Plenary talks are 10 minutes plus 2 minutes discussion
08.10-08.22 ORAL 001 [POSTER 1497]
Type 2-mediated oxidative reprogramming promotes the transition of macrophages into repair mode and is required for wound healing
S. Willenborg1, D. E. Sanin2, E. J. Pearce2, A. Trifunovic3, H. Kashkar3, S. A. Eming1, 3
1Universitat zu Koln, Cologne, Germany, 2Johns Hopkins University, Baltimore, Maryland, United States, 3Exzellenzcluster CECAD in der Universitat zu Koln, Cologne, Germany
08.22 -08.34 ORAL 002 [POSTER 603]
Degradation of aberrant NETs by DNases is a promising therapeutic strategy for SJS/TEN
M. Kinoshita1, Y. Ogawa1, N. Hama2, A. Hasegawa2, S. Shimada1, R. Abe2, T. Kawamura1
1University of Yamanashi, Yamanashi, Japan, 2Niigata University, Niigata, Japan
08.34-08.46 ORAL 003 [POSTER 187]
Recurrent neural networks to predict biologic treatment outcomes in psoriasis
A. Hussain1, C. Atallah1, C. Griffiths2, 3, R. B. Warren2, 3, S. Dlay1, N. Reynolds1, 3
1Newcastle University, Newcastle upon Tyne, United Kingdom, 2Dermatology Centre, The University of Manchester, Manchester, United Kingdom, 3BADBIR study group, Manchester, United Kingdom
08.46-08.58 ORAL 004 [POSTER 180]
Immune-mesenchymal crosstalk contribute to expansion of autoreactive plasma cells in the tertiary lymphoid structures in hidradenitis suppurativa
C. Lu, Wei-Wen Yu1,2, Joy N.P. Barrett1, Jie Tong1, Meng-Ju Lin1, Joseph C. Devlin3,4, Alberto Herrera5, Meaghan Marohn1, Juliana Remark1,4, Pei-Kang Liu6, James G. Krueger7, Kelly V. Ruggles3,8, Sergei B. Koralov5, Ernest S. Chiu1, Catherine P. Lu1,9 *
Plastic Surgery, New York University, New York, New York, United States, 1The Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA, 2Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Institute of Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA, 4Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA, 5Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA, 6Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, 7Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY, USA, 8Division of Translational Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA, 9Department of Cell Biology, New York University Grossman School of Medicine, New York, NY, USA,
* Corresponding author
08.58-09.10 ORAL 005 [POSTER 321]
A human tissue model of Darier disease reveals MEK as a novel therapeutic target downstream of SERCA2 deficiency
S. A. Zaver1, M. Sarkar2, A. Tiwaa1, J. Zou3, S. Egolf3, B. Capell3, J. Gudjonsson2, C. L. Simpson1
1Dermatology, University of Washington School of Medicine, Seattle, Washington, United States, 2Dermatology, University of Michigan, Ann Arbor, Michigan, United States, 3Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Plenary talks are 10 minutes plus 2 minutes discussion
10.20-10.32 ORAL 006 [POSTER 414 ]
Identification of metagenes for prediction of therapeutic efficacy and disease monitoring by decomposing atopic dermatitis skin mRNA-seq data.
A. Fukushima-Nomura1, H. Kawasaki1, 2, K. Tanese1, E. Kawakami3, M. Amagai1
1Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Advanced Data Science Project, RIKEN, Yokohama, Japan
10.32-10.44 ORAL 007 [POSTER 694 ]
Keratinocyte autophagy deficiency aggravates itch-related scratching in atopic dermatitis
G. Peng1, 2, W. Zhao2, K. Okumura2, H. Ogawa2, S. Ikeda1, 2, F. Niyonsaba2, 3
1Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Faculty of International Liberal Arts, Juntendo Daigaku, Tokyo, Japan
10.44 -10.56 ORAL 008 [POSTER 287 ]
Investigating drivers of disease progression in cutaneous squamous cell carcinoma.
M. Treanor-Taylor1, 2, L. Mcgarry1, 2, L. Carlin1, 2, C. Harwood3, I. Leigh3, P. Bailey1, 2, G. Inman1, 2
1Cancer Research UK Beatson Institute, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, Scotland, United Kingdom, 3Queen Mary University of London, London, United Kingdom
10.56-11.08 ORAL 009 [POSTER 866 ]
A single nucleotide activity map of skin disease variants and transcription factors that modulate them
D. Porter, D. L. Reynolds, R. Meyers, W. Miao, A. W. Hong, X. Yang, L. Ducoli, S. Mondal, Z. Siprashvili, I. Elfaki, S. Srinivasan, P. A. Khavari
Dermatology, Stanford University, Stanford, California, United States
11.08-11.20 ORAL 010 [POSTER 1315 ]
Differential response of 3D African American and White Non-Hispanic skin organoids to major pro-inflammatory cytokines
I. Budunova1, D. Trubetskoy1, A. Klopot1, B. Shi1, L. C. Tsoi2, B. E. Perez White1
1Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 2Dermatology, University of Michigan, Ann Arbor, Michigan, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15 -13.25 ORAL 011 [POSTER 120]
Identification of post-translationally modified trichohyalin epitopes responsible for triggering autoimmunity in alopecia areata
S. D. Jadeja, D. Tobin
Charles Institute of Dermatology, University College Dublin, Dublin, Ireland
13.25-13.35 ORAL 012 [POSTER 074]
Newly identification of a CXCR6+ pathogenic skin-resident CD4+ T cell subset in a mouse model of allergic dermatitis that requires CXCL16 for its maintenance
R. Asahina, F. Minami, G. Egawa, S. Nakamizo, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
13.35-13.45 ORAL 013 [POSTER 028]
Psychological stress exacerbates IgE-dependent chronic allergic inflammation by suppressing efferocytosis of M2 macrophages
H. Urakami1, Y. Fujita2, K. Nagao2, K. Miyake4, H. Karasuyama4, S. Miyake3, A. Kamiya2, S. Yoshikawa3, S. Morizane1
