United States
17.40-17.50 ORAL 124 [POSTER 095 ]
HLA class II-restricted CD8+ T cells contribute to the promiscuous immune response in dapsone hypersensitive patients
Q. Zhao1, L. Sun1, H. Liu1, D. Naisbitt2, F. Zhang1
1Shandong Provincial Hospital for Skin Diseases, Jinan, Shandong, China, 2University of Liverpool, Liverpool, United Kingdom
17.50-18.00 ORAL 125 [POSTER 097 ]
VDAC as a novel actionable therapeutic target in pemphigus vulgaris
S. Assaf1, 2, O. Sarig1, C. Bilu1, Y. Zoabi2, K. Malovitski1, 2, Y. Feller1, 2, S. Bergson1, 2, V. Shoshan-Barmatz3, N. Shomron2, D. Vodo1, E. Sprecher1, 2
1Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel, 3Ben-Gurion University of the Negev, Beer-Sheva, Israel
Concurrent talks are 8 minutes plus 2 minutes discussion
15.30-15.40 ORAL 126 [POSTER 402 ]
Antihypertensive medication associated with eczematous dermatitis in older adults
M. Ye1, I. Douglas2, S. Evans2, S. M. Langan2, K. Abuabara1
1Department of Dermatology, University of California San Francisco, San Francisco, California, United States, 2London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health, London, London, United Kingdom
15.40-15.50 ORAL 127 [POSTER 488 ]
Dual blockade of IL-4 and IL-13 with dupilumab reduces severity of type 2 inflammatory immune-related adverse events
C. Lee1, W. Chung2, C. Chen2
1Department of Medical Education, Chang Gung Memorial Hospital, Keelung, Taiwan, 2Drug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, Taiwan
15.50-16.00 ORAL 128 [POSTER 550 ]
Atopic dermatitis in adolescents: Role of carbonyl reductase 3 genetic risk score under constant chronic exposure to particulate matter
S. Kress1, M. Lau2, C. Wigmann1, F. Hartung1, T. Haarmann-Stemmann1, T. Schikowski1
1IUF Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany, 2Heinrich-Heine-Universitat Dusseldorf, Dusseldorf, Nordrhein-Westfalen, Germany
16.00-16.10 ORAL 129 [POSTER 462 ]
Blood molecular phenotypes of Chinese AD patients
Y. Wang1, Y. Wu1, C. Gu1, X. Yao2, W. Li1
1Department of Dermatology, Huashan Hospital Fudan University, Shanghai, China, 2Department of Allergy and Rheumatology, Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China
16.10-16.20 ORAL 130 [POSTER 382 ]
A novel assessment of cardiovascular health in people with psoriasis in the US: a cross-sectional study
S. Wang1, D. B. Shin1, T. Bhutani2, J. Gelfand1
1Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2Dermatology, University of California San Francisco, San Francisco, California, United States
16.20-16.30 ORAL 131 [POSTER 484 ]
The relative abundance of unsaturated fatty acid and their dietary habits in incident psoriatic diseases
Y. Xiao2, D. Jing2, S. Yang2, X. Chen2, M. Shen1
1Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan, China, 2Dermatology, Central South University, Changsha, Hunan, China
16.30-16.40 ORAL 132 [POSTER 509 ]
IL-17A and IL-17F in the pathogenesis of hidradenitis suppurativa: Insights from early and chronic lesions
A. Skelton1, H. Gopee2, R. Okoye1, A. Ferecsko1, M. Page1, S. Shaw1
1UCB Pharma, Slough, United Kingdom, 2Newcastle University, Newcastle upon Tyne, United Kingdom
16.40-16.50 ORAL 133 [POSTER 447 ]
Immunotherapy efficacy in Merkel cell carcinoma is affected by the presence and type of immunosuppression: Analysis of 183 patients
E. Gong1, D. S. Hippe1, X. Fan1, L. Zawacki1, 2, A. J. Remington1, A. Menon1, K. Lachance1, T. Akaike1, S. Park1, P. Nghiem1
1University of Washington, Seattle, Washington, United States, 2Washington State University, Pullman, Washington, United States
16.50-17.00 ORAL 134 [POSTER 430 ]
Merkel cell carcinoma and multiple primary cancers: A SEER-based analysis
E. Eid1, N. Maloney2, Z. Ran Cai1, L. Zaba2, N. Kibbi2, E. M. John3, E. Linos2
1Program for Clinical Research and Technology, Stanford University, Stanford, California, United States, 2Department of Dermatology, Stanford University, Stanford, California, United States, 3Department of Epidemiology & Population Health, Stanford University, Stanford, California, United States
17.00-17.10 ORAL 135 [POSTER 520 ]
A retrospective cohort study of patch testing in oral lichen planus and subsequent diagnosis of oral squamous cell carcinoma.
