Plenary talks are 10 minutes plus 2 minutes discussion
08.10 AM-08.22 ORAL 201 [POSTER 1405 ]
Cellular and molecular characterization of sebaceous gland self-renewal and regeneration following complete genetic ablation
N. A. Veniaminova1, Y. Jia2, A. Hartigan1, T. Huyge1, S. Tsai1, M. A. Grachtchouk1, S. Nakagawa3, A. Dlugosz1, 4, S. Atwood2, S. Wong1, 4
1Department of Dermatology, University of Michigan, Ann Arbor, Michigan, United States, 2Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States, 3Department of Pathology, University of Michigan, Ann Arbor, Michigan, United States, 4Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States
08.22 AM-08.34 ORAL 202 [POSTER 469 ]
Evidence of a causal relationship between stroke and psoriasis
R. Ramessur, J. Saklatvala, J. Barker, N. Dand, M. Simpson, C. Smith
King’s College London, London, United Kingdom
08.34 AM-08.46 ORAL 203 [POSTER 668]
Prevention of cardiovascular disease and mortality in patients with psoriasis or psoriatic arthritis (CP3) study: Preliminary results
A. Neopaney5, S. Wang5, D. B. Shin5, R. Fitzsimmons5, S. Baez5, A. Armstrong1, J. Barbieri2, R. Beidas4, M. Garshick3, N. Mehta6, A. Ogdie5, J. Gelfand5
1University of Southern California, Los Angeles, California, United States, 2Harvard University, Cambridge, Massachusetts, United States, 3NYU Langone Health, New York, New York, United States, 4Northwestern University, Chicago, Illinois, United States, 5University of Pennsylvania, Philadelphia, Pennsylvania, United States, 6George Washington University, Washington, District of Columbia, United States
08.46 AM-08.58 ORAL 204 [POSTER 851 ]
RNA therapy for congenital melanocytic naevi
D. Bryant1, 3, R. Maeshima3, W. Baird3, A. Sauvadet1, 3, C. Demetriou3, D. Zecchin1, 3, S. Barberan-Martin1, 3, A. Pittman5, S. Polubothu3, 2, L. Larue4, S. L. Hart3, V. A. Kinsler1, 2, 3
1Mosaicism and Precision Medicine Lab, Francis Crick Institute, London, United Kingdom, 2Great Ormond Street Hospital, London, United Kingdom, 3UCL Institute of Child Health, London, United Kingdom, 4Institut Curie, Orsay, France, 5St George’s University of London, London, United Kingdom
08.58-09.10 ORAL 205 [POSTER 1208 ]
Lactate and its induced EGR1 are novel key factors that determines the inflamed or non-inflamed tumor status
H. Kanemaru1, 2, Y. Mizukami1, A. Kaneko1, T. Kimura1, H. Kuriyama1, I. Kajihara1, S. Fukushima1
1Department of Dermatology and Plastic Surgery, Kumamoto University, Kumamoto, Japan, 2Department of Life Sciences, Imperial College London, London, United Kingdom
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 206 [POSTER 355 ]
Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch
S. Takahashi1, S. Ochiai1, T. Okada1, 2
1Rikagaku Kenkyujo Yokohama Campus, Yokohama, Kanagawa, Japan, 2Yokohama Shiritsu Daigaku, Yokohama, Kanagawa, Japan
13.25-13.35 ORAL 207 [POSTER 319 ]
Spatial transcriptomics and single-cell transcriptomics elucidates the intricate inflammatory cellular network in atopic dermatitis
Y. Mitamura1, M. Reiger2, J. Kim1, Y. Xiao1, D. Zhakparov1, B. Rückert1, P. Brunner3, D. Roqueiro4, C. Traidl-Hoffmann2, C. Akdis1
1Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung, Davos, Switzerland, 2Department of Environmental Medicine, Faculty of Medicine, Universitat Augsburg, Augsburg, Bayern, Germany, 3Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States, 4Department of Biosystems Science and Engineering, ETH-Bereich Hochschulen, Zurich, Zürich, Switzerland
13.35-13.45 ORAL 208 [POSTER 349 ]
Propionate alleviates itch in atopic dermatitis by modulating sensory TRP channels of dorsal root ganglion
Y. Xu1, X. Yao2, W. Li1
1Department of Dermatology, Huashan Hospital Fudan University, Shanghai, China, 2Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China
13.45-13.55 ORAL 209 [POSTER 338 ]
Extracellular matrix (ECM) remodeling in atopic dermatitis (AD) as a putative contributor to the atopic march
D. S. Wörz1, P. Graff3, T. Blimkie2, P. Panwar5, D. Brömme5, R. E. Hancock2, S. Hedtrich1, 4
