Title: Non-coding RNAs, RNA structure, the human regulome, and cancer immunotherapy
Date: Friday 12 May 2023
Time: 9.45-10.15 JPN
Howard Y. Chang M.D., Ph.D. is the Virginia and D.K. Ludwig Professor of Cancer Research and Director of the Center for Personal Dynamic Regulomes at Stanford University. He is a Howard Hughes Medical Institute Investigator; he is also Professor of Dermatology and of Genetics at Stanford University School of Medicine. Chang earned a Ph.D. in Biology from MIT, M.D. from Harvard Medical School, and completed Dermatology residency and postdoctoral training at Stanford University. His research addresses how large sets of genes are turned on or off together, which is important in normal development, cancer, and aging. Chang discovered a new class of genes, termed long noncoding RNAs, can control gene activity throughout the genome, illuminating a new layer of biological regulation. He invented ATAC-seq and other new methods for defining DNA regulatory elements genome-wide and in single cells. The long term goal of his research is to decipher the regulatory information in the genome to benefit human health.
Dr. Chang is a Member of the US National Academy of Sciences, National Academy of Medicine, and American Academy for the Arts and Sciences. Dr. Chang’s honors include the NAS Award for Molecular Biology, Outstanding Investigator Award of the National Cancer Institute, Paul Marks Prize for Cancer Research, Judson Daland Prize of the American Philosophical Society, and the Vilcek Prize for Creative Promise. His work was honored by the journal Cell as a Landmark paper over the last 40 years and by Science as “Insight of the decade”.