V. N. Sahni, Z. Hopkins, J. Rhoads, J. Clarke, C. Hansen, D. Powell, R. deShazo, J. Zone, C. Hull
Dermatology, University of Utah Health, Salt Lake City, Utah, United States
17.10-17.20 ORAL 136 [POSTER 508 ]
Prognostic relevance of blood T-cell clonality in mycosis fungoides
D. Joffe, L. Banner, L. Gleason, N. Nikbakht
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
17.20-17.30 ORAL 137 [POSTER 410 ]
Clinicopathological factors and outcomes of cutaneous angiosarcoma
S. Yonekura, Y. Endo, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
17.30-17.40 ORAL 138 [POSTER 571 ]
Associations among polymorphisms in FCγRIIIA and treatment responses to rituximab in patients with pemphigus
P. Huang, Y. Cho, C. Chu
Department of Dermatology, National Taiwan University, Taipei, Taiwan
17.40-17.50 ORAL 139 [POSTER 522 ]
Serum levels of alarmins as potential biomarkers to diagnose and predict activity/severity of non-segmental vitiligo
K. He1, W. Wu1, X. Wang1, W. Dai2, S. Wang2, C. Li1, S. Li1
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, China, Xi’an, Shaanxi, China, 2Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China
17.50-18.00 ORAL 140 [POSTER 445 ]
Higher ambient temperature contributes to extrinsic skin aging
N. Singh, S. Grether-Beck, T. Schikowski, J. Krutmann
IUF Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany
Concurrent talks are 8 minutes plus 2 minutes discussion
15.30-15.40 ORAL 141 [POSTER 943 ]
Loss of both host-derived antimicrobial peptides and bacteriocin-producing commensals enables survival of Staphylococcus aureus on Th2-inflamed skin
T. Nakatsuji, S. Brinton, K. Cavagnero, T. Dokoshi, A. O’Neill, R. L. Gallo
Dermatology, University of California San Diego, La Jolla, California, United States
15.40-15.50 ORAL 142 [POSTER 950 ]
Epicutaneous staphylococcus aureus exposure triggers lung inflammation via epithelia-intrinsic IL-36R signaling
S. Nolan, Y. Saito, D. Dikeman, C. Pontaza, M. Ahmadi, C. Youn, J. Zhang, N. Archer
Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
15.50-16.00 ORAL 143 [POSTER 933 ]
Staphylococcus aureus reversibly regulates Agr quorum sensing to cause an outbreak in a hospital
Y. Yamazaki1, H. Takahashi2, A. Takaya3, Y. Matsuoka-Nakamura1, 4, M. Fujimoto1
1Dermatology, Graduate School of Medicine, Osaka University, Suita, Japan, 2Medical Mycology Research Center, Chiba, Japan, 3Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan, 4Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, Suita, Japan
16.00-16.10 ORAL 144 [POSTER 906 ]
A novel IL-31-generating mechanism in atopic dermatitis: essential roles of macrophages in cooperation with basophils, thymic stromal lymphopoietin and periostin
T. Hashimoto, T. Satoh
Dermatology, Boei Ika Daigakko, Tokorozawa, Saitama, Japan
16.10-16.20 ORAL 145 [POSTER 974 ]
Decreased epidermal thickening by imiquimod in mice with conditional aryl hydrocarbon receptor ablation in langerhans cells: A potential role of autophagy by dysregulated AhR activation in psoriasis
C. Hong1, C. Lee2
1Dermatology, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung, Taiwan
16.20-16.30 ORAL 146 [POSTER 963 ]
Linear ubiquitin chain assembly complex (LUBAC) is involved in the development of murine imiquimod (IMQ)-induced and IL-23-induced psoriasis models
K. I. Kosaka1, S. Nakamizo1, G. Egawa1, K. Iwai2, K. Kabashima1
1Departments of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Molecular and Cellular Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
16.30-16.40 ORAL 147 [POSTER 968 ]
A role for immunity to the microbiota in nerve overgrowth display in psoriasis skin
J. Delaleu2, 1, M. Nagai1, L. Sun1, N. Bouladoux1, I. Gribonika1, D. Corral1, A. Wells1, P. Kulalert1, V. Link1, M. Enamorado1, Y. Belkaid1
1LHIM, National Institutes of Health, Bethesda, Maryland, United States, 2Hopital Saint Louis, Dermatology Department, Universite Paris Cite, Paris, Île-de-France, France
16.40-16.50 ORAL 148 [POSTER 958 ]
Diversely polarized macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease
J. Strobl1, 2, 3, L. Gail3, 1, L. Krecu1, S. Mahdad2, L. Kleissl1, P. Wohlfarth4, H. Knaus4, W. Rabitsch4, M. Haniffa2, 5, G. Stary1, 3