1Department of Dermatology, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Okayama, Japan, 2Department of Cellular Physiology, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka, Okayama, Okayama, Japan, 3Department of Immunology, Juntendo Daigaku Igakubu Daigakuin Igaku Kenkyuka, Bunkyo-ku, Tokyo, Japan, 4Inflammation, infection and Immunity Laboratory, Advanced Research Institute, Tokyo Ika Shika Daigaku, Bunkyo-ku, Tokyo, Japan
13.45-13.55 ORAL 014 [POSTER 227]
Immune response and allergenic components of COVID-19 vaccines induced delayed cutaneous reactions
C. Tsai, W. Chung, C. Chen
Drug Hypersensitivity Clinical and Research Center, Department of Dermatology,, Chang Gung Memorial Hospital, Linkou, Taipei, Tucheng and Keelung, Taiwan, Taoyuan, Taiwan
13.55-14.05 ORAL 015 [POSTER 126]
Topical corticosteroids inhibit allergic skin inflammation but are ineffective in impeding the formation and expansion of resident memory T cells
E. Ono1, V. Lenief1, M. Lefevre1, R. Cuzin1, A. Guironnet-Paquet1, A. Mosnier1, A. Nosbaum1, 2, J. Nicolas1, 2, M. Vocanson1
1Centre International de Recherche en Infectiologie, Lyon, Rhône-Alpes, France, 2Hospices Civils de Lyon, Lyon, Auvergne-Rhône-Alpes , France
14.05-14.15 ORAL 016 [POSTER 001]
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis
H. Terui1, K. Yamasaki1, M. Wada-Irimada1, M. Onodera-Amagai1, N. Hatchome1, M. Mizuashi1, R. Yamashita2, T. Kawabe3, N. Ishii3, T. Abe4, 5, 6, Y. Asano1, S. Aiba1
1Department of Dermatology, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan, 2Division of Translational Informatics, Kokuritsu Gan Kenkyu Center Sentan Iryo Kaihatsu Center Kashiwa Campus, Kashiwa, Chiba, Japan, 3Department of Microbiology and Immunology, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan, 4Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan, 5Division of Medical Science, Tohoku Daigaku Daigakuin Ikogaku Kenkyuka, Sendai, Miyagi, Japan, 6Department of Clinical Biology and Hormonal Regulation, Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan
14.15-14.25 ORAL 017 [POSTER 133]
UVB-induced type-I interferon in keratinocytes is associated with expansion of CXCL13+ skin-resident memory T cells in dermatomyositis skin
K. Afshari1, Y. Wang1, N. Haddadi1, S. Sherman1, J. Richmond1, R. Vleugels2, M. Garber1, M. Rashighi1
1University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 2Harvard Medical School, Boston, Massachusetts, United States
14.25-14.35 ORAL 018 [POSTER 140]
Comparative scRNA-Seq profiling of four autoimmune skin diseases points to CXCL13 as a potential player in skin autoimmunity
Y. Wang, K. Afshari, M. Frisoli, N. Haddadi, S. Sherman, J. E. Harris, M. Rashighi, M. Garber
University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States
14.35-14.45 ORAL 019 [POSTER 054]
LPCAT1 aggravates hyperproliferation and inflammatory signals in psoriasis
Y. Huang1, Y. Wang2, Y. Wang3, Y. Zhen1, Q. Sun1
1Department of Dermatology, Qilu Hospital of Shandong University, Jinan, Shandong, China, 2Department of Dermatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China, 3School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
14.45-14.55 ORAL 020 [POSTER 147]
Sebaceous glands actively contribute to distinct immune response patterns in atopic dermatitis and psoriasis
P. Seiringer7, 4, 1, C. Hillig2, T. Biedermann7, C. C. Zouboulis6, M. Menden2, K. Eyerich3, 1, D. Töröcsik5
1Division of Dermatology and Venerology, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 2Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, 3Albert-Ludwigs-Universitat Freiburg, Freiburg, Germany, 4Zentrum Allergie und Umwelt, Munich, Germany, 5Department of Dermatology, Faculty of Medicine, Debreceni Egyetem, Debrecen, Hungary, 6Medizinische Hochschule Brandenburg Theodor Fontane, Neuruppin, Germany, 7Klinikum rechts der Isar, Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
14.55-15.05 ORAL 021 [POSTER 076]
TRPM2-dependent autophagy inhibition promotes CXCL16 secretion by keratinocytes under oxidative stress
P. Kang, Y. Wang, J. Chen, S. Li, X. Yi, C. Li
Department of Dermatology, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, China
15.05-15.15 ORAL 022 [POSTER 172]
Spatiotemporal architecting of skin dendritic cell directed immunity and tolerance
Q. Huang1, A. S. Doane2, Y. Liu2, J. Valencia5, C. Nirschl6, J. Hsu2, A. Savitz1, K. Pradhan1, A. Jaiswal2, G. Song-Zhao6, M. Bale2, R. R. Ricardo-Gonzalez4, R. Locksley4, T. Lawrence7, H. Young5, M. Suarez-Farinas3, O. Elemento2, N. Anandasabapathy1
1Department of Dermatology, Weill Cornell Medicine, New York, New York, United States, 2Weill Cornell Medicine, New York, New York, United States, 3Icahn School of Medicine at Mount Sinai, New York, New York, United States, 4University of California San Francisco, San Francisco, California, United States, 5National Cancer Institute, Bethesda, Maryland, United States, 6Harvard Medical School, Boston, Massachusetts, United States, 7King’s College London, London, United Kingdom
15.15-15.25 ORAL 023 [POSTER 008]
Characterization and pharmacological inhibition of an adult antibody-transfer mouse model of pemphigus vulgaris
S. Emtenani1, M. Hofrichter1, L. Komorowski2, C. Probst2, S. Patzelt1, E. Schmidt1, 3
1Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany, 2Institute of Experimental Immunology, EUROIMMUN AG, Lübeck, Germany, 3Department of Dermatology, University of Lübeck, Lübeck, Germany
15.25-15.35 ORAL 024 [POSTER 012]
CD4+ T cells control immune evasive tumors by reprogramming myeloid cells in an IFN-dependent manner