1Berlin Institute of Health at Charite, Berlin, Germany, 2The University of British Columbia Centre for Microbial Diseases and Immunity Research, Vancouver, British Columbia, Canada, 3Freie Universitat Berlin Institut fur Pharmazie, Berlin, Germany, 4The University of British Columbia Faculty of Pharmaceutical Sciences, Vancouver, British Columbia, Canada, 5The University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada
13.55-14.05 ORAL 210 [POSTER 363 ]
Elevated expression of CCN1 in dermal fibroblasts causes accelerated dermal aging and promotes keratinocyte carcinogenesis
T. Quan, A. Kim, C. Guo, Y. Xiang, Z. Qin, Y. Liu, Y. Yan, A. Ermilov, J. J. Voorhees, A. Dlugosz, G. J. Fisher
Dermatology, University of Michigan, Ann Arbor, Michigan, United States
14.05-14.15 ORAL 211 [POSTER 351 ]
Single-cell analysis of immune system interactions in the basal cell carcinoma tumor microenvironment
Q. N. Wong, S. Atwood
Developmental and Cell Biology, University of California Irvine, Irvine, California, United States
14.15-14.25 ORAL 212 [POSTER 323 ]
Transcriptomic analysis indicates that loss of epidermal Pparg promotes TLR4 signaling and significant overlap with the NMSC transcriptome
R. L. Konger1, X. Xuei2, H. Gao2
1Pathology, Indiana University School of Medicine, Indianapolis, Indiana, United States, 2Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States
14.25-14.35 ORAL 213 [POSTER 359 ]
Pansclerotic morphea is characterized by type II IFN responses priming T cell – cDC2b – fibroblast crosstalk to promote fibrosis
E. Xing, F. Ma, A. Billi, M. Gharaee-Kermani, J. M. Kahlenberg, R. Wasikowski, L. Tsoi, D. Khanna, J. Gudjonsson
University of Michigan, Ann Arbor, Michigan, United States
14.35-14.45 ORAL 214 [POSTER 336 ]
NET-associated DLL4 activates notch- γ secretase signaling in macrophages and fibroblasts and promotes pro-fibrotic responses in hidradenitis suppurativa
C. Carmona-Rivera1, C. B. Oliveira1, J. Tena-Romo1, E. Patino-Martinez1, A. Woo1, A. Byrd2, G. Okoye2, M. Kaplan1
1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, United States, 2Dermatology, Howard University College of Medicine, Washington, District of Columbia, United States
14.45-14.55 ORAL 215 [POSTER 347 ]
A machine learning analysis enables demonstration that fibroblasts mediate neutrophil recruitment during type 17 skin inflammation
K. Cavagnero, T. Dokoshi, A. O’Neill, T. Nakatsuji, F. Li, R. L. Gallo
Dermatology, University of California San Diego, La Jolla, California, United States
14.55-15.05 ORAL 216 [POSTER 327 ]
The early reactivation of resident CD8+ memory t cells depends on cross-presentation of antigen by langerhans cells in the epidermis.
N. Kamenjarin1, 2, K. Hodapp1, 2, F. Melchior1, 2, G. Harms2, 3, V. Raker4, C. Becker4, A. Brand2, 5, B. Clausen2, 5, H. Probst1, 2
1Institute of Immunology, Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, Mainz, Rheinland-Pfalz, Germany, 2Research Center for Immunotherapy, Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, Mainz, Rheinland-Pfalz, Germany, 3Cell Biology Unit, Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, Mainz, Rheinland-Pfalz, Germany, 4Department of Dermatology, Westfalische Wilhelms-Universitat Munster, Münster, Nordrhein-Westfalen, Germany, 5Institute for Molecular Medicine, Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
15.05-15.15 ORAL 217 [POSTER 361]
p120-catenin regulates epidermal inflammation in a cadherin-dependent manner
T. Seo, H. Xu, M. Sennett, S. L. Schell, A. M. Nelson, A. P. Kowalczyk
Dermatology, Penn State College of Medicine, Hershey, Pennsylvania, United States
15.15-15.25 ORAL 218 [POSTER 373 ]
Identification of immune cell pathways in acne vs. rosacea by single-cell RNA sequencing and single-cell spatial imaging
T. H. Do1, 2, J. Perrie2, M. Pellegrini2, J. Gudjonsson3, F. Ma3, R. L. Modlin2
1Stony Brook Southampton Hospital, Southampton, New York, United States, 2University of California Los Angeles, Los Angeles, California, United States, 3University of Michigan, Ann Arbor, Michigan, United States