1Department of Dermatology, Medizinische Universitat Wien, Wien, Austria, 2Wellcome Sanger Institute, Hinxton, Cambridgeshire, United Kingdom, 3CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 4Bone Marrow Transplantation, Medizinische Universitat Wien Universitatsklinik fur Innere Medizin I, Wien, Austria, 5Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom
16.50-17.00 ORAL 149 [POSTER 1005]
Low levels of IL-13 are constitutively produced in healthy skin and locally imprint a pro-type 2 immune response
J. Mayer1, 2, K. Hilligan2, 4, D. Eccles2, S. Old2, R. Domingues3, M. Hepworth3, O. Lamiable2, F. Ronchese2
1Department of Dermatology and Allergology, Philipps-Universitat Marburg Fachbereich Medizin, Marburg, Germany, 2Malaghan Institute of Medical Research, Wellington, New Zealand, 3The University of Manchester, Manchester, United Kingdom, 4National Institutes of Health, Bethesda, Maryland, United States
17.00-17.10 ORAL 150 [POSTER 925 ]
Peripheral sensory neurons contribute to dermatitis induced by staphylococcus aureus cell wall components via the migration of basophils
H. Irie1, C. Nakashima2, A. Otsuka2, Y. Ishida1, K. Kabashima1
1Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan, 2Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan
17.10-17.20 ORAL 151 [POSTER 948 ]
The topical TLR8 agonist resiquimod restores defective nucleotide sensing in CTCL
C. Chen1, N. Smith2, C. Villani2, P. Chaskar3, J. Krishnaswamy3, J. Teague1, A. Gehad1, L. Gray1, N. Gerard1, A. Rook4, R. Clark1
1Brigham and Women’s Hospital, Boston, Massachusetts, United States, 2Massachusetts General Hospital, Boston, Massachusetts, United States, 3Galderma SA, Lausanne, Switzerland, 4University of Pennsylvania, Philadelphia, Pennsylvania, United States
17.20-17.30 ORAL 152 [POSTER 1028 ]
Cathelicidin peptide LL37 complexed to dsRNA induces the release of interleukin-36γ from human primary keratinocytes
J. Keller1, 4, J. Danis2, E. Girousi1, 4, J. Börold1, 4, M. Szell2, L. E. French3, T. M. Kündig1, 4, M. Mellett1, 4
1Dermatology, UniversitatsSpital Zurich, Zurich, Switzerland, 2Dermatological Research Group, Szegedi Tudomanyegyetem, Szeged, Csongrád, Hungary, 3Dermatology, Ludwig-Maximilians-Universitat Munchen Medizinische Fakultat, Munchen, Bayern, Germany, 4Universitat Zurich Medizinische Fakultat, Zurich, ZH, Switzerland
17.30-17.40 ORAL 153 [POSTER 980 ]
Demodex mites reveal an unanticipated expansion of innate lymphoid-like cells in immunodeficient mice
E. Arouge1, A. Subramanian1, A. Schroeder2, V. Cortez2, C. O’Leary3, R. R. Ricardo-Gonzalez1, 4, 5
1Dermatology, University of California San Francisco, San Francisco, California, United States, 2University of California San Francisco Department of Medicine, San Francisco, California, United States, 3Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States, 4Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States, 5Chan Zuckerberg Biohub, San Francisco, California, United States
17.40-17.50 ORAL 154 [POSTER 937 ]
Disruption of the innate lymphoid cell network alters the hair cycle during induced anagen
K. Sakamoto1, 2, O. Ayush1, S. Jin3, 1, S. Goel1, A. Sekiguchi1, T. Honda2, K. Nagao1
1Dermatology Branch, NIAMS, National Institutes of Health, Bethesda, Maryland, United States, 2Dermatology, Hamamatsu Ika Daigaku, Hamamatsu, Shizuoka, Japan, 3Dermatology, Seoul National University, Gwanak-gu, Seoul, Korea (the Republic of)
17.50-18.00 ORAL 155 [POSTER 975 ]
Skin inflammation disrupts intestinal antimicrobial activity and the gut microbiome
T. Dokoshi1, G. Rahman1, K. Cavagnero1, S. Brinton1, H. Schwarz1, Y. Nakamura1, Y. Chen1, N. Salzman2, R. Knight1, R. L. Gallo1
1University of California San Diego, La Jolla, California, United States, 2Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
15.30-15.40 ORAL 156 [POSTER 1064 ]
Desmoglein 2 is a safe and universal CAR-T cell therapy target in solid cancers
R. D. Carlson1, S. A. Waldman1, M. G. Mahoney2, A. E. Snook1
1Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States, 2Dermatology & Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
15.40-15.50 ORAL 157 [POSTER 1109 ]
First-in-class oral peptide systemically targeting the IL-23 pathway
A. Fourie1, X. Cheng2, L. Chang1, C. Greving1, A. Patrick1, B. Knight1, D. Polidori1, R. Patch1, A. Bhandari2, D. Liu2, K. Huie2, S. Li2, M. Rodriguez1, A. Kannan1, J. Sherlock1, N. Modi2