A. Buzzai1, B. Kruse1, N. Shridhar1, A. Braun1, S. Gellert1, K. Knauth1, J. Peters1, M. Mengoni1, T. van der Sluis1, A. Krone1, D. Yu2, S. Höhn1, Y. Fu1, M. Essand2, R. Geffers3, D. Mougiakakos1, S. Kahlfuß1, H. Kashkar4, E. Gaffal1, W. Kastenmüller5, A. Müller1, T. Tüting1
1Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultat, Magdeburg, Germany, 2Uppsala Universitet, Uppsala, Sweden, 3Helmholtz-Zentrum fur Infektionsforschung GmbH, Braunschweig, Niedersachsen, Germany, 4Institute of Molecular Immunology, Köln, Germany, 5Institute for Systems Immunology, Würzburg, Germany
15.35-15.45 ORAL 025 [POSTER 154]
Nociceptor sensory neurons promote CD8 T cell response to VACV infection
J. Zhang1, T. Pan1, A. Kley1, J. B. Williams1, L. Deng2, I. Chiu2, T. S. Kupper1
1Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, United States, 2Immunology, Harvard Medical School, Boston, Massachusetts, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 026 [POSTER 217]
Time-to-event machine learning prediction of metastatic recurrence of localized melanoma
G. Wan1, 5, B. Leung1, M. DeSimone2, N. Nguyen1, A. Rajeh1, M. Collier1, H. Rashdan1, K. Roster1, M. Asgari1, 5, A. Gusev3, A. Stagner1, C. Lian2, M. Hurlbert4, K. Yu5, H. Tsao1, 5, F. Liu6, P. Sorger5, Y. Semenov1, 5
1Massachusetts General Hospital, Boston, Massachusetts, United States, 2Brigham and Women’s Hospital, Boston, Massachusetts, United States, 3Dana-Farber Cancer Institute, Boston, Massachusetts, United States, 4Melanoma Research Alliance, Washington, District of Columbia, United States, 5Harvard Medical School, Boston, Massachusetts, United States, 6Stevens Institute of Technology, Hoboken, New Jersey, United States
13.25-13.35 ORAL 027 [POSTER 202]
Automated assessment of tumor infiltrating lymphocytes informs mortality in thin melanoma
S. X. Tan1, T. Nwe Aung2, M. Claeson3, C. Zhou1, S. Brown1, B. Acs2, D. Lambie6, P. Baade4, N. Pandeya5, H. Soyer1, B. Smithers6, D. Whiteman5, D. Rimm2, K. Khosrotehrani1
1The University of Queensland, Saint Lucia, Queensland, Australia, 2Yale University, New Haven, Connecticut, United States, 3Sahlgrenska Academy, Gothenburg, Sweden, 4Cancer Council Queensland, Spring Hill, Queensland, Australia, 5QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, 6Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
13.35-13.45 ORAL 028 [POSTER 203]
Automated skin surface phenotype for melanoma risk assessment
B. D. Betz-Stablein1, C. Rutjes1, S. Kahler1, A. Mothershaw1, D. Jayasinghe2, M. Stark1, M. Janda2, H. Soyer1
1Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia, 2Centre for Health Services Research, The University of Queensland, Brisbane, Queensland, Australia
13.45-13.55 ORAL 029 [POSTER 212]
Teledermatology photographs deblurring by deep learning models restores the accuracy of blurry images classification
Z. Jiang3, H. Yeh1, B. Hsu2, S. Chou2, T. Hsu3, V. S. Tseng2, C. Lee3, 4
1Chen Chia-Wei Dermatology, Kaohsiung, Taiwan, 2Computer Science, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, 3Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung, Taiwan, 4Chang Gung University College of Medicine, Taoyuan, Taiwan
13.55-14.05 ORAL 030 [POSTER 207]
Comparison of neural network classification models to determine patch test reactivity
A. Ravishankar, P. L. Bigliardi
Dermatology, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States
14.05-14.15 ORAL 031 [POSTER 210]
A novel system with an end-to-end framework for mouse scratching detection based on deep learning techniques
J. P. Peng1, B. Hsu2, Y. Lin2, V. S. Tseng2, C. Lee3
1Chang Gung Memorial Hospital Kaohsiung Branch Department of Internal Medicine, Kaohsiung, Taiwan, 2National Yang Ming Chiao Tung University Department of Computer Science, Hsinchu, Taiwan, 3Department of Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch, Kaohsiung, Taiwan
14.15-14.25 ORAL 032 [POSTER 214]
Transforming wound assessment and management with artificial intelligence
P. Bishnoi1, Y. Ng1, O. E. Ping2, R. Srivastava2, T. K. Kyar2, D. Y. Tan3, Z. Jingxian3, H. Susainathan3, R. Q. So2
1Skin Research Institute of Singapore, A*STAR, Singapore, Singapore, 2Institute for Infocomm Research, Singapore, Singapore, 3Diagnostics Development Hub, Singapore, Singapore
14.25-14.35 ORAL 033 [POSTER 1572]
HLA I shields tumor lymphocytes from NK-cell-mediated elimination in the skin
Y. Chang1, S. Kimeswenger2, M. Bobrowicz4, S. Pascolo3, W. Hoetzenecker2, E. Guenova1
1Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud, Switzerland, 2Dermatology, Johannes Kepler Universitat Linz, Linz, Austria, 3Dermatology, UniversitatsSpital Zurich, Zurich, Switzerland, 4Immunology, Warszawski Uniwersytet Medyczny, Warszawa, Mazowieckie, Poland
14.35-14.45 ORAL 034 [POSTER 1625]
Novel mechanism of cell proliferation in cutaneous T cell lymphoma
X. Zhang, H. Li, C. Chen, J. Hsiang, S. Nam, W. Hu, X. Wu, D. Horne, J. Shively, S. Rosen
City of Hope, Duarte, California, United States
14.45 PM-14.55 ORAL 035 [POSTER 1545]
Circulating tumor DNA reflects tumor burden and detects early recurrence in patients with Merkel cell carcinoma
T. Akaike1, D. S. Hippe2, N. So3, N. Maloney3, L. Gunnell1, E. Hall1, A. Rodriguez4, A. Aleshin4, P. Nghiem1, L. Zaba3
1University of Washington, Seattle, Washington, United States, 2Fred Hutchinson Cancer Research Center, Seattle, Washington, United States, 3Stanford University School of Medicine, Stanford, California, United States, 4Natera, Inc, Austin, Texas, United States
14.55-15.05 ORAL 036 [POSTER 1556]
CSL324, a G-CSF receptor antagonist, blocks neutrophil migration markers that are upregulated in hidradenitis suppurativa