15.25-15.35 ORAL 219 [POSTER 350 ]
Increased LL37 in patients with psoriasis and rosacea promotes the uptake of low-density lipoprotein and development of atherosclerosis
Y. Nakamura1, N. Kulkarni1, T. Dokoshi1, E. W. Luo2, H. Alimohamadi2, G. C. Wong2, R. L. Gallo1
1Dermatology, University of California San Diego, La Jolla, California, United States, 2Bioengineering, University of California Los Angeles, Los Angeles, California, United States
15.35-15.45 ORAL 220 [POSTER 365 ]
Axon growth inhibitory molecule nogo regulates epidermal innervation by sensory neurons
A. Matsuyama, T. Okada
Center for Integrative Medical Sciences, Rikagaku Kenkyujo Yokohama Campus, Yokohama, Kanagawa, Japan
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 221 [POSTER 690 ]
Trends in topical steroids spending and potential savings: An analysis of United States medicare part D from 2011 to 2020
S. Ly1, 2, P. Manjaly1, K. Kamal1, A. Mostaghimi1
1Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, United States, 2University of Arkansas for Medical Sciences College of Medicine, Little Rock, Arkansas, United States
13.25-13.35 ORAL 222 [POSTER 683 ]
Loneliness, stress, and discrimination in patients with and without acne: A cross-sectional study
W. Perry1, 2, S. Tushe2, H. Yeung2
1Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, United States, 2Dermatology, Emory University School of Medicine, Atlanta, Georgia, United States
13.35-13.45 ORAL 223 [POSTER 586 ]
Increase in CD8+ effector memory cells re-expressing CD45RA (TEMRA) reflects disease activity and enables early prediction of therapeutic outcome in rapidly progressive alopecia areata
R. Takahashi1, M. Kinoshita-Ise2, Y. Sato2, M. Kimishima2, M. Ohyama1, 2
1Flow Cytometry Core Facility, Kyorin University Graduate School of Medicine, Mitaka, TOKYO, Japan, 2Department of Dermatology, Kyorin University Faculty of Medicine, Mitaka, TOKYO, Japan
13.45-13.55 ORAL 224 [POSTER 689 ]
Tiktok and dermal fillers: A cross-sectional study on dermal filler-related content quality
H. de Baun1, P. E. Cerri-Droz1, S. Khan2, B. Rao2
1Stony Brook University Renaissance School of Medicine, Stony Brook, New York, United States, 2Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, United States
13.55-14.05 ORAL 225 [POSTER 646 ]
IFN-α therapy of peritoneal carcinosis induces senescence in metastatic melanoma cells
E. Brenner, T. Wieder, H. Braumüller, C. Boß, C. Schulz, S. Kayser, M. Röcken
Eberhard-Karls-Universitat Tubingen Medizinische Fakultat, Tubingen, Baden-Württemberg, Germany
14.05-14.15 ORAL 226 [POSTER 597 ]
Interim results of a phase I/II, closed label, randomized pilot study for the safety and efficacy of TolaSure gel, 5% w/w targeting aggregated mutant keratin in severe epidermolysis bullosa simplex (TAMES)
A. N. Johnson1, K. McGuire2, A. McCormick2, K. E. Rieger1, L. Broadwater2, S. Jain1, L. Perrone1, J. M. Teng1, J. Y. Tang1, A. S. Chiou1
1Dermatology, Stanford University School of Medicine, Stanford, California, United States, 2BioMendics, LLC, Rootstown, Ohio, United States
14.15-14.25 ORAL 227 [POSTER 626]
Clinical trial of bacteriotherapy as antibiotic-sparing therapy for acne vulgaris
E. S. Burger, S. Brinton, A. O’Neill, T. Nakatsuji, F. Shafiq, O. C. Osuoji, T. Hata, R. L. Gallo
Dermatology, University of California San Diego, La Jolla, California, United States
14.25-14.35 ORAL 228 [POSTER 621 ]
Topical simvastatin for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled investigator-initiated trial
Z. Chen, Y. Liu, H. Yu, H. Chen, Y. Yang
Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China
14.35-14.45 ORAL 229 [POSTER 693 ]
Social media as an educational platform for seborrheic dermatitis
S. Fakhraie, R. Chovatiya
Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
14.45-14.55 ORAL 230 [POSTER 691 ]
Visualization of Covid-19 pandemic influence on healthcare routines in dermatology using electronic health record data