1Janssen Research and Development LLC, Raritan, New Jersey, United States, 2Protagonist Therapeutics Inc, Newark, California, United States
15.50-16.00 ORAL 158 [POSTER 1060 ]
IMG-008, a potent anti-human IL-36R antagonistic antibody, inhibits IL-36R-mediated inflammation
R. Lei1, P. Fan1, M. Zhang1, Y. Wang1, C. Guo1, J. Wang2
1Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd., Hangzhou, Zhejiang, China, 2Inmagene LLC, San Diego, California, United States
16.00-16.10 ORAL 159 [POSTER 1065 ]
The topical AhR agonist tapinarof has broad in vivo immunosuppressive and immunomodulatory effects in human skin grafted mice
G. Brito, A. Gehad, J. Teague, C. Chen, W. Crisler, L. Gray, I. Kim, R. Clark
Brigham and Women’s Hospital, Boston, Massachusetts, United States
16.10-16.20 ORAL 160 [POSTER 1075 ]
Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in atopic dermatitis
M. Sasakura1, H. Urakami1, K. Tachibana1, K. Ikeda1, D. Ennishi2, S. Tomida2, S. Morizane1
1Department of Dermatology, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Japan, 2Center for Comprehensive Genomic Medicine, Okayama Daigaku Byoin, Okayama, Japan
16.20-16.30 ORAL 161 [POSTER 1104 ]
Novel and selective TRPV3 inhibitors as new potential treatments for keratodermas and itch
E. Brener1, T. Mashriki1, M. McGrath2, L. Marchal2, E. Ella1, M. Moran1, S. Leibman Barak1, B. Vaisman1, D. Terkieltaub1, N. Schutz1, A. Hovnanian2, L. Braiman1
1Kamari Pharma Ltd., Ness Ziona, Israel, 2Institut Imagine Institut des Maladies Genetiques, Paris, Île-de-France, France
16.30-16.40 ORAL 162 [POSTER 1111 ]
Topical γ-linolenic acid restores skin barrier dysfunction and ameliorates atopic dermatitis in hairless mice
M. Fujii1, S. Ohya1, 2, T. Nabe1, 3
1Pharmacology, Kyoto Yakka Daigaku, Kyoto, Japan, 2Pharmacology, Nagoya Shiritsu Daigaku, Nagoya, Aichi, Japan, 3Immunopharmacology, Setsunan Daigaku, Neyagawa, Osaka, Japan
16.40-16.50 ORAL 163 [POSTER 1101 ]
Tapinarof, a therapeutic AHR-modulating agent, induces semaphorin 3A production via NRF2 in human keratinocytes: Implications for atopic dermatitis
G. Tsuji1, A. Takai-Yumine1, M. Takemura1, K. Yamamura1, T. Ito2, M. Kido-Nakahara2, T. Nakahara1, 2
1Research and Clinical Center for Yusho and Dioxin, Kyushu Daigaku Byoin, Fukuoka, Japan, 2Dermatology, Kyushu Daigaku Igakubu Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan
16.50-17.00 ORAL 164 [POSTER 1099 ]
Rational development of JAK1-selective siRNA therapeutics for the treatment of autoimmune skin diseases
Q. Tang1, 2, H. Fakih2, M. Zain Ul Abideen2, K. Afshari1, K. Gross2, J. Alterman2, A. Khvorova2, J. E. Harris1
1Dermatology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 2RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States
17.00-17.10 ORAL 165 [POSTER 1078 ]
Topical administration of MDI1228, a novel pan-JAK inhibitor, effectively suppresses the development of skin inflammation in mice
Y. Liu, M. Yin, Y. Yang, L. Zhang
School of Pharmaceutical Science, Xiamen University, Xiamen, Fujian, China
17.10-17.20 ORAL 166 [POSTER 1116 ]
Novel androgen receptor degrader for androgenetic alopecia (AGA) application
C. Chou, C. Liu, P. Liu, P. Cheng, H. Chen, K. Chen, C. Lin
AnHorn Medicines Co., Ltd., Taipei, Taiwan
17.20-17.30 ORAL 167 [POSTER 1069 ]
Fate induction in CD8 chimeric antigen receptor T cells through asymmetric cell division
C. Ellebrecht1, 2, C. Lee1, 2, A. R. Kelly2, 3, C. Berry1, 2, S. Oh1, 2, R. O’Connor2, 3, A. Payne1, 2
1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States, 2Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
17.30-17.40 ORAL 168 [POSTER 1126 ]
A pilot of a microdevice for in situ candidate drug screening in cutaneous lesions of T-cell lymphoma
K. Awh1, 2, C. J. Fay1, 2, N. LeBoeuf1, 2, O. Jonas3, C. Larocca1, 2
1Brigham and Women’s Hospital Department of Dermatology, Boston, Massachusetts, United States, 2Cutaneous Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States, 3Brigham and Women’s Hospital Department of Radiology, Boston, Massachusetts, United States
17.40-17.50 ORAL 169 [POSTER 1089 ]
Targeting right open reading frame protein kinase 3 (RIOK3) for the modulation of type III IFN in skin.