C. Gamell1, K. Scalzo-Inguanti1, B. Sedgmen1, M. Alhamdoosh1, C. Millar1, L. Johnson1, A. Dyson1, J. Nicolopoulos2, G. Varigos2, M. Ng1, N. Wilson1, J. Field1, J. S. Kern2, L. M. Lindqvist1
1CSL Limited, Parkville, Victoria, Australia, 2The Royal Melbourne Hospital, Parkville, Victoria, Australia
15.05-15.15 ORAL 037 [POSTER 1621]
Spatial mass cytometry-based single cell imaging reveals a disrupted epithelial-immune axis in prurigo nodularis
A. Kambala, J. R. Patel, H. Cornman, K. K. Lee, S. V. Reddy, O. O. Oladipo, W. Ho, S. Kwatra
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
15.15-15.25 ORAL 038 [POSTER 1607]
Multiomic analysis of immune-related adverse events (irAEs) in melanoma patients treated with anti-PD1-based immune checkpoint inhibitors (ICIs)
F. Dimitriou1, P. Cheng1, A. Saltari1, R. Staeger1, A. Tastanova1, M. Levesque1, G. Long3, B. Becher2, R. Dummer1
1Dermatology Department, UniversitatsSpital Zurich, Zurich, Switzerland, 2Immunology Department, Universitat Zurich, Zurich, Switzerland, 3Melanoma Institute Australia, North Sydney, New South Wales, Australia
15.25-15.35 ORAL 039 [POSTER 1598 ]
Comparative proteomic analyses of microdissected nevi and melanoma subtypes reveal functional differences
S. Naimy2, 3, D. Kuczek4, J. B. Solberg1, M. Bzorek2, T. Litman5, A. Mund3, M. B. Lovendorf1, 5, R. Clark6, L. R. Gjerdrum2, 7, M. Mann3, 4, B. Dyring-Andersen1, 3, 5
1Department of Dermatology and Allergy, Herlev-Gentofte University Hospital, Hellerup, Denmark, 2Department of Pathology, Copenhagen University Hospital, Zealand University Hospital, Roskilde, Denmark, 3Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark, 4Max-Planck-Institute of Biochemistry, Munich, Martinsried, Germany, 5Leo Foundation Skin immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, 6Department of Dermatology, Brigham’s and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States, 7Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
15.35-15.45 ORAL 040 [POSTER 1566 ]
Fate induction through asymmetric T cell division is modulated by chimeric antigen receptor co-stimulatory domains
C. Berry1, C. Lee1, A. R. Kelly2, S. Oh1, R. O’Connor2, C. Ellebrecht1
1Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 041 [POSTER 264 ]
Genetic ablation of host p38δ promotes antitumor immunity and reduces tumor growth
A. Kiss1, J. Chen1, F. Cheng1, C. Wei1, N. Adusumilli1, S. Sandhu1, S. Simmens1, E. Sotomayor3, T. Efimova2, 1
1The George Washington University, Washington, District of Columbia, United States, 2Northwestern University, Evanston, Illinois, United States, 3Tampa General Hospital, Tampa, Florida, United States
13.25-13.35 ORAL 042 [POSTER 277]
HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses
C. Olivero1, H. Morgan1, L. Martuscelli2, A. Gibbs1, B. Shorning1, C. Borgogna2, M. De Andrea2, M. Hufbauer3, S. Smola4, H. Pfister3, B. Akgul3, M. Gariglio2, G. Patel1
1European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, United Kingdom, 2Translational Medicine, University of Piemonte Orientale, Novara, Italy, 3Virology, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, 4Virology, Saarland University Medical Center, Homburg, Germany
13.35-13.45 ORAL 043 [POSTER 297]
Expanded genomic landscape of merkel cell carcinoma identifies new drivers
Y. Zhang1, Z. Reinstein1, K. Qiu1, J. Jackson1, M. Nichols2, H. Liu1, K. Tsai2, J. Choi1
1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 2Department of Pathology, Moffitt Cancer Center, Tampa, Florida, United States
13.45-13.55 ORAL 044 [POSTER 267]
Establishment of a new immunocompetent mouse model of merkel cell carcinoma
K. M. Prieto-Sarmiento1, A. de Mingo Pulido1, B. R. Sell1, O. Chavez Chiang1, P. W. Harms2, M. E. Verhaegen2, A. Dlugosz2, T. Patel3, C. Coarfa3, K. Tsai1
1Clinical Science, Moffitt Cancer Center, Tampa, Florida, United States, 2Dermatology, University of Michigan, Ann Arbor, Michigan, United States, 3Baylor College of Medicine, Houston, Texas, United States
13.55-14.05 ORAL 045 [POSTER 311]
Single-cell transcriptomics reveals distinct molecular programs in folliculotropic mycosis fungoides
T. Qin1, A. Billi2, J. Runge2, R. Wasikowski2, Q. Li2, Y. Wang3, M. Sartor2, P. W. Harms2, J. Gudjonsson2, A. Hristov2, L. C. Tsoi2, T. Tejasvi12
1Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States, 2University of Michigan, Ann Arbor, Michigan, United States, 3Peking University, Beijing, China
14.05-14.15 ORAL 046 [POSTER 303 ]
Single-cell RNA sequencing of erythrodermic CTCL compared to atopic dermatitis and unspecific chronic erythroderma defines disease-specific markers
K. Rindler1, S. Chennareddy2, M. Medjimorec1, L. Shaw1, U. Mann1, W. Weninger1, M. Farlik1, C. Jonak1, P. Brunner2
1Department of Dermatology, Medizinische Universitat Wien, Wien, Wien, Austria, 2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
14.15-14.25 ORAL 047 [POSTER 253 ]
PRMT1 inhibition as a novel therapeutic approach in squamous cell carcinoma
R. Boudra1, B. Patenall1, S. King1, S. Xu2, D. Wang2, M. Padilla1, C. Schmults1, S. Barthel1, C. Lian2, M. R. Ramsey1
1Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, United States, 2Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, United States
14.25-14.35 ORAL 048 [POSTER 244 ]
The sphingosine-1-phosphate-cathelicidin axis has a pivotal role in the development of cutaneous squamous cell carcinoma
K. Park1, 2, 3, Y. Kim2, 3, K. Shin1, 4, Y. Bae1, Y. Choi1, A. Nielsen-Scott2, 3, C. Mainzer2, 3, A. Celli2, 3, W. Holleran2, 3, S. Arron2, 3, T. Mauro2, 3, P. Elias2, 3, Y. Uchida1, 2, 3