J. Ryan Wolf1, L. Zhang2, Y. Xie3, A. Pentland1, B. T. Pentland2
1Dermatology, University of Rochester Medical Center, Rochester, New York, United States, 2College of Business, Michigan State University, East Lansing, Michigan, United States, 3Public Health Sciences, University of Rochester Medical Center, Rochester, New York, United States
14.55-15.05 ORAL 231 [POSTER 692]
Impact of education on illness perception in patients with cutaneous T-cell lymphoma
A. Munjal, O. Pierog, D. Weiner, S. Talluru, A. Burns, S. Rozati
Dermatology, Johns Hopkins University, Baltimore, Maryland, United States
15.05-15.15 ORAL 232 [POSTER 587 ]
Higher IL-10+ T cell and treg cell counts in psoriatic skin are associated with super-response to guselkumab: Data from the phase 3 guide trial
J. Angsana6, K. Kohler6, J. Sendecki6, M. W. Leung6, S. Tabori7, N. Krüger7, S. Wegner7, Y. Personke7, R. Sabat2, K. Wolk2, A. Pinter1, P. Weisenseel3, K. Asadullah2, 8, K. Schäkel4, K. Eyerich5
1Uni. Hosp. Frankfurt am Main, Frankfurt am Main, Germany, 2Charité–Universitätsmedizin Berlin, Berlin, Germany, 3Dermatologikum Hamburg, Hamburg, Germany, 4Heidelberg Uni. Hosp., Heidelberg, Germany, 5Med. Center, Uni. of Freiburg, Freiburg, Germany, 6Janssen R&D LLC, San Diego, California, United States, 7Janssen-Cilag GmbH, Neuss, Germany, 8Dermatological practice, Potsdam, Germany
15.15-15.25 ORAL 233 [POSTER 590 ]
Litifilimab modulates Type 1 interferon (IFN) biomarkers in patients with cutaneous lupus erythematosus (CLE): Result of the LILAC Part B Phase 2 study
V. P. Werth1, R. A. Furie2, E. Milliman3, K. Ferber3, F. Casey3, R. Brown3, D. Raitcheva3, J. Zoghbi3, D. Graham3, G. Kong3, Y. Lahoud3, N. Franchimont3, C. Barbey4
1University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2Northwell Health, Great Neck, New York, United States, 3Biogen, Cambridge, Massachusetts, United States, 4Biogen, Baar, Switzerland
15.25-15.35 ORAL 234 [POSTER 669 ]
Examining disparities in melanoma detection: A geospatial analysis of access-to-care
M. M. Tran, T. Vance, S. Yumeen, L. Orsillo, F. N. Mirza, A. Robbins, A. Mehta, O. Wisco
Dermatology, Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
15.35-15.45 ORAL 235 [POSTER 624 ]
Clinical and immune analysis of mesenchymal stromal cells (MSCs) for multiple biologic-resistant psoriasis
S. M. Lwin, S. Solanky, I. Tosi, H. Dawe, J. A. McGrath, C. Giacomini, P. di Meglio, F. Dazzi, C. E. Griffiths
King’s College London, London, United Kingdom
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 236 [POSTER 766 ]
H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes
E. Rozhkova1, G. Chen1, L. Yang2, N. Lau3, V. A. Botchkarev1, A. Sharov1
1Dermatology, Boston University, Boston, Massachusetts, United States, 2University of Washington, Seattle, Washington, United States, 3Biochemistry, Boston University, Boston, Massachusetts, United States
13.25-13.35 ORAL 237 [POSTER 737 ]
The role of bisphenol A in atopic dermatitis
D. c. Minzaghi1, V. Cerkvenik Flajs2, S. Dubrac1
1Department of Dermatology, Venereology and Allergology, innsbruck medical university, Innsbruck, Austria, 2Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Slovenia, Ljubljana, Slovenia
13.35-13.45 ORAL 238 [POSTER 775 ]
A secretome CRISPR screen identifies SFRP1 and other extracellular proteins regulating epidermal homeostasis
B. Cheng1, T. Bencomo2, C. S. Lee2, B. Sun1
1Dermatology, University of California San Diego, La Jolla, California, United States, 2Dermatology, Stanford University School of Medicine, Stanford, California, United States
13.45-13.55 ORAL 239 [POSTER 745 ]
Gasdermin a guards epidermal differentiation and cornification in skin barrier repair: Its role in atopic dermatitis pathogenesis
L. Huang1, S. Li1, S. Lin1, C. Kao5, C. Hong3, 4, C. Lee2, L. Yang1, 6
1Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, 2Chang Gung University College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 3Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 4Department of Dermatology, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan, 5Center of General Education, Chang Gung University, Taoyuan, Taiwan, 6Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