M. Diaz1, M. Diaz1, J. Kreitinger1, T. C. Bisom2, J. Lodmell3, P. Diaz1, 4
1DermaXon, Missoula, Montana, United States, 2Dept. of Chemistry and Biochemistry, University of Montana College of Humanities and Sciences, Missoula, Montana, United States, 3Division of Biological Sciences, University of Montana College of Humanities and Sciences, Missoula, Montana, United States, 4Department of Biomedical and Pharmaceutical Sciences, University of Montana College of Health, Missoula, Montana, United States
17.50-18.00 ORAL 170 [POSTER 1098 ]
Anti-inflammatory and antibacterial drug delivery nanocarriers for the topical treatment of MRSA-induced systemic and localized infections
Y. Chang1, C. Lin1, T. Huang1, 2, 3, J. Fang1, 2, 3
1Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan, 2Department of Anesthesiology, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan, 3Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Gueishan, Taoyuan, Taiwan
Concurrent talks are 8 minutes plus 2 minutes discussion
15.30-15.40 ORAL 171 [POSTER 1161 ]
UV irradiation modulates appetite and body weight through upregulating norepinephrine in mice
Q. Quan1, 2, 3, E. Kim1, 2, 3, Y. Kim1, 2, 3, S. Kim1, 2, 3, M. Chung1, 2, 3, Y. Tian1, 2, 3, C. Shin1, 2, 3, D. Lee1, 2, 3, J. Chung1, 2, 3
1Dermatology, Seoul National University College of Medicine, Seoul, Korea (the Republic of), 2Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of), 3Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea (the Republic of)
15.40-15.50 ORAL 172 [POSTER 1163 ]
Skin commensal bacteria modulate ultraviolet radiation-induced cytokine secretion in human keratinocytes
H. Serrage1, M. Farrar1, A. J. Mcbain1, J. Pennock1, C. Deng1, C. O’Neill1, 2
1The University of Manchester, Manchester, United Kingdom, 2Skin BioTherapeutics PLC, Newcastle, United Kingdom
15.50-16.00 ORAL 173 [POSTER 1146 ]
Mitochondrial dysfunction in xeroderma pigmentosum type A (XPA) causes UV-induced collapse of proteostasis due to lack of ATP
M. Majora, R. Bhattacharjee, S. Dangeleit, A. Rossi, J. Krutmann
IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
16.00-16.10 ORAL 174 [POSTER 1136 ]
Xeroderma Pigmentosum: From disease modeling using CRISPR-Cas9 technology to the understanding of skin cancers pathophysiology
A. Nasrallah1, F. Kobaisi1, S. Bourgoin-Voillard2, F. Clement1, X. Gidrol1, M. Seve2, E. Sulpice1, W. Rachidi1
1Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France, Grenoble, France, 2Univ. Grenoble Alpes, CNRS, TIMC U5525, EPSP 38000 Grenoble, France, Grenoble, France
16.10-16.20 ORAL 175 [POSTER 1145 ]
Evidence that microvesicle particles mediate the photosensitivity associated with xeroderma pigmentosum A deficiency
P. Manjrekar, L. R. Christian, C. Rapp, K. M. Henkels, R. Annamraju, Y. Chen, J. Travers
Pharmacology & Toxicology, Wright State University Boonshoft School of Medicine, Dayton, Ohio, United States
16.20-16.30 ORAL 176 [POSTER 1166 ]
Kinome siRNA screening for the treatment of the XPC cancer-prone disease
F. Kobaisi1, E. Sulpice2, A. Nasrallah1, X. Gidrol2, W. Rachidi1
1Universite Grenoble Alpes, Saint-Martin-d’Heres, Auvergne-Rhône-Alpes , France, 2IRIG, Commissariat a l’energie atomique et aux energies alternatives Siege administratif, Grenoble, France
16.30-16.40 ORAL 177 [POSTER 1168 ]
Neutrophil cytokines and NETs mediate skin and kidney inflammation in lupus flare under UVB irradiation
X. Lyu1, M. Li1, P. Zhang2, W. Wei1, V. P. Werth3, M. Liu3
1Tianjin Medical University, Tianjin, China, 2Beaumont Health, Royal oak, Michigan, United States, 3University of Pennsylvania, Philadelphia, Pennsylvania, United States
16.40-16.50 ORAL 178 [POSTER 1156 ]
Single-cell RNA sequencing of photoaged skin reveals SLC46A2 as potential cGAMP transporter in keratinocytes
D. J. Kim1, A. Billi3, A. Chien2, G. J. Fisher3, J. J. Voorhees3, J. Gudjonsson3, S. Kang2