1Food Science and Nutrition, Hallym University, Chuncheon, Gangwon-do, Korea (the Republic of), 2Dermatology, University of California San Francisco, San Francisco, California, United States, 3Northern California Institute for Research and Education, San Francisco, California, United States, 4LaSS Inc., Chunche, Korea (the Republic of)
14.35-14.45 ORAL 049 [POSTER 258 ]
Ire1α nmsc mutations enhance keratinocyte uv response and survival through rac1 activation
S. Mogre, J. Son, A. Glick
The Pennsylvania State University, University Park, Pennsylvania, United States
14.45-14.55 ORAL 050 [POSTER 250 ]
A specific neurotrophin network characterizes cSCC subpopulations and correlates with their behavior by patient-derived spheroids and zebrafish avatar
M. Quadri1, L. Reggiani Bonetti2, R. Panini2, N. Tiso3, R. Lotti1, C. Pincelli1, A. Marconi1, E. Palazzo1
1CHIMOMO, Unimore, Modena, Italy, 2Dept of Pathology, Unimore, Modena, Italy, 3Dept of Biology, UniPD, Padua, Italy
14.5-15.05 ORAL 051 [POSTER 275 ]
Spatial transcriptomics of early invasive melanomas reveals molecular determinants of patient survival
C. Zhou1, S. X. Tan1, Y. Kao1, M. Claeson5, S. Brown1, D. Lambie3, D. Whiteman2, H. Soyer1, M. Stark1, Q. Nguyen4, K. Khosrotehrani1
1The University of Queensland Frazer Institute, Brisbane, Queensland, Australia, 2QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, 3Pathology Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia, 4The University of Queensland Institute for Molecular Bioscience, Saint Lucia, Queensland, Australia, 5Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
15.05-15.15 ORAL 052 [POSTER 289 ]
Crosstalk between MET-dependent receptor tyrosine kinase signaling and oncogenic Gαq mutations in melanoma
B. Andreas1, M. Mengoni1, S. Seedarala1, S. Bonifatius1, E. Kostenis2, T. Tüting1, E. Gaffal1
1Dermatology, University Hospital Magdeburg, Magdeburg, Germany, 2University of Bonn, Bonn, Germany
15.15-15.25 ORAL 053 [POSTER 233 ]
Epigenetic age dysregulation is associated with clinical features of cutaneous melanoma and melanocytic nevi
R. Jeremian1, 2, J. R. Georgakopoulos3, 4, J. Yeung4, 3, I. Litvinov2, 1
1McGill University Faculty of Medicine and Health Sciences, Montreal, Quebec, Canada, 2McGill University Health Centre, Montreal, Quebec, Canada, 3University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada, 4Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
15.25-15.35 ORAL 054 [POSTER 305 ]
Matrix metalloproteinase-1 expression in fibroblasts accelerates dermal aging and promotes tumor development in mouse skin
G. J. Fisher1, W. Xia1, T. He1, G. Bou-Gharios2, J. J. Voorhees1, A. Dlugosz1, T. Quan1
1Dermatology, University of Michigan, Ann Arbor, Michigan, United States, 2Matrix Biology, University of Liverpool Faculty of Health and Life Sciences, Liverpool, United Kingdom
15.35-15.45 ORAL 055 [POSTER 316 ]
EPHB2 germline mutation in patients with high frequency basal cell carcinomas and prostate carcinoma
A. Chiang1, G. Swaminathan1, M. Harris1, V. Hua1, W. Chan1, J. Ramos1, K. Yekrang1, H. Do1, I. Bailey1, K. E. Rieger1, 2, C. Curtis3, 4, J. Y. Tang1, A. Oro1, K. Sarin1
1Dermatology, Stanford University School of Medicine, Stanford, California, United States, 2Dermatopathology, Stanford University School of Medicine, Stanford, California, United States, 3Medicine (Oncology), Stanford University School of Medicine, Stanford, California, United States, 4Genetics, Stanford University School of Medicine, Stanford, California, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 056 [POSTER 448 ]
A framework to study the epidemiological and molecular basis of psoriasis severity, with application in UK Biobank and BSTOP
J. Saklatvala1, R. Ramessur1, M. Simpson1, S. M. Langan3, S. Brown4, L. Paternoster2, N. Dand1, C. Smith1
1King’s College London, London, United Kingdom, 2University of Bristol, Bristol, United Kingdom, 3London School of Hygiene & Tropical Medicine, London, United Kingdom, 4University of Edinburgh, Edinburgh, United Kingdom
13.25-13.35 ORAL 057 [POSTER 446 ]
The risk of lymphoproliferative disorders and skin cancers in patients with psoriasis and inflammatory bowel disease administered biologics
J. Jung, E. Choi, G. Kim, S. Chang, M. Lee, C. Won, W. Lee
Dermatology, Asan Medical Center, Songpa-gu, Seoul, Korea (the Republic of)
13.35-13.45 ORAL 058 [POSTER 407 ]
A population-based cohort study of sodium consumption and psoriasis
A. Chattopadhyay, B. Chiang, Y. Halezeroglu, K. Abuabara
University of California San Francisco, San Francisco, California, United States
13.45-13.55 ORAL 059 [POSTER 394 ]
Differential associations of psoriasis subtypes with autoimmune disorders in United States children and adults: A cross-sectional study
Z. Ren1, J. Silverberg2
1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 2Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States
13.55-14.05 ORAL 060 [POSTER 552 ]
Transitions in blood immune profile in atopic dermatitis from infancy to adulthood
E. Del Duca1, Y. Renert-Yuval2, A. Pavel1, D. Mikhaylov1, R. Lefferdink1, M. Fang1, A. Sheth3, P. Facheris1, J. Wu1, Y. Estrada1, S. Rangel3, J. Krueger2, A. Paller3, E. Guttman-Yassky1
1Icahn School of Medicine at Mount Sinai, New York, New York, United States, 2Dermatology, The Rockefeller University, New York, New York, United States, 3Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
14.05-14.15 ORAL 061 [POSTER 383 ]
Non-invasively collected RNA in sebum reflects the characteristics and severity of atopic dermatitis.