13.55-14.05 ORAL 240 [POSTER 738 ]
Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis
F. Chin1, F. Qin2
1University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States, 2Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York, United States
14.05-14.15 ORAL 241 [POSTER 750 ]
Epidermal expression of Hes1 controls immune response
M. Wakatake, M. Moriyama, S. Goto, Y. Miyake, H. Moriyama
Kinki Daigaku, Higashi-Osaka, Japan
14.15-14.25 ORAL 242 [POSTER 783]
Epidermal-specific ablation of CD271 is linked to altered proliferation and differentiation of keratinocytes during postnatal mouse skin development
M. Quadri1, C. Pellegrini2, M. Mastrangelo2, M. Fargnoli2, C. Vaschieri1, M. Canossa3, M. I. Morasso4, R. Lotti1, C. Pincelli1, A. Marconi1, E. Palazzo1
1DermoLab, University of Modena and Reggio Emilia, Modena, Italy, 2University of L’Aquila, L’Aquila, Italy, 3CIBIO, University of Trento, Trento, Italy, 4Lab Skin Biology, National Institutes of Health, Bethesda, Maryland, United States
14.25-14.35 ORAL 243 [POSTER 772 ]
Structure of a novel endoplasmic reticulum-desmosome complex
N. Bharathan1, W. Giang1, J. Aaron3, S. Khuon3, T. Chew3, A. Weigel3, S. Saalfeld3, W. Vogl2, S. N. Stahley1, A. P. Kowalczyk1
1Dermatology, Penn State College of Medicine, Hershey, Pennsylvania, United States, 2Cellular & Physiological Sciences, The University of British Columbia, Vancouver, British Columbia, Canada, 3Howard Hughes Medical Institute Janelia Farm Research Campus, Ashburn, Virginia, United States
14.35-14.45 ORAL 244 [POSTER 697 ]
The overexpression of sphingomyelin deacylase in murine epidermis elicits a ceramide deficiency and provokes atopic dermatitis-like skin eruptions
M. Kimura1, M. Takada2, M. Komine1, H. Tsuda3, M. Ohtsuki1, G. Imokawa2
1Dermatology, Jichi Ika Daigaku, Shimotsuke, Tochigi, Japan, 2Utsunomiya Daigaku, Utsunomiya, Tochigi, Japan, 3Division of Human Genetics Center for Molecular Medicine, Jichi Ika Daigaku, Shimotsuke, Tochigi, Japan
14.45-14.55 ORAL 245 [POSTER 723]
Common and different roles of dermokine in skin diseases based on mouse genetic background
K. Kawate, T. Shimizu, T. Chino, N. Oyama, M. Hasegawa
Department of Dermatology, Fukui Daigaku Igakubu, Yoshida-gun, Fukui, Japan
14.55-15.05 ORAL 246 [POSTER 751 ]
Regulation of epidermal homeostasis by centrosomal protein Cep43
C. C. Yokoyama1, M. Colonna2
1Internal Medicine, Division of Dermatology, Washington University in St Louis, St Louis, Missouri, United States, 2Pathology & Immunology, Washington University in St Louis, St Louis, Missouri, United States
15.05-15.15 ORAL 247 [POSTER 774 ]
Receptor tyrosine kinase EPHA2 is required for epidermal barrier homeostasis
B. Shi, T. Selph, K. Russell, T. Mahi, E. Khan, I. Martinez, G. Sinchi-Paucar, M. Liu, H. Peng, B. E. Perez White
Northwestern University, Chicago, Illinois, United States
15.15-15.25 ORAL 248 [POSTER 749 ]
TNF-α promotes psoriasis-related keratinocytes dedifferentiation through dual regulation of YAP and NOTCH1 signaling
Z. Yu1, Y. Shi2
1Shanghai Tenth People’s Hospital, Shanghai, China, 2Shanghai Skin Diseases Hospital, Shanghai, China
15.25-15.35 ORAL 249 [POSTER 796 ]
Actin dependent regulation of epidermal differentiation and barrier formation
M. Ruebsam1, A. Bhosale1, F. Tellkamp2, T. Matsui3, M. Amagai4, M. Krüger2, C. M. Niessen1
1Department Cell Biology of the Skin & CECAD, Universitat zu Koln, Köln, Nordrhein-Westfalen, Germany, 2Institute for Genetics, Universitat zu Koln, Köln, Nordrhein-Westfalen, Germany, 3School of Bioscience and Biotechnology, Tokyo Koka Daigaku, Hachioji, Tokyo, Japan, 4Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
15.35-15.45 ORAL 250 [POSTER 797 ]
Crosstalk between adherens junctions and desmosomes and associated cytoskeletons controls epidermal adhesion dynamics and mechanical resilience