1Yale School of Medicine, New Haven, Connecticut, United States, 2Johns Hopkins Medicine, Baltimore, Maryland, United States, 3University of Michigan, Ann Arbor, Michigan, United States
16.50-17.00 ORAL 179 [POSTER 1291 ]
Tralokinumab improves signs, symptoms, and key biomarkers in patients of different racial subgroups with atopic dermatitis
A. Alexis1, A. Blauvelt2, A. Armstrong3, L. Kircik4, K. Kabashima5, N. Katoh6, B. Esdaile7, M. Røpke8, A. Kurbasic8, S. Schneider9, E. Guttman-Yassky4
1Weill Cornell Medicine, New York, New York, United States, 2Oregon Medical Research Center, Portland, Oregon, United States, 3University of Southern California Keck School of Medicine, Los Angeles, California, United States, 4Icahn School of Medicine at Mount Sinai, New York, New York, United States, 5Graduate School of Medicine, Kyoto University, Kyoto, Japan, 6Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan, 7Whittington Health NHS Trust, London, United Kingdom, 8LEO Pharma A/S, Ballerup, Hovedstaden, Denmark, 9LEO Pharma Inc, Madison, New Jersey, United States
17.00-17.10 ORAL 180 [POSTER 1301 ]
Polyamines: Novel regulators of human epidermal pigmentation
A. Sridharan1, Z. Lim1, K. Igarashi4, A. N. Tan3, S. T. Thng2, L. A. Vardy1
1Agency for Science Technology and Research, Singapore, Singapore, 2National Skin Centre, Singapore, Singapore, 3Nanyang Technological University, Singapore, Singapore, 4Chiba Daigaku Daigakuin Igaku Kenkyuin Igakubu, Chiba, Japan
17.10-17.20 ORAL 181 [POSTER 1305 ]
Involucrin/ck1e/vitamin D receptor regulatory axis underlies evolution of human epidermis out of Africa
A. R. Hicks1, 2, A. D. Schmidt3, M. Mathyer3, C. de Guzman Strong1, 2, 3
1Dermatology, Henry Ford Health System, Detroit, Michigan, United States, 2Medicine, Michigan State University College of Human Medicine, East Lansing, Michigan, United States, 3Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri, United States
17.20-17.30 ORAL 182 [POSTER 1318 ]
Racial differences in the skin microbiome of cutaneous T cell lymphoma patients
L. Ayanruoh1, M. J. Hooper1, T. Griffin1, G. Enriquez2, J. Choi1, J. Guitart1, M. Burns2, X. Zhou1
1Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 2Biology, Loyola University Chicago, Chicago, Illinois, United States
17.30-17.40 ORAL 183 [POSTER 1320 ]
Keloid transcriptome analysis: ZNF469 more than meets the eye
S. Hamzehlou1, C. Xing2, D. Glass1, 2
1Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
17.40-17.50 ORAL 184 [POSTER 1294 ]
Proteomic profiling of CCCA reveals unique inflammatory and metabolic protein signature
A. Gadre1, T. Dyson2, C. Aguh1
1Dept of Dermatology, Johns Hopkins Medicine, Baltimore, Maryland, United States, 2Eastern Virginia Medical School, Norfolk, Virginia, United States
17.50-18.00 ORAL 185 [POSTER 1312 ]
Heterogeneities in proteomic profiles among African American and East African patients with atopic dermatitis
D. Liu1, E. Del Duca1, Y. Renert-Yuval2, C. Lang3, H. Kaderbhai4, G. Semango4, M. Brüggen3, J. Krueger2, J. Masenga4, E. Guttman-Yassky1
1Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States, 2Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York, United States, 3Dermatology, UniversitatsSpital Zurich, Zurich, Switzerland, 4Dermatology, Regional Dermatology Training Centre, Moshi, Tanzania, United Republic of
Concurrent talks are 8 minutes plus 2 minutes discussion
15.30-15.40 ORAL 186 [POSTER 1390 ]
Active hair growth is fuelled by conveyor-belt like differentiation of germinative layer cells
K. Annusver1, D. Pereira2, D. Fernandex1, B. Robert3, J. Nicolas3, M. Kasper1, I. Sequeira2
1Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden, 2Queen Mary University of London Barts and The London School of Medicine and Dentistry, London, United Kingdom, 3Institut Pasteur, Paris, Île-de-France, France
15.40-15.50 ORAL 187 [POSTER 1322 ]
A non-cell autonomous dermal hedgehog signaling mechanism for follicular neoplasia and induction.