A. Tanaka1, T. Nakahara2, K. Masuda3, N. Takada4, T. Kuwano4, T. Inoue4, S. Hoashi5, Y. Kawasaki5, H. Saeki6
1Department of Dermatology, Hiroshima Daigaku, Hiroshima, Hiroshima, Japan, 2Department of Dermatology, Kyushu Daigaku, Fukuoka, Fukuoka, Japan, 3Department of Dermatology, Kyoto Furitsu Ika Daigaku, Kyoto, Kyoto, Japan, 4Biological Science Laboratory, Kao Kabushiki Kaisha, Chuo, Tokyo, Japan, 5Diagnostics Department, Maruho Kabushiki Kaisha, Osaka, Osaka, Japan, 6Department of Dermatology, Nihon Ika Daigaku, Bunkyo, Tokyo, Japan
14.15-14.25 ORAL 062 [POSTER 540 ]
A longitudinal cohort study of atopic dermatitis and epigenetic age acceleration across childhood
M. Ye1, P. Collender2, S. M. Langan3, A. Cardenas4, K. Abuabara1, 2
1UCSF, San Francisco, California, United States, 2UC Berkeley, Berkeley, California, United States, 3LSHTM, London, United Kingdom, 4Stanford University, Stanford, California, United States
14.25-14.35 ORAL 063 [POSTER 558 ]
Higher hemoglobin A1C is associated with greater disease severity in hidradenitis suppurativa
N. Foolad1, W. Liu1, 2, J. T. Kwock1, T. Jaleel1
1Dermatology, Duke University School of Medicine, Durham, North Carolina, United States, 2Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, United States
14.35-14.45 ORAL 064 [POSTER 489 ]
Long-term oral antibiotics for acne and antibiotic treatment failure
K. Bhate1, R. Mathur2, S. M. Langan1
1London School of Hygiene & Tropical Medicine, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom
14.45-14.55 ORAL 065 [POSTER 470 ]
Regulatory T cells act either by expansion at the acute phase or by steep contraction at the resolution phase in severe drug eruptions
Y. Mizukawa, R. Takahashi, T. Shiohara
Kyorin Daigaku, Mitaka, Tokyo, Japan
14.55-15.05 ORAL 066 [POSTER 562 ]
Merkel polyomavirus antibody testing for detecting recurrent Merkel cell carcinoma: A prospective, real-world outcomes study
L. Gunnell1, T. Akaike1, K. Lachance1, D. S. Hippe2, K. Cahill1, C. Doolittle-Amieva2, 1, L. Zawacki1, S. Park1, 2, P. Nghiem1, 2
1University of Washington Department of Medicine, Seattle, Washington, United States, 2Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
15.05-15.15 ORAL 067 [POSTER 385 ]
Skin cancers in patients with actinic keratoses
C. Mohr1, Y. Li1, L. Navsaria1, C. Hinkston1, D. Margolis2, M. Wehner1
1Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States, 2University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
15.15-15.25 ORAL 068 [POSTER 450 ]
The impact of mental health comorbidities on patient satisfaction: A population study among U.S. adults with skin cancer
C. Read2, 1, 3, J. F. Apperley2, S. P. Hettiaratchy2, A. Armstrong1
1Dermatology, University of Southern California, Los Angeles, California, United States, 2Medicine, Imperial College London, London, United Kingdom, 3Dermatology, University of Washington, Seattle, Washington, United States
15.25-15.35 ORAL 069 [POSTER 541 ]
Gene set enrichment analysis identifies biological networks associated with skin aging in a large Japanese population: Data from the Nagahama cohort
J. Latreille3, G. Thorn1, 2, R. Jdid3, G. Gendronneau3, Y. Tabara4, Y. Harada5, S. Forestier3, C. Chelala1, 2, F. Matsuda4
1Bioinformatics Unit, Barts Cancer Institute, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom, 3IRD, Chanel SAS, PANTIN, Île-de-France, France, 4Center for Genomic Medicine, Kyoto Daigaku Igaku Kenkyuka Fuzoku Genome Igaku Center, Kyoto, Japan, 5Research and Technology Development Laboratory, Chanel Kabushiki Kaisha Funabashi Corporate Operations Center, Funabashi, Chiba, Japan
15.35-15.45 ORAL 070 [POSTER 421 ]
Genotype-phenotype correlation analysis in Japanese patients with pachydermoperiostosis
R. Tanaka1, H. Niizeki1, T. Nomura2, A. Seki3, S. Narumi4, K. Nakabayashi5, K. Yoshida1
1Dermatology, National Center for Child Health and Development, Tokyo, Japan, 2Dermatology, Kyoto University, Kyoto, Japan, 3Orthopaedic Surgery, National Center for Child Health and Development, Tokyo, Japan, 4Molecular Endocrinology, National Center for Child Health and Development, Tokyo, Setagaya-ku, Japan, 5Maternal-Fetal Biology, National Center for Child Health and Development, Tokyo, Japan
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 071 [POSTER 806 ]
Results from VIITAL: A phase 3, randomized, intrapatient-controlled trial of an investigational collagen type VII gene–corrected autologous cell therapy, EB-101, for the treatment of recessive dystrophic epidermolysis bullosa (RDEB)
J. Y. Tang2, M. P. Marinkovich2, 3, K. Wiss4, D. McCarthy5, A. Truesdale1, A. S. Chiou2, J. K. McIntyre4, A. Moore1, I. Grachev1
1Abeona Therapeutics Inc, Cleveland, Ohio, United States, 2Stanford University School of Medicine, Stanford, California, United States, 3VA Palo Alto Health Care System, Palo Alto, California, United States, 4University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 5Abeona Therapeutics Inc, Cleveland, Ohio, United States
13.25-13.35 ORAL 072 [POSTER 853 ]
HMCN1 variants aggravate epidermolysis bullosa phenotype
S. Bergson1, 2, O. Sarig1, A. Nitzan2, S. Hainzl3, T. Kocher3, M. Giladi1, 2, J. Illmer3, J. Mohamad1, 2, E. Geller1, 2, K. Malovitski1, 2, Y. Feller1, 2, N. Eretz Kdosha1, R. Zauner3, J. Pinon Hofbauer3, R. Shalom-Feuerstein4, V. Wally3, U. Koller3, R. Zaidel-Bar2, L. Samuelov1, 2, E. Sprecher1, 2
1Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel Aviv University, Tel Aviv, Israel, 3Paracelsus Medical University, EB House Austria, Salzburg, Austria, 4Technion Israel Institute of Technology, Haifa, Israel