H. Zhang1, M. Ruebsam1, R. Püllen2, K. Green3, R. Merkel2, B. Hoffmann2, S. Wickström4, 5, C. M. Niessen1
1Cell Biology of the Skin and CECAD, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, 2Institute of Biological Information Processing, IBI-2: Mechanobiology, Forschungszentrum Julich GmbH, Julich, Nordrhein-Westfalen, Germany, 3Departments of Pathology and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 4Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany, 5Stem Cells and Metabolism Research Program, Helsingin yliopisto Laaketieteellinen tiedekunta, Helsinki, Uusimaa, Finland
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 251 [POSTER 960 ]
A metabolite produced by skin commensal bacteria enhances epithelial integrity in human keratinocyte
F. A. Aldehalan, A. J. Mcbain, C. O’Neill
The University of Manchester Faculty of Biology Medicine and Health, Manchester, United Kingdom
13.25-13.35 ORAL 252 [POSTER 956 ]
Epidermal keratinocyte-specific STAT3 deficiency aggravated atopic dermatitis-like skin inflammation in mice through TSLP upregulation
Z. Wang, X. Man
Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
13.35-13.45 ORAL 253 [POSTER 966 ]
Cx26 mutation in keratinocytes is responsible for susceptibility to candida albicans in the mouse model of keratitis-ichthyosis-deafness syndrome
A. Mostafa1, T. Murata2, H. Doi1, G. Egawa1, K. Kabashima1
1Dermatology, Graduate School of Medicine Kyoto University, Kyoto, Japan, 2Dermatology, Hyogo Medical University, Nishinomiya, Japan
13.45-13.55 ORAL 254 [POSTER 983 ]
Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria
K. Robinson1, G. Toh2, K. Tham1, J. E. Common1, F. Zhong2
1ASRL, Singapore, Singapore, 2NTU, Singapore, Singapore
13.55-14.05 ORAL 255 [POSTER 917 ]
Amphiregulin-producing innate lymphoid cells promote barrier response after mechanical damage
T. Kobayashi1, M. Li2, D. Asanuma3, N. Shigeyuki3, K. Hirose3, K. Fujita2, K. Moro1,2
1RIKEN, Yokohama, Japan, 2Osaka University, Osaka, Japan, 3Tokyo University, Tokyo, Japan
14.05-14.15 ORAL 256 [POSTER 939 ]
Acid mantle of the stratum corneum is a shield against bacterial entry into the underlying epidermal layers
Y. Ito1, K. Fukuda2, R. Ozawa1, M. Amagai1, 2
1Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Skin Homeositasis, RIKEN IMS, Yokohama, Japan
14.15-14.25 ORAL 257 [POSTER 945]
Galectin-12 Regulates the Immune Response in Skin Through Sebaceous Glands
F. Lin1, 2, Y. Huang1, 2, Y. Lo4, F. Liu1, 2, 3
1Graduate Institute of Immunology, National Taiwan University, Taipei, Taiwan, 2Institute of Biomedical Sciences Academia Sinica, Taipei, Taiwan, 3University of California Davis Department of Dermatology, Sacramento, California, United States, 4Fu Jen Catholic University, Taipei, Taiwan
14.25-14.35 ORAL 258 [POSTER 923 ]
Microbially-induced transgenerational epigenetic inheritance via the immune system regulates sebum secretion and the chemical barrier
J. Harris1, 2, N. Trigg3, B. Goshu1, C. Conine3, E. Grice2, T. Kambayashi1
1Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States, 2Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States, 3Neonatology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
14.35-14.45 ORAL 259 [POSTER 977 ]
IL-23/IL23R promote macrophage pyroptosis and Th1/Th17 cell differentiation in mycobacterial infection
C. Wang, T. Liu, Z. Wang, Q. Zhao, Z. Mi, H. Liu, F. Zhang
Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Jinan, China
14.45-14.55 ORAL 260 [POSTER 926 ]
The role of HTR2A on langerhans cells in skin inflammation
Y. Tan1, 4, C. Yeh4, S. Su4, C. Lu4, C. Tsai4, H. Weng2, 3, T. Tsai2, Y. Lee1, 4
1National Yang Ming Chiao Tung University – Yangming Campus, Taipei, Taiwan, 2National Taiwan University Hospital, Taipei, Taiwan, 3Taipei Medical University, Taipei, Taiwan, 4Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
14.55-15.05 ORAL 261 [POSTER 981 ]
Adiponectin downregulation in lesional skin contributes to enhanced mTORC1 activation and skin inflammation in rosacea.