S. Li1, 2, A. Shah2, E. Sanchez-Ortiz2, N. Liu2, E. Olson2
1Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 2Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
15.50-16.00 ORAL 188 [POSTER 1401 ]
ΔNp63 regulates homeostasis, stemness, and suppression of inflammation in the adult epidermis
C. Eyermann1, X. Chen1, O. Somuncu1, A. Joukov2, J. Chen1, E. Alexandrova1
1Stony Brook University, Stony Brook, New York, United States, 2Ward Melville High School, East Setauket, New York, United States
16.00-16.10 ORAL 189 [POSTER 1439 ]
Development of a complex skin organ in human induced pluripotent stem cell-derived organoids
A. Shafiee1, 2, 3, J. Sun1, I. Ahmed1, J. Brown2, 3, K. Khosrotehrani1
1The University of Queensland, Brisbane, Queensland, Australia, 2Herston Biofabrication Institute, Metro North Hospital and Health Service, Brisbane, Queensland, Australia, 3Royal Brisbane and Women’s Hospital, Metro North Hospital and Health Service, Brisbane, Queensland, Australia
16.10-16.20 ORAL 190 [POSTER 1426 ]
Deletion of hoxc13 in frogs reveals key steps in the molecular evolution of cornified skin appendages
A. P. Sachslehner1, M. Carron2, 3, S. Demuynck2, E. De Baere3, K. Vleminckx2, L. Eckhart1
1Department of Dermatology, Medical University of Vienna, Vienna, Austria, 2Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium, 3Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
16.20-16.30 ORAL 191 [POSTER 1397 ]
LSD1 is critical for epidermal development and skin barrier formation
N. Kuprasertkul, S. Egolf, C. Magahis, C. D’souza, J. Zou, D. Brennan-Crispi, B. C. Capell
University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
16.30-16.40 ORAL 192 [POSTER 1438 ]
KLF4 maintains hair follicle stem cell quiescence
M. Xu1, D. Moran2, K. M. Szigety2, X. Zhu1, S. Millar1
1Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai Black Family Stem Cell Institute, New York, New York, United States, 2Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
16.40-16.50 ORAL 193 [POSTER 1418 ]
Characterization of ectomesenchyme as an origin of epidermal stem cells
A. Miura1, Y. Kobayashi1, Y. Hirose1, A. Yamanishi1, Y. Ouchi2, R. Yamamoto2, T. Kitayama2, E. Takaki2, T. Shimbo2, K. Tamai1
1Stem Cell Therapy Science, Osaka University Graduate School of Medicine, Suita-city, Osaka, Japan, 2StemRIM Institute of Regeneration-Inducing Medicine, Osaka University, Suita-city, Osaka, Japan
16.50-17.00 ORAL 194 [POSTER 1376 ]
A multi-scale spatial atlas of human skin links cancer cell states to site of origin
C. Ganier1, B. Du-Harpur1, G. Herrera-Oropeza8, P. Mazin2, A. Predeus2, J. Gabriel1, N. Harun1, M. Blakeley1, J. Darrigrand1, A. Haiser1, S. Wyles3, T. J. Shaw4, S. Teichmann2, M. Haniffa2, 5, F. M. Watt1, 6, M. Lynch1, 7
1Centre for Gene Therapy and Regenerative Medecine, Guy’s Hospital, King’s College London Faculty of Life Sciences and Medicine, London, United Kingdom, 2Wellcome Sanger Institute, Hinxton, Cambridgeshire, United Kingdom, 3Department of Dermatology, Mayo Clinic Minnesota, Rochester, Minnesota, United States, 4Centre for Inflammation Biology & Cancer Immunology, King’s College London School of Medical Education, London, United Kingdom, 5Department of Dermatology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom, 6Gesellschaft zur Forderung der Lebenswissenschaften Heidelberg GmbH, Heidelberg, Baden-Württemberg, Germany, 7St John’s Institute of Dermatology, King’s College London Faculty of Life Sciences and Medicine, London, United Kingdom, 8King’s College London Institute of Psychiatry Psychology and Neuroscience, London, United Kingdom