13.35 PM-13.45 ORAL 073 [POSTER 849 ]
Twin prime editing for restoring type VII collagen expression in primary recessive dystrophic epidermolysis patient cells
M. Osborn, B. Steinbeck, A. N. McElroy, J. Tolar
Pediatrics, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States
13.45-13.55 ORAL 074 [POSTER 884 ]
Reproducible correction of COL7A1 nonsense variants with ABE8e adenine base editor
J. K. Jackow1, A. Sheriff1, I. Guri1, I. Brooks1, M. Dimitrievska1, G. Newby2, D. Liu2, L. Laczmanski3, J. A. McGrath1
1St John’s Institute of Dermatology, King’s College London, London, United Kingdom, 2Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States, 3Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
13.55-14.05 ORAL 075 [POSTER 875 ]
ELX-02 suppress premature stop mutations and restores type VII collagen and laminin 332 function in RDEB and JEB
Y. Hou1, X. Tang1, L. Bainvoll1, S. Aghamohammadzadeh2, M. Chen1
1Dermatology, University of Southern California, Los Angeles, California, United States, 2Eloxx Pharmaceuticals, Watertown, Massachusetts, United States
14.05-14.15 ORAL 076 [POSTER 861 ]
CTSZ pathogenic variants affect EGFR expression and cause autosomal dominant palmoplantar keratoderma
K. Malovitski1, 2, O. Sarig1, Y. Feller1, 2, S. Bergson1, 2, S. Assaf1, 2, J. Mohamad1, 2, M. Pavlovsky1, M. Giladi2, 3, E. Sprecher1, 2
1Division of Dermatology, Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel, 3Department of Internal Medicine D, Tel Aviv Medical Center, Tel Aviv, Israel
14.15-14.25 ORAL 077 [POSTER 807 ]
Alternative mRNA splicing regulates epidermal differentiation
S. Takashima1, 3, W. Sun2, A. Otten1, P. Cai2, J. Bui1, M. Mai1, O. Amarbayar1, B. Cheng1, E. Tong1, Z. Li2, K. Qu2, B. Sun1
1Department of Dermatology, University of California San Diego, La Jolla, California, United States, 2Division of Molecular Medicine, University of Science and Technology of China, Hefei, Anhui, China, 3Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
14.25-14.35 ORAL 078 [POSTER 812 ]
Regulation of keratinocyte proliferation and differentiation by nucleoporins through nucleocytoplasmic trafficking and direct chromatin binding
X. Bao, A. Neely, Y. Zhang, H. Zhang
Northwestern University, Evanston, Illinois, United States
14.35 PM-14.45 ORAL 079 [POSTER 864 ]
Homologous recombination is prevalent in normal keratinocytes in vivo in mice
G. Egawa, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
14.45-14.55 ORAL 080 [POSTER 840 ]
Excess klhl24 impairs skin wound healing by degradation of vimentin
Y. Liu1, J. Cui2, J. Zhang2, Z. Chen1, Z. Song1, D. Bao1, R. Xiang1, D. Li1, Y. Yang1
1Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China, 2Peking University First Hospital, Beijing, China
14.55-15.05 ORAL 081 [POSTER 860 ]
Fragile WWOX gene maintains genome integrity in fibroblasts
H. Cheng2, Y. Chou3, C. Hsu2, L. Hsu1
1Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University College of Medicine, Tainan, Taiwan, 2Department of Dermatology, National Cheng Kung University College of Medicine, Tainan, Taiwan, 3Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan
15.05-15.15 ORAL 082 [POSTER 882 ]
Enhancer RNA (eRNA) profiling to understand transcription regulation in keratinocytes
M. T. Patrick, M. Sarkar, Z. Zhang, H. Zhang, J. T. Elder, J. Gudjonsson, L. C. Tsoi
University of Michigan, Ann Arbor, Michigan, United States
15.15-15.25 ORAL 083 [POSTER 877 ]
Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes
M. Lee1, 2, M. Ben Hammouda1, W. Miao1, Y. J. Jin1, Y. Huang1, H. Sun1, V. Markovtsov3, J. Y. Zhang1
1Dermatology, Duke University School of Medicine, Durham, North Carolina, United States, 2Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States, 3Rigel Pharmaceuticals Inc, South San Francisco, California, United States
15.25-15.35 ORAL 084 [POSTER 808 ]
Seizures in Sturge-Weber syndrome are associated with disrupted calcium metabolism
D. Zecchin1, 2, N. Knoepfel1, 2, 3, A. K. Gluck4, M. Stevenson4, H. Richardson3, S. Polubothu2, 3, A. Inoue5, K. Lines4, A. Chesover3, T. Jacques3, 2, F. Hannan4, U. Loebel3, R. Semple6, R. V. Thakker4, V. A. Kinsler1, 2, 3
1The Francis Crick Institute, London, London, United Kingdom, 2University College London, London, London, United Kingdom, 3Great Ormond Street Hospital for Children NHS Foundation Trust, London, London, United Kingdom, 4University of Oxford, Oxford, Oxfordshire, United Kingdom, 5Tohoku Daigaku, Sendai, Miyagi, Japan, 6University of Edinburgh, Edinburgh, United Kingdom
15.35-15.45 ORAL 085 [POSTER 841 ]
A vitiligo-associated SNP (rs706779) controls IL15RA isoforms and T cell activation in epidermal keratinocytes
K. Okamura1, 2, S. Shan3, Q. Tang1, 4, P. Vangala3, X. Fan1, C. Salomão Lopes3, Y. Cao3, W. Ko3, T. Suzuki2, A. Khvorova4, M. Garber3, J. E. Harris1
1Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 2Department of Dermatology, Faculty of Medicine, Yamagata University, Yamagata, Japan, 3Department of Bioinformatics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States, 4RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States
Concurrent talks are 8 minutes plus 2 minutes discussion
13.15-13.25 ORAL 086 [POSTER 1512 ]
Combined transcriptome and epigenome profiling reveal regulators of dermal fibroblast state switch
T. Kirk, A. Ahmed, J. Connelly, E. Rognoni
Queen Mary University of London, London, United Kingdom
13.25-13.35 ORAL 087 [POSTER 1448 ]
Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration
A. S. Oak, Y. Zheng, A. Nace, R. Yang, A. Ray, G. Cotsarelis
Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
13.35-13.45 ORAL 088 [POSTER 1478 ]
TEM1/endosialin/CD248 promotes pathologic scarring by augmenting TGF-β activity through its receptor stability in dermal fibroblasts
Y. Hong1, 2, 4, Y. Lin1, 2, Y. Chang1, Y. Huang1, J. A. McGrath1, 6, H. Wu2, 3, 4, C. Hsu1, 2, 5
1Department of Dermatology, National Cheng Kung University, Tainan, Taiwan, 2International Center for Wound Repair and Regeneration (iWRR), National Cheng Kung University, Tainan, Taiwan, 3Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan, 4The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan, 5Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, 6St John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, London, London, United Kingdom
13.45-13.55 ORAL 089 [POSTER 1475 ]
Single cell RNA-seq reveals cell-type specific circadian regulations in the mouse dermis
J. Duan1, M. Ngo1, S. Karri2, J. Lowengrub1, B. Shahbaba1, B. Andersen2
1Center for Complex Biological Systems, University of California Irvine, Irvine, California, United States, 2Department of Biological Chemistry, University of California Irvine, Irvine, California, United States
13.55-14.05 ORAL 090 [POSTER 1480 ]
CXCR4 expression by regulatory T cells promotes cutaneous tissue regeneration
J. Cohen, M. Rosenblum
Dermatology, University of California San Francisco, San Francisco, California, United States
14.05-14.15 ORAL 091 [POSTER 1518 ]
Identification of gene products from staphylococcus aureus that inhibit keratinocyte migration and wound repair
M. D. Bagood1, A. Horswill2, R. L. Gallo1
1Dermatology, University of California San Diego, La Jolla, California, United States, 2Immunology & Microbiology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States
14.15-14.25 ORAL 092 [POSTER 1493 ]
Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway
D. C. Wan, M. Griffin, C. E. Berry, M. T. Longaker
Surgery, Stanford University School of Medicine, Stanford, California, United States
14.25-14.35 ORAL 093 [POSTER 1520 ]
Tissue mechanics driven symmetry breaking and cellular reprogramming during regenerative wound healing
H. Harn1, C. Huang1, 2, 3, C. Chen1, 4, A. Sarkar5, B. Van Handel5, T. E. Woolley6, D. Evseenko5, C. Chuong1
1Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States, 2Ostraw School of Dentistry, University of Southern California, Los Angeles, California, United States, 3Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 4The IEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, 5Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United States, 6Cardiff University School of Mathematics, Cardiff, United Kingdom
14.35-14.45 ORAL 094 [POSTER 1541 ]
Co-transcription factors YAP and TAZ regulate dermal extracellular matrix homeostasis and scar formation in mouse skin
A. Ermilov, Z. Qin, A. Kim, T. Quan, J. J. Voorhees, G. J. Fisher
Dermatology, University of Michigan, Ann Arbor, Michigan, United States
14.45-14.55 ORAL 095 [POSTER 1453 ]
LncRNA SNHG26 facilitates inflammatory to proliferative state transition of keratinocyte progenitors during wound healing
D. Li1, 2, Z. Liu2, L. Zhang2, X. Bian2, J. Wu3, L. Li1, L. Pan1, Y. Xiao1, J. Wang1, X. Zhang1, W. Wang4, M. Toma2, M. Piipponen2, L. Luo2, P. Sommar2, N. Xu Landén2
1Affiliated Hospital for Skin Diseases of Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China, 2Karolinska Institutet, Stockholm, Stockholm, Sweden, 3Wenzhou Medical University, Wenzhou, Zhejiang, China, 4East China Normal University, Shanghai, Shanghai, China
14.55-15.05 ORAL 096 [POSTER 1506 ]
Multimodal transcriptomics highlight fibroblast heterogeneity and pathological signaling networks in keloid
Y. Liu1, 2, C. F. Guerrero-Juarez2, Q. Nie2, J. Li1, M. Plikus2
1Xiangya Hospital Central South University, Changsha, Hunan, China, 2University of California Irvine School of Biological Sciences, Irvine, California, United States
15.05-15.15 ORAL 097 [POSTER 1519 ]
Topical type VII collagen increased elastic fiber formation, accelerated wound closure and reduced scarring of diabetic pigskin wounds.
D. Woodley, Y. Hou, X. Tang, C. Tan, K. Zhang, L. Bainvoll, W. Li, M. Chen
Dermatology, University of Southern California, Los Angeles, California, United States
15.15-15.25 ORAL 098 [POSTER 1500 ]
FoxO3a-regulating mitochondrial dynamics affects wound healing through regulating fibroblast migration
S. Goto1, M. Moriyama2, M. Wakatake3, Y. Miyake1, H. Moriyama1
1Kinki Daigaku, Higashiosaka, Osaka, Japan, 2Kinki Daigaku, Higashiosaka, Osaka, Japan, 3Kinki Daigaku, Higashiosaka, Osaka, Japan
15.25-15.35 ORAL 099 [POSTER 1507 ]
MCSP+ pericytes on the dermal capillary loop as a potential source for epidermal stem/ progenitor cells and their reduction with age.
M. Sawane, T. Tsutsui, M. Komata, R. Kami, H. Aoki, K. Kajiya
MIRAI Technology Institute, Shiseido Co., Ltd, Yokohama, Japan
15.35-15.45 ORAL 100 [POSTER 1455 ]
Identification and characterization of specific subsets in systemic sclerosis fibroblast cultures
A. S. Rosendahl1, K. Schönborn1, N. Kleinenkuhnen2, T. Baar2, A. Tresch2, B. Eckes1, P. Moinzadeh3, T. Krieg1
1Translational Matrix Bioogy, Faculty of Medicine, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, 2Institute of Medical Statistics and Computational Biology, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany, 3Department of Dermatology, Universitat zu Koln, Koln, Nordrhein-Westfalen, Germany