J. Suh4, 1, 2, S. Jin4, 1, 2, Y. Lee1, 2, N. Li4, 1, 2, J. Oh1, 2, E. Kim1, 2, S. Kim3, S. Lee4, 1, 2, D. Lee4, 1, 2, S. Cho4, 2, J. Chung4, 1, 2
1Dermatology, Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of), 2Institute of human-environmental interface biology, Seoul, Korea (the Republic of), 3Physiology, Seoul National University College of Medicine, Seoul, Korea (the Republic of), 4Dermatology, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
15.05-15.15 ORAL 262 [POSTER 1050 ]
Neutrophil-intrinsic NLRP12 and caspase-8 signal for inflammasome-mediated host defense against staphylococcus aureus skin infections
M. P. Alphonse1, H. Liu1, D. Dikeman1, R. V. Ortines1, Y. Wang1, Q. Liu1, C. Youn1, G. Wang1, E. A. Cahill1, D. Prifti1, A. Cox2, L. A. Garza1, L. Miller1, 3, N. Archer1
1Dermatology, Johns Hopkins Medicine, Baltimore, Maryland, United States, 2Molecular Microbiology and Immunology, Johns Hopkins Medicine, Baltimore, Maryland, United States, 3Janssen Research and Development LLC, Spring House, Pennsylvania, United States
15.15-15.25 ORAL 263 [POSTER 959 ]
Identification of novel innate immune cells in human epidermis
T. Sato, Y. Ogawa, S. Shimada, T. Kawamura
Department of Dermatology, Yamanashi Daigaku Igakubu Daigakuin Sogo Kenkyubu Igakuiki, Chuo, Yamanashi, Japan
15.25-15.35 ORAL 264 [POSTER 1006]
Single-cell and spatial architecture of human tissue granulomas reveals an aberrant immune-regulatory program underlying sarcoidosis
A. Redl1, 2, T. Krausgruber2, D. Barreca2, C. Lim3, K. Doberer4, L. Unterluggauer1, L. Kleissl5, C. Mayerhofer1, A. Kopf5, T. Weichhart3, C. Bock2, G. Stary1
1Department of Dermatology, Medizinische Universitat Wien, Wien, Austria, 2Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Wien, Austria, 3Institute of Medical Genetics, Medizinische Universitat Wien, Wien, Austria, 4Department of Nephrology, Medizinische Universitat Wien, Wien, Austria, 5Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria
15.35-15.45 ORAL 265 [POSTER 1048 ]
NK cell populations are major contributors to pathogenesis in hidradenitis suppurativa (HS)
C. Raman1, M. Kashyap1, B. Mishra2, J. Deshane3, S. Mukhtar2, C. A. Elmets1, M. Athar1
1Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States, 2Biological Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States, 3Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 266 [POSTER 1224 ]
AhR regulates the efferocytosis and polarization of tumor-associated macrophages through ALKAL1-mediated MerTK activation and promotes melanoma progression
N. Wu, J. Tao
Doctor, Huazhong University of Science and Technology, Wuhan, Hubei, China
13.25-13.35 ORAL 267 [POSTER 1278 ]
Blocking tumor-intrinsic caspase-1 inflammasome sensitizes melanoma response to anti-PD1 therapy by rejuvenating dysfunctional CD8 T cells
P. K. Vaddi1, D. Osborne1, D. Ravindran-Menon1, T. Yamauchi1, Z. Zhai1, M. Fujita1,2, 3
1Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 2Department of Veterans Affairs Medical Center, VA Eastern Colorado Health Care System, Aurora, Colorado, United States, 3Department of Immunology & Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
13.35-13.45 ORAL 268 [POSTER 1216 ]
SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation
X. Yi, W. Guo, H. Wang, Y. Yang, C. Li
Air Force Medical University, Xi’an, Shaanxi, China
13.45-13.55 ORAL 269 [POSTER 1191 ]
Immunotherapy with 4-1BBL-expressing iPSC-derived proliferating myeloid cells amplifies antigen-specific T cell infiltration in advanced melanoma
H. Kuriyama1, T. Kimura1, H. Kanemaru1, A. Miyashita1, T. Inozume2, R. Zhang3, Y. Uemura3, S. Fukushima1
1Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan, 2Department of Dermatology, Chiba University, Chiba, Japan, 3Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba, Japan
13.55-14.05 ORAL 270 [POSTER 1282 ]
Basal cell carcinoma pigmentation is associated with melanocyte proliferation and expression of the melanocyte mitogens endothelin 1 and 2 by tumor cells