17.00-17.10 ORAL 195 [POSTER 1352 ]
Ectopic fibroblasts to modify skin identity
S. S. Lee1, P. Derr2, E. Dare1, E. Sweren1, K. Derr2, B. Hardesty1, C. Wang1, A. Willis1, J. Chen3, J. Vuillier1, J. Du1, M. Daskam1, J. Wool1, A. Ruci1, V. . Wang1, C. Lee1, S. Iyengar1, D. Cho1, E. Martinez-Pena1, S. Lee1, X. He1, S. Kim1, Y. Chen3, S. Kang1, L. A. Garza1
1Dermatology, Johns Hopkins Medicine, Baltimore, Maryland, United States, 2National Center for Advancing Translational Sciences, Rockville, Maryland, United States, 3Johns Hopkins University Whiting School of Engineering, Baltimore, Maryland, United States
17.10-17.20 ORAL 196 [POSTER 1381 ]
Investigating the role of Mef2c in hair follicle cycling
T. Tien1, 3, N. Pantelireis1, 2, C. Higgins2, C. Clavel1, 3
1A*STAR Skin Research Labs, Agency for Science Technology and Research, Singapore, Singapore, 2Imperial College London Department of Bioengineering, London, London, United Kingdom, 3Lee Kong Chian School of Medicine, Singapore, Singapore
17.20-17.30 ORAL 197 [POSTER 1443 ]
Skin regional specificity and the regulation of HoxC gene cluster
S. Hsieh Li1, 2, Y. Liang1, R. Widelitz1, L. Andersson3, P. Wu1, C. Chuong1
1Pathology, University of Southern California, Los Angeles, California, United States, 2Biochemistry, National Defense Medical Center, Taipei, Taiwan, 3Medical Biochemistry and Microbiology, Uppsala universitet Medicinska fakulteten, Uppsala, Sweden
17.30-17.40 ORAL 198 [POSTER 1360 ]
Fate tracing of DNA-damaged hair follicle stem cells and their seno-differentiation clearance out of the niche
M. Miranda, H. Matsumura, K. Asakawa, T. Kato, Y. Muroyama, M. Higa, L. Tan, Y. Kawamura, E. K. Nishimura
Division of Aging and Regeneration, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
17.40-17.50 ORAL 199 [POSTER 1383 ]
Dermal adipogenesis is regulated by an interplay between the WNT-β-catenin and IL1 signaling pathways during skin development and regeneration
X. Zhang3, L. Sun3, S. Wu3, W. Liu3, Y. Liu3, F. Li1, Q. Yao3, J. Li3, J. Huang2, C. Ji2, R. L. Gallo1, L. Zhang3
1Department of Dermatology, University of California San Diego, La Jolla, California, United States, 2Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, 3State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China
17.50-18.00 ORAL 200 [POSTER 1356 ]
Wound memory predisposes to tumorigenesis
M. Watanabe1, 2, 5, C. Levralevron1, 2, V. Proserpio1, 2, 3, G. Piacenti1, 2, A. Lauria1, 2, 3, S. Kaltenbach4, A. Tamburrini1, 2, 3, K. Natsuga5, T. Hagai4, S. Oliviero1, 2, 3, G. Donati1, 2
1Life Sciences and Systems Biology, Universita degli Studi di Torino, Torino, Piemonte, Italy, 2Molecular Biotechnology Center, Universita degli Studi di Torino, Torino, Piemonte, Italy, 3Italian Institute for Genomic Medicine, Torino, Piemonte, Italy, 4George S Wise Faculty of Life Sciences, Tel Aviv University The Shmunis School of Biomedicine and Cancer Research, Tel Aviv, Israel, 5Dermatology, Hokkaido Daigaku Daigakuin Igaku Kenkyuin, Sapporo, Hokkaido, Japan