E. A. Pedersen1, M. A. Grachtchouk1, M. E. Verhaegen1, L. Syu1, P. W. Harms1, M. Gharaee-Kermani1, F. Ma1, J. Gudjonsson1, M. Ito2, A. Dlugosz1
1University of Michigan, Ann Arbor, Michigan, United States, 2NYU Langone Health, New York, New York, United States
14.05-14.15 ORAL 271 [POSTER 1240 ]
Distinct cAMP signaling microdomains differentially regulate melanosomal pH and pigmentation
D. Zhou1, M. Yusupova1, J. You1, J. Gonzalez-Guzman2, M. Ghanta2, H. Pu4, Z. Abdel-Malek3, J. D’Orazio4, S. Ito5, K. Wakamatsu5, M. Harris2, J. Zippin1, 6, 7
1Dermatology, Weill Cornell Medicine, New York, New York, United States, 2The University of Alabama at Birmingham Department of Cell Developmental and Integrative Biology, Birmingham, Alabama, United States, 3Dermatology, University of Cincinnati, Cincinnati, Ohio, United States, 4Pediatrics, University of Kentucky, Lexington, Kentucky, United States, 5Institute for Melanin Chemistry, Fujita Ika Daigaku, Toyoake, Aichi, Japan, 6Pharmacology, Weill Cornell Medicine, New York, New York, United States, 7Englander Institute of Precision Medicine, Weill Cornell Medicine, New York, New York, United States
14.15-14.25 ORAL 272 [POSTER 1274 ]
Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis
G. Hashemi, L. Sormani Le Bourhis, J. Dight, C. Zhou, E. Roy, K. Khosrotehrani
The University of Queensland, Saint Lucia, Queensland, Australia
14.25-14.35 ORAL 273 [POSTER 1189 ]
PD-1 blockade may promote not only the reactivation of preexisting tumor-specific T cell clones but also the infiltration of new clones
T. Inozume1, 4, 3, J. Nagasaki2, 4, M. Kawazu4, T. Kawamura3, K. Yamashita5, Y. Togashi2, 4
1Dermatology, Chiba University, Chiba, Japan, 2Tumor Microenvironment, Okayama University, Okayama, Japan, 3Dermatology, University of Yamanashi, Kofu, Japan, 4Research Institute, Chiba Cancer Center, Chiba, Japan, 5KOTAI Biotechnologies Inc, Osaka, Japan
14.35-14.45 ORAL 274 [POSTER 1204 ]
Immunogenic cell death by inhibition of glucose-6-phosphate dehydrogenase enhances the efficacy of immunotherapy in malignant melanoma
M. Nakamura, M. Yoshimitsu, T. Magara, S. Kano, H. Kato, A. Morita
Department of Geriatric and Environmental Dermatology, Nagoya Shiritsu Daigaku Daigakuin Igaku Kenkyuka Igakubu, Nagoya, Aichi, Japan
14.45-14.55 ORAL 275 [POSTER 1220 ]
Cytosolic acetyl-CoA drives tumor immune evasion via the epigenetic regulation of PD-L1 in melanoma
H. Wang, W. Guo, X. Yi, Y. Yang, C. Li
Xijing Hospital, Xian, Shaanxi, China
14.55-15.05 ORAL 276 [POSTER 1262 ]
Immuno-apoptotic priming to enhance the efficacy of immunotherapies in melanoma
N. Mukherjee, R. Tobin, E. Katsnelson, M. McCarter, D. Norris, Y. Shellman
University of Colorado, Denver, Colorado, United States
15.05-15.15 ORAL 277 [POSTER 1261 ]
ER stress facilitates anti-cancer immunosurveillance and improves immunotherapy efficacy in melanoma
Y. Yang, S. Guo, H. Wang, C. Li, X. Yi, W. Guo
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
15.15-15.25 ORAL 278 [POSTER 1275 ]
A mutual repression between MITF and neural transcription factors specifies the fate of schwann cell precursors
A. Kawakami1, M. Hejna2, M. Hoang3, K. Kabashima1, J. Song2, D. E. Fisher4
1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Physics, University of Illinois, Urbana, Illinois, United States, 3Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States, 4Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States
15.25-15.35 ORAL 279 [POSTER 1214 ]
Targeting SHOC2 disrupts MEK/ERK signaling and inhibits viability of NRAS-mutant human melanoma cells.
R. A. Francois1, L. Young2, F. McCormick2
1Departments of Dermatology and Pathology, University of California San Francisco, San Francisco, California, United States, 2Helen Diller Family Comprehensive Cancer Center and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States
15.35-15.45 ORAL 280 [POSTER 1181 ]
Delivery of costimulatory molecules and immunostimulatory cytokines leads to targeted and systemic immune activation against melanoma in vivo
K. M. Luly1, J. J. Green1, J. C. Sunshine2, 1, S. Y. Tzeng1
Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
TBA
